Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4703-4706

  Xiang, Yang Fei ^a   Qian, Chui Wen ^a   Xing, Guo Wen ^b   Hao, Jing ^a   Xia, Min ^a   Wang, Yi Fei ^a  

^a JINAN UNIVERSITY   (China)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Antivirals; Herpes simplex virus (HSV); HSP90 inhibitor

Indexed keywords

2 [(4 HYDROXYCYCLOHEXYL)AMINO] 4 (4,5,6,7 TETRAHYDRO 3,6,6 TRIMETHYL 4 OXO 1H INDAZOL 1 YL)BENZAMIDE; 2 [(4 HYDROXYCYCLOHEXYL)AMINO] 4 (4,5,6,7 TETRAHYDRO 3,6,6 TRIMETHYL 4 OXO 1H INDOL 1 YL)BENZAMIDE; 2 [(4 HYDROXYCYCLOHEXYL)AMINO] 4 [4,5,6,7 TETRAHYDRO 6,6 DIMETHYL 4 OXO 3 (TRIFLUOROMETHYL) 1H INDAZOL 1 YL]BENZAMIDE; 2 AMINOBENZAMIDE DERIVATIVE; ACICLOVIR; ANTIVIRUS AGENT; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; SNX 2112; SNX 25A; SNX 7081; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; GEL; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RABBIT; VERO CELL; VIRUS INFECTION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELL SURVIVAL; HERPESVIRUS 1, HUMAN; HSP90 HEAT-SHOCK PROTEINS; MOLECULAR STRUCTURE; ORTHO-AMINOBENZOATES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

HERPES; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; ORYCTOLAGUS CUNICULUS; SIMPLEXVIRUS;

EID: 84863441698     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.079     Document Type: Article

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