Tooth tissue engineering: Potential and piffalls

Journal of Biomimetics, Biomaterials, and Tissue Engineering

Volumn 12, Issue 1, 2012, Pages 59-81

  Gupta, Sweta ^a   Sharma, Chhavi ^a   Dinda, Amit K ^b   Ray, Amiya K ^a   Mishra, Narayan C ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Biomaterials; Growth factors; Scaffold; Stem cell; Tissue engineering; Tooth

Indexed keywords

CLINICAL USE; CONVENTIONAL METHODS; DENTAL CARIES; DIRECT PULP CAPPING; GROWTH FACTOR; GROWTH FACTORS; KEY ELEMENTS; NUMBER OF PEOPLES; SIDE EFFECT; TOOTH; TOOTH REGENERATION;

BIOMATERIALS; DENTAL PROSTHESES; PEPTIDES; SCAFFOLDS; STEM CELLS; TISSUE; TISSUE ENGINEERING;

SCAFFOLDS (BIOLOGY);

EID: 84863363471     PISSN: 16621018     EISSN: None     Source Type: Journal    
DOI: 10.4028/www.scientific.net/JBBTE.12.59     Document Type: Article

References (108)

1. T. Nakahara, Y. Ide. Tooth regeneration: implications for the use of bioengineered organs in first wave organ replacement, Hum Cell, 2007, 20 (3) 63-7O. (Pubitemid 47084049)
2. P.T Sharpe, C.S Young. Test-tube teeth, Sci Am, 2005, 293(2), 34-41. (Pubitemid 41117800)
3. P.E Petersen, Editor. Continuous improvement of oral health in the 21st century the approach of the WHO Global Oral Health Programme. World Health Organization (2003
4. E. Crubzy, P. Murail, L. Girard, J.P Bemadou. False teeth of the Roman world, Nature, 1998, 391, 29.
5. M. Esposito, J.M Hirsch, U. Lekholm, P. Thomsen. Biological factors contributing to failures of osseointegrated oral implants (II), Etiopathogenesis, Eur J Oral Sci. 1998, 106 (3), 721-64. (Pubitemid 128736235)
6. G.J Christensen. How to kill a tooth, J Am Dent Assoc. 2005, 136 (12) 1711-13. (Pubitemid 41810034)
7. K.M Galler, R.N D'Souza, J.D Hartgerink. Biomaterials and their potential applications for dental tissue engineering, J. Mater. Chem. 2010, 20, 8730-46.
8. T. Uchida, C. Murakami, N. Dohi, K. Wakida, T. Satoda, O. Takahashi. Synthesis, secretion, degradation, and fate of ameloblastin during the matrix formation stage of the rat incisor as shown by immunocytochemistry and immunochemistry using region-specific antibodies, J Histochem Cytochem. 1997, 45 (10) 1329-4O. (Pubitemid 27402794)
9. W.T Butler, J.C Brunn, C. Qinm, M.D McKee. Extracellular matrix proteins and the dynamics of dentin formation, Connect. Tissue Res. 2002, 43(2-3) 301-7. (Pubitemid 34777940)
10. R.E Walton, M. Torabinejad. Principles and Practice of Endodontics, third ed. W.B. Saunders Company: Philadelphia, Pennsylvania, 2002, 11-3.
11. M.I Cho, P.R Garante. Radioautographic study of [3H] mannose utilization during cementoblast differentiation, formation of acellular cementum and development of periodontal ligament principle fibres, Anat. Rec. 1989, 223(2) 209-22.
12. R.T Cate, Periodontium, in: Oral Histology, Development, Structure, and Function, Edited J.D John, J. Pendill, Mosby Elsevier: St. Louis. Missouri, China (1994), 239.
13. I. Thesleff. Epithelial-mesenchymal signalling regulating tooth morphogenesis, J Cell Sci. 2003, 116 (9) 1647-8. (Pubitemid 36582151)
14. P. Hölttä. Developmental aberrations of permanent teeth after high-dose anticancer therapy in childhood [dissertation], Department of Paediatric and Preventive Dentistry, University of Helsinki, Finland (2005
15. R. Langer, J. P Vacanti. Tissue engineering, Science 1993, 260 (5110) 920-6. (Pubitemid 23209960)
