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Volumn 18, Issue 5, 2008, Pages 435-440

Context-dependent regulation of Groucho/TLE-mediated repression

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; GROUCHO PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 56049107271     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2008.07.010     Document Type: Review
Times cited : (70)

References (53)
  • 1
    • 0029895168 scopus 로고    scopus 로고
    • Transcriptional repression in development
    • Gray S., and Levine M. Transcriptional repression in development. Curr Opin Cell Biol 8 (1996) 358-364
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 358-364
    • Gray, S.1    Levine, M.2
  • 2
    • 0033597438 scopus 로고    scopus 로고
    • Transcriptional coregulators in development
    • Mannervik M., Nibu Y., Zhang H., and Levine M. Transcriptional coregulators in development. Science 284 (1999) 606-609
    • (1999) Science , vol.284 , pp. 606-609
    • Mannervik, M.1    Nibu, Y.2    Zhang, H.3    Levine, M.4
  • 3
    • 0035499392 scopus 로고    scopus 로고
    • Transcriptional repression: the long and the short of it
    • Courey A.J., and Jia S. Transcriptional repression: the long and the short of it. Genes Dev 15 (2001) 2786-2796
    • (2001) Genes Dev , vol.15 , pp. 2786-2796
    • Courey, A.J.1    Jia, S.2
  • 4
    • 33744792310 scopus 로고    scopus 로고
    • Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
    • Rosenfeld M.G., Lunyak V.V., and Glass C.K. Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev 20 (2006) 1405-1428
    • (2006) Genes Dev , vol.20 , pp. 1405-1428
    • Rosenfeld, M.G.1    Lunyak, V.V.2    Glass, C.K.3
  • 5
    • 0026005523 scopus 로고
    • Two genetically and molecularly distinct functions involved in early neurogenesis reside within the enhancer of split locus of Drosophila melanogaster
    • Delidakis C., Preiss A., Hartley D.A., and Artavanis-Tsakonas S. Two genetically and molecularly distinct functions involved in early neurogenesis reside within the enhancer of split locus of Drosophila melanogaster. Genetics 129 (1991) 803-823
    • (1991) Genetics , vol.129 , pp. 803-823
    • Delidakis, C.1    Preiss, A.2    Hartley, D.A.3    Artavanis-Tsakonas, S.4
  • 6
    • 0028170530 scopus 로고
    • Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
    • Paroush Z., Finley Jr. R.L., Kidd T., Wainwright S.M., Ingham P.W., Brent R., and Ish-Horowicz D. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 79 (1994) 805-815
    • (1994) Cell , vol.79 , pp. 805-815
    • Paroush, Z.1    Finley Jr., R.L.2    Kidd, T.3    Wainwright, S.M.4    Ingham, P.W.5    Brent, R.6    Ish-Horowicz, D.7
  • 7
    • 0032127990 scopus 로고    scopus 로고
    • Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates
    • Fisher A.L., and Caudy M. Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates. Genes Dev 12 (1998) 1931-1940
    • (1998) Genes Dev , vol.12 , pp. 1931-1940
    • Fisher, A.L.1    Caudy, M.2
  • 8
    • 0034673929 scopus 로고    scopus 로고
    • Groucho/TLE family proteins and transcriptional repression
    • Chen G., and Courey A.J. Groucho/TLE family proteins and transcriptional repression. Gene 249 (2000) 1-16
    • (2000) Gene , vol.249 , pp. 1-16
    • Chen, G.1    Courey, A.J.2
  • 9
    • 0030010697 scopus 로고    scopus 로고
    • The WRPW motif of the Hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain
    • Fisher A.L., Ohsako S., and Caudy M. The WRPW motif of the Hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol Cell Biol 16 (1996) 2670-2677
    • (1996) Mol Cell Biol , vol.16 , pp. 2670-2677
    • Fisher, A.L.1    Ohsako, S.2    Caudy, M.3
  • 10
    • 0030601067 scopus 로고    scopus 로고
    • Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif
    • Grbavec D., and Stifani S. Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif. Biochem Biophys Res Commun 223 (1996) 701-705
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 701-705
    • Grbavec, D.1    Stifani, S.2
  • 11
    • 0030701604 scopus 로고    scopus 로고
    • Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed
    • Jiménez G., Paroush Z., and Ish-Horowicz D. Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev 11 (1997) 3072-3082
    • (1997) Genes Dev , vol.11 , pp. 3072-3082
    • Jiménez, G.1    Paroush, Z.2    Ish-Horowicz, D.3
  • 13
    • 33744514127 scopus 로고    scopus 로고
    • Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor
    • This work elucidates the mechanism at the basis of Gro/TLE recognition by DNA-binding repressors. It provides genetic, biochemical, and structural evidence showing that both the WRPW and eh1 Gro-recruitment motifs, found in DNA-binding repressors, interact specifically with the same pore region of the C-terminal WD beta-propeller domain of Gro/TLE.
