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Volumn 71, Issue 10, 2012, Pages 855-863

Contrasting effects of haloperidol and lithium on rodent brain structure: A magnetic resonance imaging study with postmortem confirmation

Author keywords

Antipsychotic; brain volume; haloperidol; lithium; magnetic resonance imaging; schizophrenia

Indexed keywords

HALOPERIDOL; LITHIUM;

EID: 84863404151     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.12.004     Document Type: Article
Times cited : (89)

References (60)
  • 1
    • 79951503453 scopus 로고    scopus 로고
    • Long-term antipsychotic treatment and brain volumes: A longitudinal study of first-episode schizophrenia
    • B.C. Ho, N.C. Andreasen, S. Ziebell, R. Pierson, V. Magnotta Long-term antipsychotic treatment and brain volumes: A longitudinal study of first-episode schizophrenia Arch Gen Psychiatry 68 2011 128 137
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 128-137
    • Ho, B.C.1    Andreasen, N.C.2    Ziebell, S.3    Pierson, R.4    Magnotta, V.5
  • 3
    • 77953568012 scopus 로고    scopus 로고
    • Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: A longitudinal brain imaging study
    • I.K. Lyoo, S.R. Dager, J.E. Kim, S.J. Yoon, S.D. Friedman, D.L. Dunner Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: A longitudinal brain imaging study Neuropsychopharmacology 35 2010 1743 1750
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1743-1750
    • Lyoo, I.K.1    Dager, S.R.2    Kim, J.E.3    Yoon, S.J.4    Friedman, S.D.5    Dunner, D.L.6
  • 5
    • 0028141509 scopus 로고
    • Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs
    • M.H. Chakos, J.A. Lieberman, R.M. Bilder, M. Borenstein, G. Lerner, B. Bogerts Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs Am J Psychiatry 151 1994 1430 1436
    • (1994) Am J Psychiatry , vol.151 , pp. 1430-1436
    • Chakos, M.H.1    Lieberman, J.A.2    Bilder, R.M.3    Borenstein, M.4    Lerner, G.5    Bogerts, B.6
  • 6
    • 20144365633 scopus 로고    scopus 로고
    • Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: The AESOP study
    • P. Dazzan, K.D. Morgan, K. Orr, G. Hutchinson, X. Chitnis, J. Suckling Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the AESOP study Neuropsychopharmacology 30 2005 765 774
    • (2005) Neuropsychopharmacology , vol.30 , pp. 765-774
    • Dazzan, P.1    Morgan, K.D.2    Orr, K.3    Hutchinson, G.4    Chitnis, X.5    Suckling, J.6
  • 8
    • 77955054491 scopus 로고    scopus 로고
    • Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits
    • H. Tost, D.F. Braus, S. Hakimi, M. Ruf, C. Vollmert, F. Hohn Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits Nat Neurosci 13 2010 920 922
    • (2010) Nat Neurosci , vol.13 , pp. 920-922
    • Tost, H.1    Braus, D.F.2    Hakimi, S.3    Ruf, M.4    Vollmert, C.5    Hohn, F.6
  • 10
    • 36849076332 scopus 로고    scopus 로고
    • Progressive brain volume loss in schizophrenia over the course of the illness: Evidence of maturational abnormalities in early adulthood
    • N.E. van Haren, H.E. Hulshoff Pol, H.G. Schnack, W. Cahn, R. Brans, I. Carati Progressive brain volume loss in schizophrenia over the course of the illness: Evidence of maturational abnormalities in early adulthood Biol Psychiatry 63 2008 106 113
    • (2008) Biol Psychiatry , vol.63 , pp. 106-113
    • Van Haren, N.E.1    Hulshoff Pol, H.E.2    Schnack, H.G.3    Cahn, W.4    Brans, R.5    Carati, I.6
  • 12