16. A.H.H Yen, P.T Sharpe. Stem cells and tooth tissue engineering, Cell Tissue Res. 2008, 331 (1) 359-72. (Pubitemid 350265485)
17. C.F Ferreira, R.S Magini, P.T Sharpe. Biological tooth replacement and repair, J Oral Rehabil. 2007, 34 (12) 933-9.
18. W. Sonoyama, Y. Liu, D. Fang, T. Yamaza, B.M Seo, C. Zhang. Mesenchymal stem cell- mediated functional tooth regeneration in swine, PLoS One, 2006, 1 e79.
19. M. Taba Jr., Q. Jin, J.V Sugai, W.V Giannobile. Current concepts in periodontal bioengineering, Orthod Craniofac Res. 2005, 8 (4) 292-302.
20. E. Fuchs, J.A Segre. Stem Cells: A New Lease on Life, Cell 2000, 100 (1) 143-15S. (Pubitemid 30046303)
21. O. Trubiani, G. Orsini, S. Caputi, A. Piatelli. Adult mesenchymal stem cells in dental research: a new approach for tissue engineering, ht J Immunopathol Pharmacol. 2006, 19 (3) 451-6O. (Pubitemid 44580518)
22. B. Inanc, Y.M Elcin. Stem Cells in Tooth Tissue Regeneration - Challenges and Limitations, Stem Cell Rev and Rep. 2011, 7 (3) 683-92.
23. C. Gandia, A. Arminan, J.M Garcia-Verdugo, E. Lledó, A. Ruiz, M.D Miflana, J. SanchezTorrijos, R. Payá, V. Mirabet, F. Carbonell-Uberos, M. Llop, J.A Montero, P. Sepülveda. Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction, Stem Cells 2008, 26 (3) 63 8-4S.
24. I.V Nosrat, J. Widenfalk, L. Olson, C.A Nosrat. Dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in vitro, and rescue motoneurons after spinal cord injury, Dev Biol. 2001, 238 (1) 120-32. (Pubitemid 32962556)
25. I. Kerkis, C.E Ambrosio, A. Kerkis, D.S Martins, E. Zucconi, S.A Fonseca, R.M Cabral, C.M Maranduba, T.P Gaiad, A.C Morini, N.M Vieira, M.P Brolio, O.A Sant'Anna, M.A Miglino, M. Zatz. Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or Systemic, J. Transl Med. 2008, 6, 35-37.
26. A. Graziano, R. d'Aquino, G. Laino, G. Papaccio. Dental pulp stem cells: a promising tool for bone regeneration, Stem Cell Rev. 2008, 4 (1) 2 1-6.
27. V. Govindasamy, A.N Abdullah, V.S Ronald, S. Musa, Z.A.C Ab. Aziz, R.B Zain. Inherent Differential Propensity of Dental Pulp Stem Cells Derived from Human Deciduous and Permanent Teeth, J. Endodontics 2010, 36 (9) 1504-1S.
28. W. Zhang, X.F Walboomers, S. Shi, M. Fan, J.A Jansen. Multilineage differentiation potential of stem cells derived from human dental pulp after cryopreservation, Tissue Eng. 2006, 12 (10) 2813-23. (Pubitemid 46141249)
29. M. Miura, S. Gronthos, M. Zhao, B. Lu, L.W Fisher, P.G Robey, S. Shi. SHED: Stem cells from human exfoliated deciduous teeth, PNAS USA 2003, 100 (10) 5807-5812. (Pubitemid 36576889)
30. S. Abe, S. Yamaguchi, T. Amagasa. Multilineage cells from apical pulp of human tooth with immature apex, Oral Science hit. 2007, 4 (1) 45-58.
31. J. Xu, W. Wang, Y. Kapila, J. Lotz, S. Kapila. Multiple differentiation capacity of STRO1+/CD 146+ PDL mesenchymal progenitor cells, Stem Cells Dev. 2009, 18 (3) 487-96.
32. B. Inanc, A.E Elcin, Y.M Elcin. Osteogenic induction of human periodontal ligament fibroblasts under two-And three-dimensional culture conditions, Tissue Eng. 2006, 12 (2) 257-66.
33. J. Yu, Y. Wang, Z. Deng, L. Tang, Y. Li, J. Shi, Y. Jin. Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells, Biol. Cell 2007, 99 (8) 465-74. (Pubitemid 47272229)
34. G.T Huang, S. Gronthos, S. Shi. Mesenchymal stem cells derived from dental tissues vs those from other sources: their biology and role in regenerative medicine, Journal of Dental Research 2009, 88 (9) 792-806.