    • Jennings B.H., Pickles L.M., Wainwright S.M., Roe S.M., Pearl L.H., and Ish-Horowicz D. Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Mol Cell 22 (2006) 645-655. This work elucidates the mechanism at the basis of Gro/TLE recognition by DNA-binding repressors. It provides genetic, biochemical, and structural evidence showing that both the WRPW and eh1 Gro-recruitment motifs, found in DNA-binding repressors, interact specifically with the same pore region of the C-terminal WD beta-propeller domain of Gro/TLE.
    • (2006) Mol Cell , vol.22 , pp. 645-655
    • Jennings, B.H.1    Pickles, L.M.2    Wainwright, S.M.3    Roe, S.M.4    Pearl, L.H.5    Ish-Horowicz, D.6
  • 14
    • 0030720332 scopus 로고    scopus 로고
    • The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3
    • Palaparti A., Baratz A., and Stifani S. The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. J Biol Chem 272 (1997) 26604-26610
    • (1997) J Biol Chem , vol.272 , pp. 26604-26610
    • Palaparti, A.1    Baratz, A.2    Stifani, S.3
  • 15
    • 0031785159 scopus 로고    scopus 로고
    • A role for Groucho tetramerization in transcriptional repression
    • Chen G., Nguyen P.H., and Courey A.J. A role for Groucho tetramerization in transcriptional repression. Mol Cell Biol 18 (1998) 7259-7268
    • (1998) Mol Cell Biol , vol.18 , pp. 7259-7268
    • Chen, G.1    Nguyen, P.H.2    Courey, A.J.3
  • 16
    • 0033200392 scopus 로고    scopus 로고
    • A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development
    • Chen G., Fernandez J., Mische S., and Courey A.J. A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev 13 (1999) 2218-2230
    • (1999) Genes Dev , vol.13 , pp. 2218-2230
    • Chen, G.1    Fernandez, J.2    Mische, S.3    Courey, A.J.4
  • 17
    • 0000782017 scopus 로고    scopus 로고
    • The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription
    • Choi C.Y., Kim Y.H., Kwon H.J., and Kim Y. The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription. J Biol Chem 274 (1999) 33194-33197
    • (1999) J Biol Chem , vol.274 , pp. 33194-33197
    • Choi, C.Y.1    Kim, Y.H.2    Kwon, H.J.3    Kim, Y.4
  • 18
    • 0034967002 scopus 로고    scopus 로고
    • Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex
    • Yochum G.S., and Ayer D.E. Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. Mol Cell Biol 21 (2001) 4110-4118
    • (2001) Mol Cell Biol , vol.21 , pp. 4110-4118
    • Yochum, G.S.1    Ayer, D.E.2
  • 19
    • 2942559260 scopus 로고    scopus 로고
    • Groucho oligomerization is required for repression in vivo
    • Song H., Hasson P., Paroush Z., and Courey A.J. Groucho oligomerization is required for repression in vivo. Mol Cell Biol 24 (2004) 4341-4350
    • (2004) Mol Cell Biol , vol.24 , pp. 4341-4350
    • Song, H.1    Hasson, P.2    Paroush, Z.3    Courey, A.J.4
  • 20
    • 35349013604 scopus 로고    scopus 로고
    • Repression by Groucho/TLE/Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo
    • Sekiya T., and Zaret K.S. Repression by Groucho/TLE/Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo. Mol Cell 28 (2007) 291-303
    • (2007) Mol Cell , vol.28 , pp. 291-303
    • Sekiya, T.1    Zaret, K.S.2
  • 21
    • 42149135457 scopus 로고    scopus 로고
    • Spreading of a corepressor linked to action of long range repressor Hairy
    • The authors use chromatin immunoprecipitation experiments to analyse Hairy-dependent, Gro-mediated repression in the Drosophila embryo. They show that Gro does not function by displacing activators and/or coactivators off promoter regions. Instead, recruitment of Gro by Hairy leads to the spreading of Gro and histone deacetylation along an extended region of DNA, explaining the ability of Hairy to exert repression at long range.