    • 66649083292 scopus 로고    scopus 로고
    • A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients
    • G.J. Moore, B.M. Cortese, D.A. Glitz, C. Zajac-Benitez, J.A. Quiroz, T.W. Uhde A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients J Clin Psychiatry 70 2009 699 705
    • (2009) J Clin Psychiatry , vol.70 , pp. 699-705
    • Moore, G.J.1    Cortese, B.M.2    Glitz, D.A.3    Zajac-Benitez, C.4    Quiroz, J.A.5    Uhde, T.W.6
  • 14
    • 36348943483 scopus 로고    scopus 로고
    • Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: A longitudinal MRI study
    • K. Yucel, M.C. McKinnon, V.H. Taylor, K. Macdonald, M. Alda, L.T. Young Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: A longitudinal MRI study Psychopharmacology (Berl) 195 2007 357 367
    • (2007) Psychopharmacology (Berl) , vol.195 , pp. 357-367
    • Yucel, K.1    McKinnon, M.C.2    Taylor, V.H.3    MacDonald, K.4    Alda, M.5    Young, L.T.6
  • 15
    • 36949014949 scopus 로고    scopus 로고
    • Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment
    • K. Yucel, V.H. Taylor, M.C. McKinnon, K. Macdonald, M. Alda, L.T. Young Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment Neuropsychopharmacology 33 2008 361 367
    • (2008) Neuropsychopharmacology , vol.33 , pp. 361-367
    • Yucel, K.1    Taylor, V.H.2    McKinnon, M.C.3    MacDonald, K.4    Alda, M.5    Young, L.T.6
  • 16
    • 0037405871 scopus 로고    scopus 로고
    • Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: A suggested solution based on in vivo occupancy
    • S. Kapur, S.C. VanderSpek, B.A. Brownlee, J.N. Nobrega Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: A suggested solution based on in vivo occupancy J Pharmacol Exp Ther 305 2003 625 631
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 625-631
    • Kapur, S.1    Vanderspek, S.C.2    Brownlee, B.A.3    Nobrega, J.N.4
  • 17
    • 10844289845 scopus 로고    scopus 로고
    • Effect of chronic lithium treatment on glucocorticoid and 5-HT1A receptor messenger RNA in hippocampal and dorsal raphe nucleus regions of the rat brain
    • R. McQuade, M.M. Leitch, S.E. Gartside, A.H. Young Effect of chronic lithium treatment on glucocorticoid and 5-HT1A receptor messenger RNA in hippocampal and dorsal raphe nucleus regions of the rat brain J Psychopharmacol 18 2004 496 501
    • (2004) J Psychopharmacol , vol.18 , pp. 496-501
    • McQuade, R.1    Leitch, M.M.2    Gartside, S.E.3    Young, A.H.4
  • 18
    • 34548129274 scopus 로고    scopus 로고
    • The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics
    • K.C. O'Donnell, T.D. Gould The behavioral actions of lithium in rodent models: leads to develop novel therapeutics Neurosci Biobehav Rev 31 2007 932 962
    • (2007) Neurosci Biobehav Rev , vol.31 , pp. 932-962
    • O'Donnell, K.C.1    Gould, T.D.2
  • 19
    • 79955474356 scopus 로고    scopus 로고
    • Effect of chronic antipsychotic treatment on brain structure: A serial magnetic resonance imaging study with ex vivo and postmortem confirmation
    • A.C. Vernon, S. Natesan, M. Modo, S. Kapur Effect of chronic antipsychotic treatment on brain structure: A serial magnetic resonance imaging study with ex vivo and postmortem confirmation Biol Psychiatry 69 2011 936 944
    • (2011) Biol Psychiatry , vol.69 , pp. 936-944
    • Vernon, A.C.1    Natesan, S.2    Modo, M.3    Kapur, S.4
  • 20
    • 19544370569 scopus 로고    scopus 로고
    • Comparing rat's to human's age: How old is my rat in people years?
