메뉴 건너뛰기




Volumn 3, Issue 1, 2012, Pages 39-47

Interactions between PPAR-α and inflammation-related cytokine genes on the development of Alzheimer's disease, observed by the Epistasis project

(24)  Heun, Reinhard a,b   Kölsch, Heike a   Ibrahim Verbaas, Carla A c   Combarros, Onofre d   Aulchenko, Yurii S c   Breteler, Monique c   Schuur, Maaike c   van Duijn, Cornelia M c   Hammond, Naomi e   Belbin, Olivia f   Cortina Borja, Mario g   Wilcock, Gordon K h   Brown, Kristelle i   Barber, Rachel i   Kehoe, Patrick G j   Coto, Eliecer j   Alvarez, Victoria k   Lehmann, Michael G e   Deloukas, Panos d   Mateo, Ignacio f   more..


Author keywords

AD; Epistasis; Genetic interaction; Genetics; Inflammation; Interleukin; PPAR alpha; Sporadic; Steroid receptors

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

EID: 84863372774     PISSN: None     EISSN: 19481756     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (26)

References (34)
  • 1
    • 79960880118 scopus 로고    scopus 로고
    • Assessing the Contribution of Inflammation In Models of Alzheimer's Disease
    • Johnston H, Boutin H, Allan SM. Assessing the contribution of inflammation in models of Alzheimer's disease. iochem oc Trans. 2011;39:886-90.
    • (2011) Iochem Oc Trans , vol.39 , pp. 886-890
    • Johnston, H.1    Boutin, H.2    Allan, S.M.3
  • 4
    • 42649084052 scopus 로고    scopus 로고
    • The role of interleukin-1 in neuroinflammation and Alzheimer disease: An evolving perspective
    • Shaftel SS, Griffin WS, O'Banion MK. The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J Neuroinflammation. 2008;5:7.
    • (2008) J Neuroinflammation , vol.5 , pp. 7
    • Shaftel, S.S.1    Griffin, W.S.2    O'Banion, M.K.3
  • 5
    • 0007692414 scopus 로고    scopus 로고
    • In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
    • Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ, Griffin WS. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging. 1996;17:761-6.
    • (1996) Neurobiol Aging , vol.17 , pp. 761-766
    • Sheng, J.G.1    Ito, K.2    Skinner, R.D.3    Mrak, R.E.4    Rovnaghi, C.R.5    van Eldik, L.J.6    Griffin, W.S.7
  • 6
    • 1642420308 scopus 로고    scopus 로고
    • Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
    • Quintanilla RA, Orellana DI, González-Billault C, Maccioni RB. Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. Exp Cell Res. 2004;295:245-57.
    • (2004) Exp Cell Res , vol.295 , pp. 245-257
    • Quintanilla, R.A.1    Orellana, D.I.2    González-Billault, C.3    Maccioni, R.B.4
  • 7
    • 0029102676 scopus 로고
    • Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPARgamma) gene: Alternative promoter use and different splicing yield two mPPAR gamma isoforms
    • Zhu Y, Qi C, Korenberg JR, Chen XN, Noya D, Rao MS, Reddy JK (1995) Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPARgamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc Natl Acad Sci USA 92:7921-7925.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7921-7925
    • Zhu, Y.1    Qi, C.2    Korenberg, J.R.3    Chen, X.N.4    Noya, D.5    Rao, M.S.6    Reddy, J.K.7
  • 8
    • 0034678088 scopus 로고    scopus 로고
    • Peroxisome proliferator-acti-vated receptors: Insight into multiple cellular functions
    • Escher P, Wahli W. Peroxisome proliferator-acti-vated receptors: insight into multiple cellular functions. Mutat Res. 2000;448:121-38.
    • (2000) Mutat Res , vol.448 , pp. 121-138
    • Escher, P.1    Wahli, W.2
  • 9
    • 0034713444 scopus 로고    scopus 로고
    • Roles of PPARs in health and disease
    • Kersten S, Desvergne B, Wahli W. Roles of PPARs in health and disease. Nature. 2000;405:421-4.
    • (2000) Nature , vol.405 , pp. 421-424
    • Kersten, S.1    Desvergne, B.2    Wahli, W.3
  • 10
    • 33746238205 scopus 로고    scopus 로고
    • Molecular indices of oxidative stress and mitochondrial dysfunc-Int. J Mol Epidemiol Tion Occur Early and Often Progress With SeverIty of Alzheimer's Disease
    • De la Monte SM, Wands JR. Molecular indices of oxidative stress and mitochondrial dysfunc-Int J Mol Epidemiol tion occur early and often progress with severity of Alzheimer's disease. J Alzheimers Dis. 2006;9:167-81.
    • (2006) J Alzheimers Dis , vol.9 , pp. 167-181
    • de la Monte, S.M.1    Wands, J.R.2
  • 11
    • 0034813586 scopus 로고    scopus 로고
    • Regulation of beta-amyloid stimulated proin-flammatory responses by peroxisome proliferator-activated receptor alpha
    • Combs CK, Bates P, Karlo JC, Landreth GE. Regulation of beta-amyloid stimulated proin-flammatory responses by peroxisome prolifera-tor-activated receptor alpha. Neurochem Int. 2001;39:449-57.
