Cyclosporin A induces apoptosis in H9c2 cardiomyoblast cells through calcium-sensing receptor-mediated activation of the ERK MAPK and p38 MAPK pathways

Molecular and Cellular Biochemistry

Volumn 367, Issue 1-2, 2012, Pages 227-236

  Chi, Jinyu ^a   Zhu, Yejing ^a   Fu, Yu ^a   Liu, Yue ^a   Zhang, Xiaohui ^a   Han, Lei ^a   Yin, Xinhua ^a   Zhao, Dechao ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Calcium sensing receptor; Cyclosporine A; ERK MAPK; p38 MAPK

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIUM SENSING RECEPTOR; CASPASE 3; CYCLOSPORIN A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NPS 2390; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLAST CELL; CONCENTRATION RESPONSE; DRUG ANTAGONISM; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME REGULATION; HEART MUSCLE CELL; NONHUMAN; RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE; CYCLOSPORINE; ENZYME ACTIVATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MYOBLASTS, CARDIAC; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECEPTORS, CALCIUM-SENSING; UP-REGULATION;

EID: 84863457103     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1336-5     Document Type: Article

References (36)

1. Kahan BD (1992) Immunosuppressive therapy. Curr Opin Immunol 4:553-560
2. Borel JF, Baumann G, Chapman I, Donatsch P, Fahr A, Mueller EA, Vigouret JM (1996) In vivo pharmacological effects of ciclosporin and some analogues. Adv Pharmacol 35:115-246
3. Krejci K, Tichy T, Bachleda P, Zadrazil J (2010) Calcineurin inhibitor-induced renal allograft nephrotoxicity. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 154:297-306
4. Warren RB, Griffiths CE (2008) Systemic therapies for psoriasis: methotrexate, retinoids, and cyclosporine. Clin Dermatol 26: 438-447
5. Rezzani R (2006) Exploring cyclosporine A-side effects and the protective role-played by antioxidants: the morphological and immunohistochemical studies. Histol Histopathol 21:301-316
6. Kockx M, Jessup W, Kritharides L (2010) Cyclosporin A and atherosclerosis: cellular pathways in atherogenesis. Pharmacol Ther 128:106-118
7. Schreiner KD, Kelemen K, Zehelein J, Becker R, Senges JC, Bauer A, Voss F, Kraft P, Katus HA, Schoels W (2004) Biventricular hypertrophy in dogs with chronic AV block: effects of cyclosporin A on morphology and electrophysiology. Am J Physiol Heart Circ Physiol 287:H2891-H2898 (Pubitemid 39557165)
8. Sandrine Bèsa, David Vandrouxa, Cindy Tissiera, Lisa Devillarda, Amandine Brochota, Etienne Tatoua, Laurence Duvillardb, Luc Rochettea, Pierre Athias (2005) Direct, pleiotropic protective effect of cyclosporin A against simulated ischemia-induced injury in isolated cardiomyocytes. Eur J Pharmacol 511:109-120
9. Sharov VG, Todor A, Khanal S, Imai M, Sabbah HN (2007) Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure. J Mol Cell Cardiol 42:150-158 (Pubitemid 44958623)
10. Rezzani R, Rodella L, Dessy C, Daneau G, Bianchi R, Feron O (2003) Changes in Hsp90 expression determine the effects of cyclosporine A on the NO pathway in rat myocardium. FEBS Lett 552:125-129 (Pubitemid 37186847)
11. Tang J, Wang G, Liu Y, Fu Y, Chi J, Zhu Y, Zhao Y, Yin X (2011) Cyclosporin A induces cardiomyocyte injury through calcium-sensing receptor-mediated calcium overload. Pharmazie 66:52-57
12. Wang M, Yao Y, Kuang D, Hampson DR (2006) Activation of family C G-protein coupled receptors by the tripeptide glutathione. J Biol Chem 281:8864-8870 (Pubitemid 43847993)
13. Sanela Smajilovic, Jacob Tfelt-Hansen (2008) Novel role of the calcium-sensing receptor in blood pressure modulation. Hypertension 52:994-1000
14. Wang R, Xu C, Zhao W, Zhang J, Cao K, Yang B, Wu L (2003) Calcium and polyamine regulated calcium sensing receptors incardiac tissues. Eur J Biochem 270:2680-2688 (Pubitemid 36733535)
15. Tfelt-Hansen J, Hansen JL, Smajilovic S, Terwilliger EF, Haunso S, Sheikh SP (2006) Calcium receptor is functionally expressedin rat neonatal ventricular cardiomyocytes. Am J Physiol HeartCirc Physiol 290:H1165-H1171