    • R. Quinn Comparing rat's to human's age: How old is my rat in people years? Nutrition 21 2005 775 777
    • (2005) Nutrition , vol.21 , pp. 775-777
    • Quinn, R.1
  • 21
    • 0037207798 scopus 로고    scopus 로고
    • The relationship between dopamine D2 receptor occupancy and the vacuous chewing movement syndrome in rats
    • P. Turrone, G. Remington, S. Kapur, J.N. Nobrega The relationship between dopamine D2 receptor occupancy and the vacuous chewing movement syndrome in rats Psychopharmacology (Berl) 165 2003 166 171
    • (2003) Psychopharmacology (Berl) , vol.165 , pp. 166-171
    • Turrone, P.1    Remington, G.2    Kapur, S.3    Nobrega, J.N.4
  • 22
    • 33846334440 scopus 로고    scopus 로고
    • Effect of lithium and lithium withdrawal on potassium-evoked dopamine release and tyrosine hydroxylase expression in the rat
    • L. Ferrie, A.H. Young, R. McQuade Effect of lithium and lithium withdrawal on potassium-evoked dopamine release and tyrosine hydroxylase expression in the rat Int J Neuropsychopharmacol 9 2006 729 735
    • (2006) Int J Neuropsychopharmacol , vol.9 , pp. 729-735
    • Ferrie, L.1    Young, A.H.2    McQuade, R.3
  • 23
    • 0036844184 scopus 로고    scopus 로고
    • Self-reported adherence to treatment with mood stabilizers, plasma levels, and psychiatric hospitalization
    • J. Scott, M. Pope Self-reported adherence to treatment with mood stabilizers, plasma levels, and psychiatric hospitalization Am J Psychiatry 159 2002 1927 1929
    • (2002) Am J Psychiatry , vol.159 , pp. 1927-1929
    • Scott, J.1    Pope, M.2
  • 24
    • 25844453682 scopus 로고    scopus 로고
    • Joint Formulary Committee 61st ed. BMJ Publishing Group Ltd and Royal Pharmaceutical Society London
    • Joint Formulary Committee British National Formulary (BNF) 61st ed. 2011 BMJ Publishing Group Ltd and Royal Pharmaceutical Society London
    • (2011) British National Formulary (BNF)
  • 25
    • 79952122662 scopus 로고    scopus 로고
    • Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease
    • A.C. Vernon, W.R. Crum, S.M. Johansson, M. Modo Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease PLoS One 6 2011 e17269
    • (2011) PLoS One , vol.6 , pp. 17269
    • Vernon, A.C.1    Crum, W.R.2    Johansson, S.M.3    Modo, M.4
  • 27
    • 0036697383 scopus 로고    scopus 로고
    • Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI
    • O.T. Wolf, V. Dyakin, C. Vadasz, M.J. de Leon, B.S. McEwen, K. Bulloch Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI Brain Res Brain Res Protoc 10 2002 41 46
    • (2002) Brain Res Brain Res Protoc , vol.10 , pp. 41-46
    • Wolf, O.T.1    Dyakin, V.2    Vadasz, C.3    De Leon, M.J.4    McEwen, B.S.5    Bulloch, K.6
  • 28
    • 33751349970 scopus 로고    scopus 로고
    • Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis
    • C. Kielar, L. Maddox, E. Bible, C.C. Pontikis, S.L. Macauley, M.A. Griffey Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis Neurobiol Dis 25 2007 150 162
    • (2007) Neurobiol Dis , vol.25 , pp. 150-162
    • Kielar, C.1    Maddox, L.2    Bible, E.3    Pontikis, C.C.4    MacAuley, S.L.5    Griffey, M.A.6
  • 29
    • 84985280160 scopus 로고
    • The efficiency of systematic sampling in stereology and its prediction
    • H.J. Gundersen, E.B. Jensen The efficiency of systematic sampling in stereology and its prediction J Microsc 147 1987 229 263
    • (1987) J Microsc , vol.147 , pp. 229-263
    • Gundersen, H.J.1    Jensen, E.B.2
  • 30
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator
    • M.J. West, L. Slomianka, H.J. Gundersen Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator Anat Rec 231 1991 482 497
    • (1991) Anat Rec , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 32
    • 0036289385 scopus 로고    scopus 로고
    • Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs
    • C. Andersson, R.M. Hamer, C.P. Lawler, R.B. Mailman, J.A. Lieberman Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs Neuropsychopharmacology 27 2002 143 151
    • (2002) Neuropsychopharmacology , vol.27 , pp. 143-151
    • Andersson, C.1    Hamer, R.M.2    Lawler, C.P.3    Mailman, R.B.4    Lieberman, J.A.5
  • 34
    • 0030613524 scopus 로고    scopus 로고
