Cycle arrest and aneuploidy induced by zidovudine in murine embryonic stem cells

Mutagenesis

Volumn 27, Issue 4, 2012, Pages 431-436

  Campos, P B ^a,b   Sartore, R C ^a,b   Ramalho, B L ^a,b   Costa, E S ^a   Rehen, S K ^a,b  

^a Cidade Universitária Ilha do Fundão ^*  (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANEUPLOIDY; ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CHROMOSOMAL INSTABILITY; CHROMOSOME LOSS; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG EFFICACY; DRUG EXPOSURE; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; GENOTOXICITY; MICRONUCLEUS; MOUSE; NONHUMAN; PREGNANT WOMAN; PRIORITY JOURNAL; RISK REDUCTION; VERTICAL TRANSMISSION;

ANEUPLOIDY; ANIMALS; ANTI-HIV AGENTS; CELL CYCLE CHECKPOINTS; CELLS, CULTURED; EMBRYONIC STEM CELLS; FEMALE; MICE; PREGNANCY; ZIDOVUDINE;

MURINAE;

EID: 84863446132     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/ger093     Document Type: Article

References (40)

1. Mitsuya, H., Weinhold, K. J., Furman, P. A., St Clair, M. H., Lehrman, S. N., Gallo, R. C., Bolognesi, D., Barry, D. W. and Broder, S. (1985) 3′-Azido-3′-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc. Natl Acad. Sci. U. S. A., 82, 7096-7100. (Pubitemid 16209699)
2. Furman, P. A., Fyfe, J. A., St Clair, M. H. et al. (1986) Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl Acad. Sci. U. S. A., 83, 8333-8337. (Pubitemid 17182495)
3. Cooper, E. R., Charurat, M., Mofenson, L. et al. (2002) Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. J. Acquir. Immune. Defic. Syndr., 29, 484-494. (Pubitemid 34456340)
4. Vallier, L. and Pedersen, R. A. (2005) Human embryonic stem cells: an in vitro model to study mechanisms controlling pluripotency in early mammalian development. Stem Cell Rev., 1, 119-130. (Pubitemid 43074196)
5. Borojerdi, J. P., Ming, J., Cooch, C. et al. (2009) Centrosomal amplification and aneuploidy induced by the antiretroviral drug AZT in hamster and human cells. Mutat. Res., 665, 67-74.
6. Sukoyan, M. A., Kerkis, A. Y., Mello, M. R., Kerkis, I. E., Visintin, J. A. and Pereira, L. V. (2002) Establishment of new murine embryonic stem cell lines for the generation of mouse models of human genetic diseases. Braz. J. Med. Biol. Res., 35, 535-542. (Pubitemid 34568221)
7. Dutra, A., Pak, E., Wincovitch, S., John, K., Poirier, M. C. and Olivero, O. A. (2010) Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity. Cytogenet. Genome Res., 128, 105-110.
8. Von Tungeln, L. S., Williams, L. D., Doerge, D. R., Shaddock, J. G., McGarrity, L. J., Morris, S. M., Mittelstaedt, R. A., Heflich, R. H. and Beland, F. A. (2007) Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine. Environ. Mol. Mutagen., 48, 258-269. (Pubitemid 46536094)
9. Campos, P. B., Sartore, R. C., Abdalla, S. N. and Rehen, S. K. (2009) Chromosomal spread preparation of human embryonic stem cells for karyotyping. J. Vis. Exp., 31, e1512.
10. Wu, Q., Beland, F. A., Chang, C. W. and Fang, J. L. (2011) XPC is essential for nucleotide excision repair of zidovudine-induced DNA damage in human hepatoma cells. Toxicol. Appl. Pharmacol., 251, 155-162.
11. Fang, J. L., McGarrity, L. J. and Beland, F. A. (2009) Interference of cell cycle progression by zidovudine and lamivudine in NIH 3T3 cells. Mutagenesis, 24, 133-141.
12. Olivero, O. A., Tejera, A. M., Fernandez, J. J., Taylor, B. J., Das, S., Divi, R. L. and Poirier, M. C. (2005) Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis, 20, 139-146. (Pubitemid 40637814)
13. Olivero, O. A., Vazquez, I. L., Cooch, C. C. et al. (2010) Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells. Toxicol. Sci., 115, 109-117.
14. Krempler, A., Deckbar, D., Jeggo, P. A. and Lobrich, M. (2007) An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle, 6, 1682-1686. (Pubitemid 47327917)
15. Taapken, S. M., Nisler, B. S., Newton, M. A., Sampsell-Barron, T. L., Leonhard, K. A., McIntire, E. M. and Montgomery, K. D. (2011) Karotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells. Nat. Biotechnol., 29, 313-314.
16. Spits, C., Mateizel, I., Geens, M., Mertzanidou, A., Staessen, C., Vandeskelde, Y., Van der Elst, J., Liebaers, I. and Sermon, K. (2008) Recurrent chromosomal abnormalities in human embryonic stem cells. Nat. Biotechnol., 26, 1361-1363.
17. Catalina, P., Montes, R., Ligero, G., Sanchez, L., Cueva, T. D., Bueno, C., Leone, P. E. and Menendez, P. (2008) Human ESCs predisposition to karyotypic instability: is a matter of cell culture adaptation or differential vulnerability among hESC lines due to inherent properties? Mol. Cancer, 7, 76.