    • Martinez C.A., and Arnosti D.N. Spreading of a corepressor linked to action of long range repressor Hairy. Mol Cell Biol 28 (2008) 2792-2802. The authors use chromatin immunoprecipitation experiments to analyse Hairy-dependent, Gro-mediated repression in the Drosophila embryo. They show that Gro does not function by displacing activators and/or coactivators off promoter regions. Instead, recruitment of Gro by Hairy leads to the spreading of Gro and histone deacetylation along an extended region of DNA, explaining the ability of Hairy to exert repression at long range.
    • (2008) Mol Cell Biol , vol.28 , pp. 2792-2802
    • Martinez, C.A.1    Arnosti, D.N.2
  • 22
    • 34547128888 scopus 로고    scopus 로고
    • The 'Marx' of Groucho on development and disease
    • Buscarlet M., and Stifani S. The 'Marx' of Groucho on development and disease. Trends Cell Biol 17 (2007) 353-361
    • (2007) Trends Cell Biol , vol.17 , pp. 353-361
    • Buscarlet, M.1    Stifani, S.2
  • 23
    • 77951454833 scopus 로고    scopus 로고
    • The Groucho/TLE/Grg family of transcriptional co-repressors
    • Jennings B.H., and Ish-Horowicz D. The Groucho/TLE/Grg family of transcriptional co-repressors. Genome Biol 9 (2008) 205
    • (2008) Genome Biol , vol.9 , pp. 205
    • Jennings, B.H.1    Ish-Horowicz, D.2
  • 24
    • 0035937415 scopus 로고    scopus 로고
    • Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
    • Muhr J., Andersson E., Persson M., Jessell T.M., and Ericson J. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell 104 (2001) 861-873
    • (2001) Cell , vol.104 , pp. 861-873
    • Muhr, J.1    Andersson, E.2    Persson, M.3    Jessell, T.M.4    Ericson, J.5
  • 25
    • 0032241789 scopus 로고    scopus 로고
    • Notch signalling in Drosophila: three ways to use a pathway
    • Bray S. Notch signalling in Drosophila: three ways to use a pathway. Semin Cell Dev Biol 9 (1998) 591-597
    • (1998) Semin Cell Dev Biol , vol.9 , pp. 591-597
    • Bray, S.1
  • 26
    • 0032242705 scopus 로고    scopus 로고
    • Notch signalling and the control of cell fate choices in vertebrates
    • Lewis J. Notch signalling and the control of cell fate choices in vertebrates. Semin Cell Dev Biol 9 (1998) 583-589
    • (1998) Semin Cell Dev Biol , vol.9 , pp. 583-589
    • Lewis, J.1
  • 27
    • 0025130594 scopus 로고
    • Notch and the choice of cell fate in Drosophila neuroepithelium
    • Simpson P. Notch and the choice of cell fate in Drosophila neuroepithelium. Trends Genet 6 (1990) 343-345
    • (1990) Trends Genet , vol.6 , pp. 343-345
    • Simpson, P.1
  • 28
    • 0001480152 scopus 로고
    • The molecular genetics of enhancer of split, a gene required for embryonic neural development in Drosophila
    • Preiss A., Hartley D.A., and Artavanis-Tsakonas S. The molecular genetics of enhancer of split, a gene required for embryonic neural development in Drosophila. EMBO J 7 (1988) 3917-3927
    • (1988) EMBO J , vol.7 , pp. 3917-3927
    • Preiss, A.1    Hartley, D.A.2    Artavanis-Tsakonas, S.3
  • 30
    • 32944471841 scopus 로고    scopus 로고
    • Grg1 acts as a lung-specific oncogene in a transgenic mouse model