    • The relationship between D2 receptor occupancy and plasma levels on low dose oral haloperidol: A PET study
    • S. Kapur, R. Zipursky, P. Roy, C. Jones, G. Remington, K. Reed The relationship between D2 receptor occupancy and plasma levels on low dose oral haloperidol: A PET study Psychopharmacology 131 1997 148 152
    • (1997) Psychopharmacology , vol.131 , pp. 148-152
    • Kapur, S.1    Zipursky, R.2    Roy, P.3    Jones, C.4    Remington, G.5    Reed, K.6
  • 36
    • 77954142687 scopus 로고    scopus 로고
    • Progressive lateral ventricular enlargement in schizophrenia: A meta-analysis of longitudinal MRI studies
    • M.J. Kempton, D. Stahl, S.C. Williams, L.E. DeLisi Progressive lateral ventricular enlargement in schizophrenia: A meta-analysis of longitudinal MRI studies Schizophr Res 120 2010 54 62
    • (2010) Schizophr Res , vol.120 , pp. 54-62
    • Kempton, M.J.1    Stahl, D.2    Williams, S.C.3    Delisi, L.E.4
  • 37
    • 0032924127 scopus 로고    scopus 로고
    • The neuropathology of schizophrenia A critical review of the data and their interpretation
    • P.J. Harrison The neuropathology of schizophrenia A critical review of the data and their interpretation Brain 122 1999 593 624
    • (1999) Brain , vol.122 , pp. 593-624
    • Harrison, P.J.1
  • 38
    • 36148945237 scopus 로고    scopus 로고
    • Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study
    • E.S. Monkul, K. Matsuo, M.A. Nicoletti, N. Dierschke, J.P. Hatch, M. Dalwani Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study Neurosci Lett 429 2007 7 11
    • (2007) Neurosci Lett , vol.429 , pp. 7-11
    • Monkul, E.S.1    Matsuo, K.2    Nicoletti, M.A.3    Dierschke, N.4    Hatch, J.P.5    Dalwani, M.6
  • 39
    • 79151472847 scopus 로고    scopus 로고
    • Structural magnetic resonance imaging in bipolar disorder: An international collaborative mega-analysis of individual adult patient data
    • B. Hallahan, J. Newell, J.C. Soares, P. Brambilla, S.M. Strakowski, D.E. Fleck Structural magnetic resonance imaging in bipolar disorder: An international collaborative mega-analysis of individual adult patient data Biol Psychiatry 69 2011 326 335
    • (2011) Biol Psychiatry , vol.69 , pp. 326-335
    • Hallahan, B.1    Newell, J.2    Soares, J.C.3    Brambilla, P.4    Strakowski, S.M.5    Fleck, D.E.6
  • 40
    • 50949102049 scopus 로고    scopus 로고
    • Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder
    • M.J. Kempton, J.R. Geddes, U. Ettinger, S.C. Williams, P.M. Grasby Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder Arch Gen Psychiatry 65 2008 1017 1032
    • (2008) Arch Gen Psychiatry , vol.65 , pp. 1017-1032
    • Kempton, M.J.1    Geddes, J.R.2    Ettinger, U.3    Williams, S.C.4    Grasby, P.M.5
  • 42
    • 42049099907 scopus 로고    scopus 로고
    • Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder
    • C.E. Bearden, P.M. Thompson, R.A. Dutton, B.N. Frey, M.A. Peluso, M. Nicoletti Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder Neuropsychopharmacology 33 2008 1229 1238
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1229-1238
    • Bearden, C.E.1    Thompson, P.M.2    Dutton, R.A.3    Frey, B.N.4    Peluso, M.A.5    Nicoletti, M.6
  • 43
    • 0021988597 scopus 로고
    • The effects of haloperidol on synaptic patterns in the rat striatum
    • F.M. Benes, P.A. Paskevich, J. Davidson, V.B. Domesick The effects of haloperidol on synaptic patterns in the rat striatum Brain Res 329 1985 265 273
    • (1985) Brain Res , vol.329 , pp. 265-273
    • Benes, F.M.1    Paskevich, P.A.2    Davidson, J.3    Domesick, V.B.4
  • 44
    • 0035890854 scopus 로고    scopus 로고
    • Antipsychotic drugs and neuroplasticity: Insights into the treatment and neurobiology of schizophrenia
    • C. Konradi, S. Heckers Antipsychotic drugs and neuroplasticity: Insights into the treatment and neurobiology of schizophrenia Biol Psychiatry 50 2001 729 742
    • (2001) Biol Psychiatry , vol.50 , pp. 729-742
    • Konradi, C.1    Heckers, S.2
  • 45
    • 79952441953 scopus 로고    scopus 로고
    • Brain volume changes after withdrawal of atypical antipsychotics in patients with first-episode schizophrenia
