Flii neutralizing antibodies improve wound healing in porcine preclinical studies

Wound Repair and Regeneration

Volumn 20, Issue 4, 2012, Pages 523-536

  Jackson, Jessica E ^a   Kopecki, Zlatko ^a   Adams, Damian H ^a   Cowin, Allison J ^a,b  

^a CHILD HEALTH RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FLIGHTLESS I NEUTRALIZING MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; POLYURETHAN; PROTEIN; PROTEIN FLIGHTLESS I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIZATION; FEMALE; HISTOLOGY; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAR FORMATION; SURGICAL WOUND; SWINE; TENSILE STRENGTH; WOUND DRESSING; WOUND HEALING;

ACTINS; ANIMALS; ANTIBODIES, NEUTRALIZING; CELL PROLIFERATION; CICATRIX; COLLAGEN; CYTOSKELETAL PROTEINS; EPITHELIAL CELLS; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED BALB C; SWINE; TIME FACTORS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 84863439950     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2012.00802.x     Document Type: Article

References (38)

1. Amendt C, Mann A, Schirmacher P, Blessing M,. Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialisation in skin wounds. J Cell Sci 2002; 115: 2189-2198. (Pubitemid 34746384)
2. Saika S, Shiraishi A, Liu CY, Funderburgh JL, Kao CW, Converse RL, Kao WW,. Role of lumican in the corneal epithelium during wound healing. J Biol Chem 2000; 275: 2607-2612. (Pubitemid 30082027)
3. Longaker MT, Whitby DJ, Ferguson MW, Lorenz HP, Harrison MR, Adzick NS,. Adult skin wounds in the fetal environment heal with scar formation. Ann Surg 1994; 219: 65-72. (Pubitemid 24032239)
4. Temple CL, Ross DC, Dunning CE, Johnson JA, King GJ,. Tensile strength of healing peripheral nerves. J Reconstr Microsurg 2003; 19: 483-488. (Pubitemid 37255268)
5. McDougall S, Dallon J, Sherratt J, Maini P,. Fibroblast migration and collagen deposition during dermal wound healing: mathematical modelling and clinical implications. Philos Transact A Math Phys Eng Sci 2006; 364: 1385-1405. (Pubitemid 43893617)
6. Straub KL, Stella MC, Leptin M,. The gelsolin-related Flightless I protein is required for actin distribution during cellularisation in Drosophila. J Cell Sci 1996; 109: 263-270.
7. Goshima M, Kariya K, Yamawaki-Kataoka Y, Okada T, Shibatohge M, Shima F, Fujimoto E, Kataoka T,. Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains. Biochem Biophys Res Commun 1999; 257: 111-116. (Pubitemid 29299056)
8. Davy DA, Ball EE, Matthaei KI, Campbell HD, Crouch MF,. The Flightless I protein localizes to actin-based structures during embryonic development. Immunol Cell Biol 2000; 78: 423-429. (Pubitemid 30655568)
9. Davy DA, Campbell HD, Fountain S, De Jong D, Crouch MF,. The Flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases. J Cell Sci 2001; 114: 549-562. (Pubitemid 32186112)
10. Cowin AJ, Hatzirodos N, Teusner JT, Belford DA,. Differential effect of wounding on actin and its associated proteins, paxillin and gelsolin, in fetal skin explants. J Invest Dermatol 2003; 120: 1118-1129. (Pubitemid 36702926)
11. Fong KSK, De Couet HG,. Novel proteins interacting with the leucine-rich repeat domain of human Flightless-I identified by the yeast two-hybrid system. Genomics 1999; 58: 146-157. (Pubitemid 29275759)
12. Wilson SA, Brown EC, Kingsman AG, Kingsman SM,. TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of Flightless I. Nucleic Acids Res 1998; 26: 2460-2467.
13. Archer SK, Behm CA, Claudianos C, Campbell HD,. The flightless protein and the gelsolin family in nuclear hormone receptor-mediated signalling. Biochem Soc Trans 2004; 32: 940-942. (Pubitemid 39655510)
14. Lee YH, Campbell HD, Stallcup MR,. Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. Mol Cell Biol 2004; 24: 2103-2117. (Pubitemid 38248949)
15. Lee YH, Stallcup MR,. Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription. Nucleic Acids Res 2006; 34: 5052-5059. (Pubitemid 44742472)
16. Dai PG, Jeong SY, Yu YB, Leng T, Wu W, Xie L, Chan X,. Modulation of TLR signalling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. J Immunol 2009; 182: 3450-3460.
17. Wang TY, Chuang TH, Ronni T, Gu S, Du YC, Cai H, Sun HQ, Yin HL, Chen X,. Flightless I homology negatively modulates the TLR pathway. J Immunol 2006; 176: 1355-1362. (Pubitemid 43134277)
18. Deng H, Xia D, Fang B, Zhang H,. The flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development. Genetics 2007; 177: 847-860. (Pubitemid 350005637)