    • This paper provides compelling evidence supporting an oncogenic role for Gro/TLE in cancer. It reports that transgenic mice overexpressing Gro/TLE develop lung tumours that are associated with reduction in p53 protein levels and upregulation of the ErbB1 and ErbB2 receptor tyrosine kinases. Strikingly, tumour progression in these mice phenocopies molecular and biological features observed in human lung cancer.
    • Allen T., van Tuyl M., Iyengar P., Jothy S., Post M., Tsao M.S., and Lobe C.G. Grg1 acts as a lung-specific oncogene in a transgenic mouse model. Cancer Res 66 (2006) 1294-1301. This paper provides compelling evidence supporting an oncogenic role for Gro/TLE in cancer. It reports that transgenic mice overexpressing Gro/TLE develop lung tumours that are associated with reduction in p53 protein levels and upregulation of the ErbB1 and ErbB2 receptor tyrosine kinases. Strikingly, tumour progression in these mice phenocopies molecular and biological features observed in human lung cancer.
    • (2006) Cancer Res , vol.66 , pp. 1294-1301
    • Allen, T.1    van Tuyl, M.2    Iyengar, P.3    Jothy, S.4    Post, M.5    Tsao, M.S.6    Lobe, C.G.7
  • 31
    • 27944445286 scopus 로고    scopus 로고
    • Hairless-mediated repression of Notch target genes requires the combined activity of Groucho and CtBP corepressors
    • Nagel A.C., Krejci A., Tenin G., Bravo-Patino A., Bray S., Maier D., and Preiss A. Hairless-mediated repression of Notch target genes requires the combined activity of Groucho and CtBP corepressors. Mol Cell Biol 25 (2005) 10433-10441
    • (2005) Mol Cell Biol , vol.25 , pp. 10433-10441
    • Nagel, A.C.1    Krejci, A.2    Tenin, G.3    Bravo-Patino, A.4    Bray, S.5    Maier, D.6    Preiss, A.7
  • 32
    • 0036682974 scopus 로고    scopus 로고
    • Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
    • Barolo S., Stone T., Bang A.G., and Posakony J.W. Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev 16 (2002) 1964-1976
    • (2002) Genes Dev , vol.16 , pp. 1964-1976
    • Barolo, S.1    Stone, T.2    Bang, A.G.3    Posakony, J.W.4
  • 33
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 127 (2006) 469-480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 34
    • 0037093507 scopus 로고    scopus 로고
    • Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling
    • Barolo S., and Posakony J.W. Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev 16 (2002) 1167-1181
    • (2002) Genes Dev , vol.16 , pp. 1167-1181
    • Barolo, S.1    Posakony, J.W.2
  • 35
    • 0032830931 scopus 로고    scopus 로고
    • TCF transcription factors: molecular switches in carcinogenesis
    • Roose J., and Clevers H. TCF transcription factors: molecular switches in carcinogenesis. Biochim Biophys Acta 1424 (1999) M23-37
    • (1999) Biochim Biophys Acta , vol.1424
    • Roose, J.1    Clevers, H.2
  • 37
    • 18744400798 scopus 로고    scopus 로고
    • Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
    • Daniels D.L., and Weis W.I. Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol 12 (2005) 364-371
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 364-371
    • Daniels, D.L.1    Weis, W.I.2
  • 38
    • 42149130936 scopus 로고    scopus 로고
    • Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis
    • Using antibodies that specifically recognise the phosphorylated form of Gro, this paper demonstrates that signalling by multiple receptor tyrosine kinases leads to modification and downregulation of the Gro corepressor during embryonic Drosophila development. Importantly, the authors further show that Gro is phosphorylated by an efficient mechanism and that modification of Gro endures long after MAPK activation has terminated.
