Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4593-4598

  Hartsel, Joshua A ^a   Wong, Dawn M ^a   Mutunga, James M ^a   Ma, Ming ^a   Anderson, Troy D ^a   Wysinski, Ania ^a   Islam, Rafique ^b   Wong, Eric A ^a   Paulson, Sally L ^a   Li, Jianyong ^a   Lam, Polo C H ^c   Totrov, Maxim M ^c   Bloomquist, Jeffrey R ^a,b   Carlier, Paul R ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c MOLSOFT LLC   (United States)

Author keywords

Acetylcholinesterase; Malaria; Mechanism based inactivator; Mosquito; Species selectivity

Indexed keywords

ACETYLCHOLINESTERASE; ARYLMETHYLCARBAMATE DERIVATIVE; BENDIOCARB; CARBAMIC ACID DERIVATIVE; CARBARIL; CARBOFURAN; PROPOXUR; UNCLASSIFIED DRUG;

ANOPHELES GAMBIAE; ARTICLE; CHEMICAL ENGINEERING; CHEMICAL STRUCTURE; ENZYME INHIBITION; HUMAN; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TOXICITY;

ACETYLCHOLINESTERASE; ANIMALS; ANOPHELES GAMBIAE; CARBAMATES; CHOLINESTERASE INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

ANOPHELES GAMBIAE;

EID: 84863442518     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.103     Document Type: Article

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