Massive monoclonal expansion of CD4 T-cells specific for a Mycobacterium tuberculosis ESAT-6 peptide

European Respiratory Journal

Volumn 40, Issue 1, 2012, Pages 152-160

  Hodapp, Tobias ^a   Sester, Urban ^a   Mack, Ulrich ^a,g   Singh, Mahavir ^b,c   Meier, Thomas ^d,e,f   Wiech, Elisabeth ^h   Fisch, Paul ^h   Ehl, Stephan ^f   Sester, Martina ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c LIONEX DIAGNOSTICS AND THERAPEUTICS GMBH   (Germany)

^d Laboratory Prof G Enders and Partners   (Germany)

^e Institute of Virology   (Germany)

^f UNIVERSITY OF FREIBURG   (Germany)

^g LOVISENBERG DIAKONALE HOSPITAL   (Norway)

^h NONE

Author keywords

Cd4 T cells; Early secretory antigenic target 6; Lymphocytes; Monoclonal; Monoclonal gammopathy of undetermined significance; Mycobacterium tuberculosis

Indexed keywords

EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

AGED; ARTICLE; CASE REPORT; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL FEATURE; ENZYME LINKED IMMUNOSPOT ASSAY; EPITOPE MAPPING; FLOW CYTOMETRY; HEMOPTYSIS; HUMAN; HUMAN CELL; LUNG LAVAGE; MALE; MYCOBACTERIUM TUBERCULOSIS; OUTCOME ASSESSMENT; PHENOTYPE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; TUBERCULOSIS;

EID: 84863461512     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00175611     Document Type: Article

References (34)