16. Zhang WH, Fu SB, Lu FH, Wu B, Gong DM, Pan ZW, Lv YJ,Zhao YJ, Li QF, Wang R, Yang BF, Xu CQ (2006) Involvementof calcium-sensing receptor in ischemia/reperfusion-inducedapoptosis in rat cardiomyocytes. Biochem Biophys Res Commun347:872-881 (Pubitemid 44118200)
17. Gao N, Budhraja A, Cheng S, Liu EH, Huang C, Chen J, Yang Z, Chen D, Zhang Z, Shi X (2011) Interruption of the MEK/ERKsignaling cascade promotes dihydroartemisinin-induced apoptosisin vitro and in vivo. Apoptosis 16:511-523
18. Hail N Jr, Carter BZ, Konopleva M, Andreeff M (2006) Apoptosis effector mechanisms: a requiem performed in different keys. Apoptosis 11:889-904 (Pubitemid 43880261)
19. Buggins AG, Pepper CJ (2010) The role of Bcl-2 family proteins in chronic lymphocytic leukaemia. Leuk Res 34:837-842
20. Gu X, Yao Y, Cheng R, Zhang Y, Dai Z, Wan G, Yang Z, Cai W, Gao G, Yang X (2011) Plasminogen K5 activates mitochondrial apoptosis pathway in endothelial cells by regulating Bak and Bclx(L) subcellular distribution. Apoptosis 16:846-855
21. Meyer Zu Schwabedissen HE, Grube M, Dreisbach A, Jedlitschky G, Meissner K, Linnemann K, Fusch C, Ritter CA, Völker U, Kroemer HK (2006) Epidermal growth factor (EGF) mediated activation of the MAP kinase cascade results in altered expression and function of ABCG2 (BCRP). Drug Metab Dispos 34:524-533
22. Roos TU, Heiss EH, Schwaiberger AV, Schachner D, Sroka IM, Oberan T, Vollmar AM, Dirsch VM (2011) Caffeic acid phenethyl ester inhibits PDGF-induced proliferation of vascular smooth muscle cells via activation of p38 MAPK, HIF-1α, and heme oxygenase-1. J Nat Prod 74:352-356
23. Miwa M, Kozawa O, Tokuda H, Uematsu T (1999) Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1) induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C. Endocrinology 140:5120-5125
24. Gao J, Li J, Ma L (2005) Regulation of EGF-induced ERK/ MAPK activation and EGFR internalization by Gprotein-coupled receptor kinase 2. Acta Biochim Biophys Sin 37:525-531 (Pubitemid 41608065)
25. Gripentrog JM, Miettinen HM (2005) Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis. Cell Signal 17:1300-1311 (Pubitemid 40982619)
26. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331
27. Kaminska B, Figiel I, Pyrzynska B, Czajkowski R, Mosieniak G (2001) Treatment of hippocampal neurons with cyclosporin A results in calcium overload and apoptosis which are independent on NMDA receptor activation. Br J Pharmacol 133:997-1004 (Pubitemid 32762408)
28. Florio S, Ciarcia R, Crispino L, Pagnini U, Ruocco A, Kumar C, D'Andrilli G, Russo F (2003) Hydrocortisone has a protective effect on cyclosporin A-induced cardiotoxicity. J Cell Physiol 195:21-26 (Pubitemid 36292756)
29. Adams JM, Cory S (2007) Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol 19:488-496 (Pubitemid 47487452)
30. Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205-219 (Pubitemid 38167313)
31. Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science 305:626-629 (Pubitemid 39006738)
32. Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH (2005) An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435:677-681 (Pubitemid 40825512)
33. Benadiba M, Dos Santos RR, Silva Dde O, Colquhoun A (2010) Inhibition of C6 rat glioma proliferation by [Ru2Cl(Ibp)4] depends on changes in p21, p27, Bax/Bcl2 ratio and mitochondrial membrane potential. J Inorg Biochem 104:928-935
34. Cargnello M, Roux PP (2011) Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev 75:50-83
35. Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22:954-965 (Pubitemid 351519953)
36. Liu HZ, Yu C, Yang Z, He JL, Chen WJ, Yin J, Li WM, Liu HT, Wang YX (2011) Tubeimoside I sensitizes cisplatin in cisplatin-resistant human ovarian cancer cells (A2780/DDP) through down-regulation of ERK and up-regulation of p38 signaling pathways. Mol Med Report 4:985-992