A novel convergent method for the synthesis of α-acyl-γ- hydroxylactams and its application in the total synthesis of PI-090 and 091

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4765-4768

  Uchiro, Hiromi ^a   Shionozaki, Nobuhiro ^a   Kobayakawa, Yu ^a   Nakagawa, Hiroko ^a   Makino, Kimiko ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Acyl hydroxylactam; PI 090; PI 091; Platelet aggregation inhibitor; Total synthesis

Indexed keywords

ANTITHROMBOCYTIC AGENT; LACTAM DERIVATIVE; PI 090; PI 091; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; THROMBOCYTE AGGREGATION INHIBITION;

ACYLATION; HYDROXYLATION; LACTAMS; MOLECULAR STRUCTURE;

EID: 84863461400     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.065     Document Type: Article

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