    • G. Boonstra, N.E. van Haren, H.G. Schnack, W. Cahn, H. Burger, M. Boersma Brain volume changes after withdrawal of atypical antipsychotics in patients with first-episode schizophrenia J Clin Psychopharmacol 31 2011 146 153
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 146-153
    • Boonstra, G.1    Van Haren, N.E.2    Schnack, H.G.3    Cahn, W.4    Burger, H.5    Boersma, M.6
  • 46
    • 80052843452 scopus 로고    scopus 로고
    • Progressive brain change in schizophrenia: A prospective longitudinal study of first-episode schizophrenia
    • N.C. Andreasen, P. Nopoulos, V. Magnotta, R. Pierson, S. Ziebell, B.C. Ho Progressive brain change in schizophrenia: A prospective longitudinal study of first-episode schizophrenia Biol Psychiatry 70 2011 672 679
    • (2011) Biol Psychiatry , vol.70 , pp. 672-679
    • Andreasen, N.C.1    Nopoulos, P.2    Magnotta, V.3    Pierson, R.4    Ziebell, S.5    Ho, B.C.6
  • 47
    • 79958858244 scopus 로고    scopus 로고
    • Are there progressive brain changes in schizophrenia? A meta-analysis of structural magnetic resonance imaging studies
    • B. Olabi, I. Ellison-Wright, A.M. McIntosh, S.J. Wood, E. Bullmore, S.M. Lawrie Are there progressive brain changes in schizophrenia? A meta-analysis of structural magnetic resonance imaging studies Biol Psychiatry 70 2011 88 96
    • (2011) Biol Psychiatry , vol.70 , pp. 88-96
    • Olabi, B.1    Ellison-Wright, I.2    McIntosh, A.M.3    Wood, S.J.4    Bullmore, E.5    Lawrie, S.M.6
  • 48
    • 0017330361 scopus 로고
    • The influence of lithium on water binding ability, consistency and macromolecules in the rat brain
    • S. Edelfors The influence of lithium on water binding ability, consistency and macromolecules in the rat brain Acta Pharmacol Toxicol (Copenh) 40 1977 126 133
    • (1977) Acta Pharmacol Toxicol (Copenh) , vol.40 , pp. 126-133
    • Edelfors, S.1
  • 50
    • 0345690100 scopus 로고    scopus 로고
    • Half a century of antipsychotics and still a central role for dopamine D2 receptors
    • S. Kapur, D. Mamo Half a century of antipsychotics and still a central role for dopamine D2 receptors Prog Neuropsychopharmacol Biol Psychiatry 27 2003 1081 1090
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 1081-1090
    • Kapur, S.1    Mamo, D.2
  • 51
    • 33947303207 scopus 로고    scopus 로고
    • "Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time
    • A.N. Samaha, P. Seeman, J. Stewart, H. Rajabi, S. Kapur "Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time J Neurosci 27 2007 2979 2986
    • (2007) J Neurosci , vol.27 , pp. 2979-2986
    • Samaha, A.N.1    Seeman, P.2    Stewart, J.3    Rajabi, H.4    Kapur, S.5
  • 54
  • 56
    • 0032967531 scopus 로고    scopus 로고
    • The reduced neuropil hypothesis: A circuit based model of schizophrenia
    • L.D. Selemon, P.S. Goldman-Rakic The reduced neuropil hypothesis: A circuit based model of schizophrenia Biol Psychiatry 45 1999 17 25
    • (1999) Biol Psychiatry , vol.45 , pp. 17-25
    • Selemon, L.D.1    Goldman-Rakic, P.S.2
  • 57
    • 0009789399 scopus 로고    scopus 로고
    • Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: A role for neurotrophic and neuroprotective effects in manic depressive illness
    • H.K. Manji, G.J. Moore, G. Chen Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness J Clin Psychiatry 61 9 suppl 2000 82 96
    • (2000) J Clin Psychiatry , vol.61 , Issue.9 SUPPL. , pp. 82-96
    • Manji, H.K.1    Moore, G.J.2    Chen, G.3
  • 58
    • 77951943796 scopus 로고    scopus 로고
    • Novel insights into lithium's mechanism of action: Neurotrophic and neuroprotective effects
    • J.A. Quiroz, R. Machado-Vieira, C.A. Zarate Jr, H.K. Manji Novel insights into lithium's mechanism of action: Neurotrophic and neuroprotective effects Neuropsychobiology 62 2010 50 60
    • (2010) Neuropsychobiology , vol.62 , pp. 50-60
    • Quiroz, J.A.1    MacHado-Vieira, R.2    Zarate, Jr.C.A.3    Manji, H.K.4
  • 59
    • 70350721661 scopus 로고    scopus 로고
    • Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia
    • Y. Piontkewitz, Y. Assaf, I. Weiner Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia Biol Psychiatry 66 2009 1038 1046
    • (2009) Biol Psychiatry , vol.66 , pp. 1038-1046
    • Piontkewitz, Y.1    Assaf, Y.2    Weiner, I.3


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