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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4613-4618

Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl) pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease

(7) Sunose, Mihiro a Bell, Kathryn a Ellard, Katie a Bergamini, Giovanna b Neubauer, Gitte b Werner, Thilo b Ramsden, Nigel a

a Cellzome Ltd (United Kingdom)

b GLAXOSMITHKLINE (United Kingdom)

Author keywords

Collagen induced arthritis; Inflammation; PI3K ; Rheumatoid arthritis; Triazolopyridine

Indexed keywords

5 (2 AMINO[1,2,4]TRIAZOLO[1,5 A]PYRIDIN 7 YL) N (TERT BUTYL)PYRIDINE 3 SULFONAMIDE; COLLAGEN; CZC 24785; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG TARGETING; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; REVIEW;

EID: 84863463782 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.05.090 Document Type: Article

Times cited : (24)

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