Intravitreal injection of erythropoietin glycosylation analogs does not protect rod photoreceptor cells from light-induced damage

Advances in Experimental Medicine and Biology

Volumn 723, Issue , 2012, Pages 137-143

  Tanito, Masaki ^a,b,c   Li, Feng ^a,b   Anderson, Robert E ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

Electroretinogram; Erythropoietin; Outer Nuclear Layer Thickness; Retinal Light Damage

Indexed keywords

AMG 114; ERYTHROPOIETIN; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; B WAVE; CELL DAMAGE; CELL PROTECTION; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRORETINOGRAPHY; EYE PROTECTION; LIGHT EXPOSURE; NONHUMAN; OUTER NUCLEAR LAYER THICKNESS; PHOTORECEPTOR CELL; PRIORITY JOURNAL; RAT; RETINA DEGENERATION; RETINA INJURY; RETINA ROD; SENSORY SYSTEM ELECTROPHYSIOLOGY; TREATMENT RESPONSE; VISUAL SYSTEM PARAMETERS;

ANIMALS; ELECTRORETINOGRAPHY; ERYTHROPOIETIN; GLYCOSYLATION; HEMATINICS; INTRAVITREAL INJECTIONS; LIGHT; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RETINAL DEGENERATION; RETINAL ROD PHOTORECEPTOR CELLS; TREATMENT FAILURE;

RATTUS;

EID: 84863395494     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-0631-0_19     Document Type: Conference Paper

References (13)

1. Arcasoy MO (2008) The non-haematopoietic biological effects of erythropoietin. Br J Haematol 141:14-31 (Pubitemid 351347536)
2. Faktorovich EG, Steinberg RH, Yasumura D et al (1992) Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat. J Neurosci 12:3554-3567
3. Grimm C, Wenzel A, Groszer M et al (2002) HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med 8:718-724 (Pubitemid 34778725)
4. Grimm C, Wenzel A, Stanescu D et al (2004) Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci 24:5651-5658 (Pubitemid 38857219)
5. Noell WK, Walker VS, Kang BS et al (1966) Retinal damage by light in rats. Invest Ophthalmol 5:450-473
6. Ranchon Cole I, Bonhomme B, Doly M (2007) Pre-treatment of adult rats with high doses of erythropoietin induces caspase-9 but prevents light-induced retinal injury. Exp Eye Res 85:782-789 (Pubitemid 350176578)
7. Rex TS, Allocca M, Domenici L et al (2004) Systemic but not intraocular Epo gene transfer protects the retina from light-and genetic-induced degeneration. Mol Ther 10:855-861 (Pubitemid 39419912)
8. Sinclair AM, Coxon A, McCaffery I et al (2010) Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells. Blood 115:4264-4272
9. Swift S, Ellison AR, Kassner P et al (2010) Absence of functional EpoR expression in human tumor cell lines. Blood 115:4254-4263
10. Tanito M, Kaidzu S, Ohira A et al (2008) Topography of retinal damage in light-exposed albino rats. Exp Eye Res 87:292-295
11. Tanito M, Li F, Elliott MH et al (2007) Protective effect of TEMPOL derivatives against lightinduced retinal damage in rats. Invest Ophthalmol Vis Sci 48:1900-1905 (Pubitemid 351261380)
12. Wen R, Song Y, Cheng T et al (1995) Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. J Neurosci 15:7377-7385
13. Wenzel A, Grimm C, Samardzija M et al (2005) Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res 24:275-306 (Pubitemid 40021788)