    • Cinnamon E., Helman A., Ben-Haroush Schyr R., Orian A., Jimenez G., and Paroush Z. Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis. Development 135 (2008) 829-837. Using antibodies that specifically recognise the phosphorylated form of Gro, this paper demonstrates that signalling by multiple receptor tyrosine kinases leads to modification and downregulation of the Gro corepressor during embryonic Drosophila development. Importantly, the authors further show that Gro is phosphorylated by an efficient mechanism and that modification of Gro endures long after MAPK activation has terminated.
    • (2008) Development , vol.135 , pp. 829-837
    • Cinnamon, E.1    Helman, A.2    Ben-Haroush Schyr, R.3    Orian, A.4    Jimenez, G.5    Paroush, Z.6
  • 40
    • 33645325642 scopus 로고    scopus 로고
    • Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE
    • Hasson P., and Paroush Z. Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE. Br J Cancer 94 (2006) 771-775
    • (2006) Br J Cancer , vol.94 , pp. 771-775
    • Hasson, P.1    Paroush, Z.2
  • 41
    • 35648966585 scopus 로고    scopus 로고
    • A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development
    • Genome-wide DamID profiling uncovers a novel link between Gro/TLE and the Myc oncogene. Specifically, this work shows that Gro physically binds Myc, forming a repressor complex that blocks expression of a subset of Myc target genes involved in neuroblast fate and mitosis. It further establishes that Myc and Gro are essential components of the transcriptional machinery that integrates EGFR and Notch signalling inputs during neurogenesis.
    • Orian A., Delrow J.J., Rosales Nieves A.E., Abed M., Metzger D., Paroush Z., Eisenman R.N., and Parkhurst S.M. A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development. Proc Natl Acad Sci U S A 104 (2007) 15771-15776. Genome-wide DamID profiling uncovers a novel link between Gro/TLE and the Myc oncogene. Specifically, this work shows that Gro physically binds Myc, forming a repressor complex that blocks expression of a subset of Myc target genes involved in neuroblast fate and mitosis. It further establishes that Myc and Gro are essential components of the transcriptional machinery that integrates EGFR and Notch signalling inputs during neurogenesis.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15771-15776
    • Orian, A.1    Delrow, J.J.2    Rosales Nieves, A.E.3    Abed, M.4    Metzger, D.5    Paroush, Z.6    Eisenman, R.N.7    Parkhurst, S.M.8
  • 42
    • 23944506654 scopus 로고    scopus 로고
    • The love-hate relationship between Ras and Notch
    • Sundaram M.V. The love-hate relationship between Ras and Notch. Genes Dev 19 (2005) 1825-1839
    • (2005) Genes Dev , vol.19 , pp. 1825-1839
    • Sundaram, M.V.1
  • 43
    • 33750869046 scopus 로고    scopus 로고
    • Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk
    • Doroquez D.B., and Rebay I. Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk. Crit Rev Biochem Mol Biol 41 (2006) 339-385
    • (2006) Crit Rev Biochem Mol Biol , vol.41 , pp. 339-385
    • Doroquez, D.B.1    Rebay, I.2
  • 44
    • 0037185001 scopus 로고    scopus 로고
    • A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression
    • Nuthall H.N., Joachim K., Palaparti A., and Stifani S. A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression. J Biol Chem 277 (2002) 51049-51057
