Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatus

Infection and Immunity

Volumn 80, Issue 1, 2012, Pages 410-417

  Gessner, Melissa A ^a   Werner, Jessica L ^a   Lilly, Lauren M ^a   Nelson, Michael P ^a   Metz, Allison E ^a   Dunaway, Chad W ^a   Chan, Yvonne R ^b   Ouyang, Wenjun ^c   Brown, Gordon D ^d   Weaver, Casey T ^e   Steele, Chad ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c GENENTECH INC   (United States)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DECTIN 1; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROTEIN S 100; REG3G PROTEIN; S100ALPHA8 PROTEIN; S100ALPHA9 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; LECTIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LUNG ALVEOLUS CELL; LUNG CLEARANCE; LUNG INFECTION; LUNG LAVAGE; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROVOCATION TEST; WILD TYPE; ANIMAL; BACTERIAL COUNT; C57BL MOUSE; CELL CULTURE; IMMUNOLOGY; LUNG; LUNG ASPERGILLOSIS; METABOLISM; MICROBIOLOGY; MOUSE MUTANT;

ANIMALS; ASPERGILLUS FUMIGATUS; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; COLONY COUNT, MICROBIAL; INTERLEUKINS; LECTINS, C-TYPE; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PULMONARY ASPERGILLOSIS;

EID: 84863393493     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05939-11     Document Type: Article

References (50)

1. Alangaden GJ. 2011. Nosocomial fungal infections: epidemiology, infection control, and prevention. Infect. Dis. Clin. North Am. 25:201-225.
2. Aujla SJ, et al. 2008. IL-22 mediates mucosal host defense against Gramnegative bacterial pneumonia. Nat. Med. 14:275-281.
3. Bachmann M, et al. 2010. Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1. PLoS Pathog. 6:e1001144.
4. Berger T, et al. 2006. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc. Natl. Acad. Sci. U. S. A. 103:1834 -1839.
5. Bowman JC, et al. 2001. Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate. Antimicrob. Agents Chemother. 45:3474 -3481.
6. Cella M, et al. 2009. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 457:722-725.
7. Cho JS, et al. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J. Clin. Invest. 120:1762-1773.
8. Conti HR, et al. 2009. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206: 299-311.
9. Crawford MA, et al. 2010. Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. PLoS Pathog. 6:e1001199.
10. De Luca A, et al. 2010. IL-22 defines a novel immune pathway of antifungal resistance. Mucosal Immunol. 3:361-373.
11. Elson CO, et al. 2007. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132: 2359-2370.
12. Gaffen SL. 2009. Structure and signalling in the IL-17 receptor family. Nat. Rev. Immunol. 9:556 -567.
13. Gao JL, et al. 1997. Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J. Exp. Med. 185:1959 -1968.
14. Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. 2009. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm. Allergy Drug Targets 8:40 -52.
15. Graham AC, et al. 2011. IL-22 production is regulated by IL-23 during Listeria monocytogenes infection but is not required for bacterial clearance or tissue protection. PLoS One 6:e17171.
16. Hamada S, et al. 2008. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver. J. Immunol. 181:3456 -3463.
17. Happel KI, et al. 2005. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J. Exp. Med. 202:761-769.
18. Kagami S, Rizzo HL, Kurtz SE, Miller LS, Blauvelt A. 2010. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans. J. Immunol. 185:5453-5462.
19. Kontoyiannis DP, Bodey GP. 2002. Invasive aspergillosis in 2002: an update. Eur. J. Clin. Microbiol. Infect. Dis. 21:161-172.
20. Kontoyiannis DP, et al. 2010. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin. Infect. Dis. 50:1091-1100.
21. Korn T, Bettelli E, Oukka M, Kuchroo VK. 2009. IL-17 and Th17 cells. Annu. Rev. Immunol. 27:485-517.
22. Kullberg MC, et al. 2006. IL-23 plays a key role in Helicobacter hepaticusinduced T cell-dependent colitis. J. Exp. Med. 203:2485-2494.
23. Langrish CL, et al. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201:233-240.
24. Liang SC, et al. 2006. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203:2271-2279.
25. Lin Y, et al. 2009. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 31:799-810.
26. Mangan PR, et al. 2006. Transforming growth factor-beta induces development of the TH17 lineage. Nature 441:231-234.
27. Martin B, Hirota K, Cua DJ, Stockinger B, Veldhoen M. 2009. Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 31: 321-330.
28. Mattila PE, Metz AE, Rapaka RR, Bauer LD, Steele C. 2008. Dectin-1 Fc targeting of Aspergillus fumigatus beta-glucans augments innate defense against invasive pulmonary aspergillosis. Antimicrob. Agents Chemother 52:1171-1172.
29. McGeachy MJ, et al. 2007. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 8:1390 -1397.
30. Mehrad B, Strieter RM, Standiford TJ. 1999. Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis. J. Immunol. 162: 1633-1640.
31. Nelson MP, Metz AE, Li S, Lowell CA, Steele C. 2009. The absence of Hck, Fgr and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina. Infect. Immun. 77:1790 -1797.
32. O'Connor W Jr, et al. 2009. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat. Immunol. 10:603- 609.
33. Pappas PG, et al. 2010. Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin. Infect. Dis. 50:1101-1111.
34. Pestka S, et al. 2004. Interleukin-10 and related cytokines and receptors. Annu. Rev. Immunol. 22:929 -979.
35. Schrettl M, et al. 2007. Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog. 3:1195-1207.
36. Schulz SM, et al. 2008. Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. J. Immunol. 181: 7891-7901.
37. Sonnenberg GF, Fouser LA, Artis D. 2011. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat. Immunol. 12:383-390.
38. Steele C, et al. 2005. The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog. 1:e42.
39. Sugimoto K, et al. 2008. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118:534 -544.
40. Takatori H, et al. 2009. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J. Exp. Med. 206:35- 41.
41. Taylor PR, et al. 2007. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat. Immunol. 8:31-38.
42. Werner J, et al. 2009. Requisite role for the Dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J. Immunol. 182: 4938-4946.
43. Werner JL, et al. 2011. Neutrophils produce IL-17A in a Dectin-1 and IL-23 dependent manner during invasive fungal infection. Infect. Immun. 79:3966 -3977.
44. Wolk K, Kunz S, Asadullah K, Sabat R. 2002. Cutting edge: immune cells as sources and targets of the IL-10 family members? J. Immunol. 168: 5397-5402.
45. Wolk K, et al. 2004. IL-22 increases the innate immunity of tissues. Immunity 21:241-254.
46. Zarember KA, Sugui JA, Chang YC, Kwon-Chung KJ, Gallin JI. 2007. Human polymorphonuclear leukocytes inhibit Aspergillus fumigatus conidial growth by lactoferrin-mediated iron depletion. J. Immunol. 178: 6367-6373.
47. Zenewicz L, et al. 2007. Interleukin-22 but not Interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27: 647-659.
48. Zenewicz LA, et al. 2008. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29:947-957.
49. H17 cytokine, mediates IL-23- induced dermal inflammation and acanthosis. Nature 445:648-651.
50. Zheng Y, et al. 2008. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14:282-289.