1. Mack U, Migliori GB, Sester M, et al. LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. Eur Respir J 2009; 33: 956-973.
2. Sester U, Fousse M, Dirks J, et al. Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states. PLoS One 2011;6: e17813.
3. Sester U, Junker H, Hodapp T, et al. Improved efficiency in detecting cellular immunity towards M. tuberculosis in patients receiving immunosuppressive drug therapy. Nephrol Dial Transplant 2006; 21: 3258-3268. (Pubitemid 44567103)
4. Lalvani A, Nagvenkar P, Udwadia Z, et al. Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians. J Infect Dis 2001; 183: 469-477. (Pubitemid 32105605)
5. Ulrichs T, Munk ME, Mollenkopf H, et al. Differential T cell responses to Mycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors. Eur J Immunol 1998; 28: 3949-3958. (Pubitemid 28558625)
6. Sester M, Sester U, Gärtner B, et al. Sustained high frequencies of specific CD4 T cells restricted to a single persistent virus. J Virol 2002; 76: 3748-3755. (Pubitemid 34250539)
7. Sester U, Wilkens H, van Bentum K, et al. Impaired detection of Mycobacterium tuberculosis immunity in patients using high levels of immunosuppressive drugs. Eur Respir J 2009; 34: 702-710.
8. Sester U, Presser D, Dirks J, et al. PD-1 expression and IL-2 loss of cytomegalovirus-specific T cells correlates with viremia and reversible functional anergy. Am J Transplant 2008; 8: 1486-1497. (Pubitemid 351989503)
9. Pannetier C, Levraud JP, Lim A, et al. The immunoscope approach for the analysis of T cell repertoires. In: Oksenberg JR, ed. The Antigen T Cell Receptor: Selected Protocols and Applications. Chapman and Hall, London, 1998; pp. 287-325.
10. Rammensee H, Bachmann J, Emmerich NP, et al. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 1999; 50: 213-219. (Pubitemid 30099526)
11. Lefranc MP, Giudicelli V, Ginestoux C, et al. IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res 2009; 37: D1006-D1012.
12. Cosmi L, Maggi L, Santarlasci V, et al. Detection by flow cytometry of ESAT-6- and PPD-specific circulating CD4+ T lymphocytes as a diagnostic tool for tuberculosis. Int Arch Allergy Immunol 2007; 143:1-9. (Pubitemid 46625231)
13. Hughes AJ, Hutchinson P, Gooding T, et al. Diagnosis of Mycobacterium tuberculosis infection using ESAT-6 and intracellular cytokine cytometry. Clin Exp Immunol 2005; 142: 132-139. (Pubitemid 41361016)
14. Harari A, Rozot V, Enders FB, et al. Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease. NatMed 2011; 17: 372-376.
15. Ewer K, Millington KA, Deeks JJ, et al. Dynamic antigen-specific T-cell responses after point-source exposure to Mycobacterium tuberculosis. Am J Respir Crit Care Med 2006; 174: 831-839. (Pubitemid 44511666)
16. Borgia P, Cambieri A, Chini F, et al. Suspected transmission of tuberculosis in a maternity ward from a smear-positive nurse: preliminary results of clinical evaluations and testing of neonates potentially exposed, Rome, Italy, 1 January to 28 July 2011. Euro Surveill 2011; 16: pii19984.
17. McMurray DN, Echeverri A. Cell-mediated immunity in anergic patients with pulmonary tuberculosis. Am Rev Respir Dis 1978; 118:827-834. (Pubitemid 9066035)
18. Magnani ZI, Confetti C, Besozzi G, et al. Circulating, Mycobacterium tuberculosis-specific lymphocytes from PPD skin test-negative patients with tuberculosis do not secrete interferon-gamma (IFN-gamma) and lack the cutaneous lymphocyte antigen skin-selective homing receptor. Clin Exp Immunol 2000; 119: 99-106. (Pubitemid 30064597)
19. Vukmanovic-Stejic M, Rustin MH, Nikolich-Zugich J, et al. Immune responses in the skin in old age. Curr Opin Immunol 2011; 23: 525-531.
20. Agius E, Lacy KE, Vukmanovic-Stejic M, et al. Decreased TNFalpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J Exp Med 2009; 206: 1929-1940.
21. Reed JR, Vukmanovic-Stejic M, Fletcher JM, et al. Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. J Exp Med 2004; 199: 1433-1443. (Pubitemid 38685734)
22. Tully G, Kortsik C, Hohn H, et al. Highly focused T cell responses in latent human pulmonary Mycobacterium tuberculosis infection. J Immunol 2005; 174: 2174-2184. (Pubitemid 40223962)
23. Wedemeyer H, Mizukoshi E, Davis AR, et al. Cross-reactivity between hepatitis C virus and influenza A virus determinant-specific cytotoxic T cells. J Virol 2001; 75: 11392-11400. (Pubitemid 33063230)
24. Urbani S, Amadei B, Fisicaro P, et al. Heterologous T cell immunity in severe hepatitis C virus infection. J Exp Med 2005; 201: 675-680. (Pubitemid 40395112)
25. Clute SC, Watkin LB, Cornberg M, et al. Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis. J Clin Invest 2005; 115: 3602-3612. (Pubitemid 43121849)
26. Welsh RM, Che JW, Brehm MA, et al. Heterologous immunity between viruses. Immunol Rev 2010; 235: 244-266.
27. Shin SH, Kim HS, Jung SH, et al. Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis. Exp Mol Med 2008; 40: 229-236.
28. Kim S, You S, Hwang D. Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping. Nat Rev Cancer 2011; 11:708-718.
29. Amyes E, Hatton C, Montamat-Sicotte D, et al. Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. J Exp Med 2003; 198: 903-911. (Pubitemid 37152927)
30. Meyerson HJ. A practical approach to the flow cytometric detection and diagnosis of T-cell lymphoproliferative disorders. Lab Hematol 2010; 16: 32-52.
31. Kyle RA, Rajkumar SV. Monoclonal gammopathy of undetermined significance. Br J Haematol 2006; 134: 573-589. (Pubitemid 44255500)
32. Posnett DN, Sinha R, Kabak S, et al. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J Exp Med 1994; 179: 609-618.
33. Grunewald J, Jeddi-Tehrani M, Dersimonian H, et al. A persistent T cell expansion in the peripheral blood of a normal adult male: a new clinical entity? Clin Exp Immunol 1992; 89: 279-284.
34. Gniadecki R, Lukowsky A. Monoclonal T-cell dyscrasia of undetermined significance associated with recalcitrant erythroderma. Arch Dermatol 2005; 141: 361-367. (Pubitemid 40365452)