19. Seward ME, Easley CA, McLeod JJ, Myers AL, Tombes RM,. Flightless-I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMk-II. FEBS Lett 2008; 582: 2489-2495.
20. Li JY, Yin HL, Yuan JY,. Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. J Cell Biol 2008; 181: 321-333. (Pubitemid 351574556)
21. Cowin AJ, Adams DH, Strudwick XL, Chan H, Hooper JA, Sander GR, Rayner TE, Matthaei KI, Powell BC, Campbell HD,. Flightless I deficiency enhances wound repair by increasing cell migration and proliferation. J Pathol 2007; 211: 572-581. (Pubitemid 46502434)
22. Adams DH, Strudwick XL, Kopecki Z, Hooper-Jones JA, Matthaei KI, Campbell HD, Powell BC, Cowin AJ,. Gender specific effects on the actin-remodelling protein Flightless I and TGF-beta1 contribute to impaired wound healing in aged skin. Int J Biochem Cell Biol 2008; 40: 1555-1569.
23. Adams DH, Ruzehaji N, Strudwick XL, Greenwood JE, Campbell HD, Arkell R, Cowin AJ,. Attenuation of Flightless I, an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-beta-1 and TGF-beta3. Br J Dermatol 2009; 161: 326-336.
24. Kopecki Z, Arkell RM, Strudwick XL, Hirose M, Ludwig RJ, Kern JS, Bruckner-Tuderman L, Zillikens D, Murrell DF, Cowin AJ,. Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita. J Pathol 2011; 225: 401-413.
25. Kopecki Z, Arkell R, Powell BC, Cowin AJ,. Flightless I regulates hemidesmosome formation and integrin-mediated cellular adhesion and migration during wound repair. J Invest Dermatol 2009; 129: 2031-2045.
26. Kopecki Z, Luchetti MM, Adams DH, Strudwick X, Mantamadiotis T, Stoppacciaro A, Gabrielli A, Ramsay RG, Cowin AJ,. Collagen loss and impaired wound healing is associated with c-Myb deficiency. J Pathol 2007; 211: 251-261.
27. Fries RB, Wallace WA, Roy S, Kuppusamy P, Bergdall V, Gordillo GM, Melwin WS, Sen CK,. Dermal excisional wound healing in pigs following treatment with applied pure oxygen. Mutat Res 2005; 579: 172-181. (Pubitemid 41540141)
28. Chilcott RP, Stubbs B, Ashley Z,. Habituating pigs for in-pen, non-invasive biophysical skin analysis. Lab Anim 2001; 35: 230-235. (Pubitemid 32592310)
29. Huang K, Mitzner W, Rabold R, Schofield B, Lee H, Biswal S, Tankersley CG,. Variation in senescent-dependent lung changes in inbred mouse strains. J Appl Physiol 2007; 102: 1632-1639. (Pubitemid 46571061)
30. Beausang E, Floyd H, Orton CI, Ferguson MWJ,. A new quantitative scale for clinical scar assessment. Plast Reconstr Surg 1998; 102: 1954-1961. (Pubitemid 28518519)
31. Jiang L, He L, Fountoulakis M,. Comparison of protein precipitation methods for sample preparation prior to proteomic analysis. J Chromatogr A 2004; 1023: 317-320. (Pubitemid 37494806)
32. Duncan JA, Bond JS, Mason T, Ludlow A, Cridland P, O'Kane S, Ferguson MW,. Visual analogue scale scoring and ranking: a suitable and sensitive method for assessing scar quality? Plast Reconstr Surg 2006; 118: 909-918. (Pubitemid 44412923)
33. Alvarez OM, Mertz PM, Eaglstein WH,. The effect of occlusive dressings on collagen synthesis and re-epithelialisation in superficial wounds. J Surg Res 1983; 35: 142-148. (Pubitemid 14226831)
34. Brown GL, Nanney LB, Griffen J, Cramer AB, Yancey JM, Curtsinger LJ 3rd, Holtzin L, Schultz GS, Jurkiewicz MJ, Lynch JB,. Enhancement of wound healing by topical treatment with epidermal growth factor. N Engl J Med 1989; 321: 76-79. (Pubitemid 19170395)
35. Frank S, Stallmeyer B, Kampfer H, Kolb N, Pfeilschifter J,. Leptin enhances wound re-epithelialisation and constitutes a direct function of leptin in skin repair. J Clin Invest 2000; 106: 501-509. (Pubitemid 30666383)
36. Qiu C, Coutinho P, Frank S, Franke S, Law LY, Martin P, Green CR, Becker DL,. Targeting connexin43 expression accelerates the rate of wound repair. Curr Biol 2003; 13: 1697-1703. (Pubitemid 37216247)
37. Ferguson MW, Duncan J, Bond J, Bush J, Durani P, So K, Tayor L, Chantrey J, Mason T, James G, Laverty H, Occleston NL, Sattar A, Ludlow A, O'Kane S,. Prophylactic administration of avotermin for the improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies. Lancet 2009; 373: 1264-1274.
38. Bush J, Duncan JA, Bond JS, Durani P, So K, Mason T, O'Kane S, Ferguson MW,. Scar-improving efficacy of avotermin administered into the wound margins of skin incisions as evaluated by a randomized, double-blind, placebo-controlled, phase II clinicaltrial. Plast Reconstr Surg 2010; 126: 1604-1615.