    • (2002) J Biol Chem , vol.277 , pp. 51049-51057
    • Nuthall, H.N.1    Joachim, K.2    Palaparti, A.3    Stifani, S.4
  • 45
    • 4544297582 scopus 로고    scopus 로고
    • Phosphorylation of serine 239 of Groucho/TLE1 by protein kinase CK2 is important for inhibition of neuronal differentiation
    • Nuthall H.N., Joachim K., and Stifani S. Phosphorylation of serine 239 of Groucho/TLE1 by protein kinase CK2 is important for inhibition of neuronal differentiation. Mol Cell Biol 24 (2004) 8395-8407
    • (2004) Mol Cell Biol , vol.24 , pp. 8395-8407
    • Nuthall, H.N.1    Joachim, K.2    Stifani, S.3
  • 47
    • 10944253639 scopus 로고    scopus 로고
    • Activating the PARP-1 sensor component of the Groucho/TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway
    • Ju B.G., Solum D., Song E.J., Lee K.J., Rose D.W., Glass C.K., and Rosenfeld M.G. Activating the PARP-1 sensor component of the Groucho/TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway. Cell 119 (2004) 815-829
    • (2004) Cell , vol.119 , pp. 815-829
    • Ju, B.G.1    Solum, D.2    Song, E.J.3    Lee, K.J.4    Rose, D.W.5    Glass, C.K.6    Rosenfeld, M.G.7
  • 48
    • 0035887270 scopus 로고    scopus 로고
    • Brinker requires two corepressors for maximal and versatile repression in Dpp signalling
    • Hasson P., Muller B., Basler K., and Paroush Z. Brinker requires two corepressors for maximal and versatile repression in Dpp signalling. EMBO J 20 (2001) 5725-5736
    • (2001) EMBO J , vol.20 , pp. 5725-5736
    • Hasson, P.1    Muller, B.2    Basler, K.3    Paroush, Z.4
  • 49
    • 0034994013 scopus 로고    scopus 로고
    • Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries
    • Kobayashi M., Goldstein R.E., Fujioka M., Paroush Z., and Jaynes J.B. Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries. Development 128 (2001) 1805-1815
    • (2001) Development , vol.128 , pp. 1805-1815
    • Kobayashi, M.1    Goldstein, R.E.2    Fujioka, M.3    Paroush, Z.4    Jaynes, J.B.5
  • 51
    • 0031795513 scopus 로고    scopus 로고
    • Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer
    • Valentine S.A., Chen G., Shandala T., Fernandez J., Mische S., Saint R., and Courey A.J. Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer. Mol Cell Biol 18 (1998) 6584-6594
    • (1998) Mol Cell Biol , vol.18 , pp. 6584-6594
    • Valentine, S.A.1    Chen, G.2    Shandala, T.3    Fernandez, J.4    Mische, S.5    Saint, R.6    Courey, A.J.7
  • 52
    • 0037381625 scopus 로고    scopus 로고
    • In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein
    • Canon J., and Banerjee U. In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein. Genes Dev 17 (2003) 838-843
    • (2003) Genes Dev , vol.17 , pp. 838-843
    • Canon, J.1    Banerjee, U.2
  • 53
    • 33845881156 scopus 로고    scopus 로고
    • Uncoupling Dorsal-mediated activation from Dorsal-mediated repression in the Drosophila embryo
    • Ratnaparkhi G.S., Jia S., and Courey A.J. Uncoupling Dorsal-mediated activation from Dorsal-mediated repression in the Drosophila embryo. Development 133 (2006) 4409-4414
    • (2006) Development , vol.133 , pp. 4409-4414
    • Ratnaparkhi, G.S.1    Jia, S.2    Courey, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.