18. Peterson, S. E., Westra, J. W., Rehen, S. K. et al. (2011) Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy. PLoS One, 6, e23018.
19. Fluckiger, A. C., Marcy, G., Marchand, M., Negre, D., Cosset, F. L., Mitalipov, S., Wolf, D., Savatier, P. and Dehay, C. (2006) Cell cycle features of primate embryonic stem cells. Stem Cells, 24, 547-556. (Pubitemid 44464758)
20. Norppa, H. and Falck, G. C. (2003) What do human micronuclei contain? Mutagenesis, 18, 221-233. (Pubitemid 36592414)
21. Olivero, O. A., Parikka, R., Poirier, M. C. and Vahakangas, K. (1999) 3′-azido-3′-deoxythymidine (AZT) transplacental perfusion kinetics and DNA incorporation in normal human placentas perfused with AZT. Mutat. Res., 428, 41-47. (Pubitemid 29389675)
22. Witt, K. L., Cunningham, C. K., Patterson, K. B., Kissling, G. E., Dertinger, S. D., Livingston, E. and Bishop, J. B. (2007) Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV. Environ. Mol. Mutagen., 48, 322-329. (Pubitemid 46536099)
23. Poirier, M. C., Divi, R. L., Al-Harthi, L. et al. (2003) Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers. J. Acquir. Immune Defic. Syndr., 33, 175-183. (Pubitemid 36793152)
24. Olivero, O. A., Anderson, L. M., Diwan, B. A. et al. (1997) Transplacental effects of 3′-azido-2′,3′-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys. J. Natl. Cancer Inst., 89, 1602-1608. (Pubitemid 27479720)
25. Nyberg, K. A., Michelson, R. J., Putnam, C. W. and Weinert, T. A. (2002) Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet., 36, 617-656. (Pubitemid 36109200)
26. Firat, E., Gaedicke, S., Tsurumi, C., Esser, N., Weyerbrock, A. and Niedermann, G. (2011) Delayed cell death associated with mitotic catastrophe in gamma-irradiated stem-like glioma cells. Radiat. Oncol., 6, 71.
27. Vakifahmetoglu, H., Olsson, M. and Zhivotovsky, B. (2008) Death through a tragedy: mitotic catastrophe. Cell Death Differ., 15, 1153-1162. (Pubitemid 351850968)
28. Calogero, A. E., Burrello, N., De Palma, A., Barone, N., D'Agata, R. and Vicari, E. (2003) Sperm aneuploidy in infertile men. Reprod. Biomed. Online, 6, 310-317. (Pubitemid 36849775)
29. Vorsanova, S. G., Iurov, I., Kolotii, A. D. et al. (2010) [Chromosomal mosaicism in spontaneous abortions: analysis of 650 cases]. Genetika, 46, 1356-1359.
30. Iourov, I. Y., Vorsanova, S. G. and Yurov, Y. B. (2010) Somatic genome variations in health and disease. Curr. Genomics, 11, 387-396.
31. Ricke, R. M., van Ree, J. H. and van Deursen, J. M. (2008) Whole chromosome instability and cancer: a complex relationship. Trends Genet., 24, 457-466.
32. Walker, D. M., Malarkey, D. E., Seilkop, S. K. et al. (2007) Transplacental carcinogenicity of 3′-azido-3′-deoxythymidine in B6C3F1 mice and F344 rats. Environ. Mol. Mutagen., 48, 283-298. (Pubitemid 46536096)
33. Fenech, M., Kirsch-Volders, M., Natarajan, A. T. et al. (2011) Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. Mutagenesis, 26, 125-132.
34. Ford, J. H., Schultz, C. J. and Correll, A. T. (1988) Chromosome elimination in micronuclei: a common cause of hypoploidy. Am. J. Hum. Genet., 43, 733-740. (Pubitemid 18269254)
35. Dobrovolsky, V. N., Shaddock, J. G., Mittelstaedt, R. A. et al. (2007) Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p.53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC. Environ. Mol. Mutagen., 48, 270-282. (Pubitemid 46536095)
36. Chang, P., Li, Y. and Li, D. (2010) Micronuclei levels in peripheral blood lymphocytes as a potential biomarker for pancreatic cancer risk. Carcinogenesis, 32, 210-215.
37. Santos, R. A., Teixeira, A. C., Mayorano, M. B., Carrara, H. H., Andrade, J. M. and Takahashi, C. S. (2010) Basal levels of DNA damage detected by micronuclei and comet assays in untreated breast cancer patients and healthy women. Clin. Exp. Med., 10, 87-92.
38. Migliore, L., Coppede, F., Fenech, M. and Thomas, P. (2011) Association of micronucleus frequency with neurodegenerative diseases. Mutagenesis, 26, 85-92.
39. Payne, B. A., Wilson, I. J., Hateley, C. A., Horvath, R., Santibanez-Koref, M., Samuels, D. C., Price, D. A. and Chinnery, P. F. (2011) Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations. Nat Genet., 43, 726-727.
40. Baker, D. J., Jeganathan, K. B., Cameron, J. D. et al. (2004) BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat. Genet., 36, 744-749. (Pubitemid 38886637)