    • (2001) Neurochem Int , vol.39 , pp. 449-457
    • Combs, C.K.1    Bates, P.2    Karlo, J.C.3    Landreth, G.E.4
  • 14
    • 0042412157 scopus 로고    scopus 로고
    • Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease
    • Brune S, Kölsch H, Ptok U, Majores M, Schulz A, Schlosser R, Rao ML, Maier W, Heun R. Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease. J Neural Transm. 2003;110:1041-50.
    • (2003) J Neural Transm , vol.110 , pp. 1041-1050
    • Brune, S.1    Kölsch, H.2    Ptok, U.3    Majores, M.4    Schulz, A.5    Schlosser, R.6    Rao, M.L.7    Maier, W.8    Heun, R.9
  • 23
    • 0043231492 scopus 로고    scopus 로고
    • Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study
    • Bagli M, Papassotiropoulos A, Hampel H, Beck-er K, Jessen F, Bürger K, Ptok U, Rao ML, Möller HJ, Maier W, Heun R. Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study. Eur Arch Psychiatry Clin Neurosci. 2003;253:44-8.
    • (2003) Eur Arch Psychiatry Clin Neurosci , vol.253 , pp. 44-48
    • Bagli, M.1    Papassotiropoulos, A.2    Hampel, H.3    Beck-Er, K.4    Jessen, F.5    Bürger, K.6    Ptok, U.7    Rao, M.L.8    Möller, H.J.9    Maier, W.10    Heun, R.11
  • 24
    • 0034616230 scopus 로고    scopus 로고
    • Associa-tion between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's disease risk in a German population
    • Bagli M, Papassotiropoulos A, Knapp M, Jes-sen F, Luise Rao M, Maier W, Heun R. Associa-tion between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's disease risk in a German population. Neurosci Lett. 2000;283:109-12.
    • (2000) Neurosci Lett , vol.283 , pp. 109-112
    • Bagli, M.1    Papassotiropoulos, A.2    Knapp, M.3    Jes-Sen, F.4    Luise, R.M.5    Maier, W.6    Heun, R.7
  • 25
    • 0032914896 scopus 로고    scopus 로고
    • A Genetic Varia-tion of the Inflammatory Cytokine Interleukin-6 Delays the Initial Onset and Reduces the Risk For Sporadic Alzheimer's Disease
    • Papassotiropoulos A, Bagli M, Jessen F, Bayer TA, Maier W, Rao ML, Heun R. A genetic varia-tion of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease.Ann Neurol. 1999;45:666-8.
    • (1999) Ann Neurol , vol.45 , pp. 666-668
    • Papassotiropoulos, A.1    Bagli, M.2    Jessen, F.3    Bayer, T.A.4    Maier, W.5    Rao, M.L.6    Heun, R.7
  • 26
    • 79952814212 scopus 로고    scopus 로고
    • The -1082G/A polymorphism in IL-10 gene is associated with risk of Alzheimer's disease: A meta-analysis
    • Zhang Y, Zhang J, Tian C, Xiao Y, Li X, He C,Huang J, Fan H. The -1082G/A polymorphism in IL-10 gene is associated with risk of Alzheimer's disease: a meta-analysis. J Neurol Sci. 2011;303:133-8.
    • (2011) J Neurol Sci , vol.303 , pp. 133-138
    • Zhang, Y.1    Zhang, J.2    Tian, C.3    Xiao, Y.4    Li, X.5    He, C.6    Huang, J.7    Fan, H.8
  • 27
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM,Crain BJ, Brownlee LM, Vogel FS, Hughes JP,van Belle G, Berg L: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991, 41:479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    van Belle, G.9    Berg, L.10
  • 28
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDSADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDSADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer's disease. Neurology 1984; 34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 32
    • 71049187007 scopus 로고    scopus 로고
    • The synergy factor: A statistic to measure interactions in complex diseases
    • Cortina-Borja M, Smith AD, Combarros O, Lehmann DJ. The synergy factor: a statistic to measure interactions in complex diseases. BMC Res Notes. 2009;2:105.
    • (2009) BMC Res Notes , vol.2 , pp. 105
    • Cortina-Borja, M.1    Smith, A.D.2    Combarros, O.3    Lehmann, D.J.4
  • 33
    • 0029610011 scopus 로고
    • The inflammatory re-sponse system of brain: Implications for thera-py of Alzheimer and other neurodegenerative diseases
    • McGeer PL, McGeer EG. The inflammatory re-sponse system of brain: implications for thera-py of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev. 1995;21:195-218.
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 34
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Al-zheimer's disease: Inhibition of beta-amyloidstimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
    • Combs CK, Johnson DE, Karlo JC, Cannady SB,Landreth GE Inflammatory mechanisms in Al-zheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci. 2000;20:558-67.
    • (2000) J Neurosci , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.