35. M.E Yalvac, M. Ramazanoglu, A.A Rizvanov, F. Sahin, O. Bayrak, U. Salli, A. Palotás, G.T Kose. Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascularization, osteo-, adipo- and neurogenesis, The Pharmacogenomics Journal 2010, 10 (2) 105-13.
36. Y. Oda, Y. Yoshimura, H. Ohnishi, M. Tadokoro, Y. Katsube, M. Sasao, Y. Kubo, K. Hattori, S. Saito, K. Horimoto, S. Yuba, H. Ohgushi. Induction of Pluripotent Stem Cells from Human Third Molar Mesenchymal Stromal Cells, The Journal of Biological Chemistry 2010, 285 (38) 29270-8.
37. M.P Lutolf, J.A Hubbell. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering, Nat. Biotechnol. 2005, 23 (1) 47-5S. (Pubitemid 41724624)
38. D.H Kempen, L. Lu, C. Kim, X. Zhu, W.J Dhert, B.L Currier, M.J Yaszemski. Controlled drug release from a novel injectable biodegradable microsphere/scaffold composite based on poly(propylene fumarate), J. Biomed Mater Res A 2006, 77 (1) 103-11.
39. T. Jiang, W.I Abdel-Fattah, C.T Laurencin. In vitro evaluation of chitosan/poly (lactic acidglycolic acid) sintered microsphere scaffolds for bone tissue engineering, Biomaterials 2006, 27 (28) 4894-4903. (Pubitemid 43866923)
40. F. Decup, N. Six, B. Palmier, D. Buch, J.J Lasfargues, E. Salih, M. Goldberg. Bone sialoprotein-induced reparative dentinogenesis in the pulp of rat's molar, Clin Oral Investig. 2000, 4 (2) 110-9.
41. T. Ohara, T. Itaya, K. Usami, Y. Ando, H. Sakurai, M.J Honda, M. Ueda, H. Kagami. Evaluation of scaffold materials for tooth tissue engineering, J Biomed Mater Res A 2010, 94 (3) 800-S.
42. H.C Arca, S. Senel. Chitosan Based Systems for Tissue Engineering, J. Pharm. Sci. 2008, 33, 35-49.
43. W.P Xu, W. Zhang, R. Asrican, H.J Kim, D.L Kaplan, P.C Yelick. Accurately shaped tooth bud cell-derived mineralized tissue formation on silk scaffolds, Tissue Eng Part A 2008, 14 (4) 549-57. (Pubitemid 351520466)
44. A. Gandhi, N. Kathuria, T. Gandhi, A. Arya. Microscale Technologies for Tooth Tissue Engineering and Regenerative Endodontics, Internet Journal of Bioengineering 2011, 4 (2
45. G. Bogen, J.S Kim, L.F Bakland. Direct Pup capping with Mineral Trioxide aggregate, J Am Dent Assoc. 2008, 139 (3) 305-31S.
46. K.A Athanasiou, G.G Niederauer, C.M Agrawal. Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers, Biomaterials 1996, 17 (2) 93-102. (Pubitemid 26031365)
47. C.S Young, H. Abukawa, R. Asrican, M. Ravens, M.J Troulis, L.B Kaban, J.P Vacanti, P.C Yelic. Tissue-engineered hybrid tooth and bone Tissue Eng, 11(2005)1599-161O. (Pubitemid 41636444)
48. A. Vallés-Lluch, E. Novella-Maestre, M. Sancho-Tello, M.M Pradas, G.G Ferrer, C.C Batalla. Mimicking natural dentin using bioactive nanohybrid scaffolds for dentinal tissue engineering, Tissue Engineering - Part A, 16 (2010) 2783-2793.
49. S. Shi, P.M Bartold, M. Miura, B.M Seo, P.G Robey, S. Gronthos. The efficacy of mesenchymal stem cells to regenerate and repair dental structures, Orthod Craniofacial Res., 8 (2005) 191-199.
50. F.M Chen, Y.M Zhao, R. Zhang, T. Jin, H.H Sun, Z.F Wu, Y. Jin. Periodontal regeneration using novel glycidyl methacrylated dextran (Dex-GMA)/gelatin scaffolds containing microspheres loaded with bone morphogenetic proteins, Journal of Controlled Release, 121 (2007) 81-9O. (Pubitemid 47126066)
51. T.F Kuo, H.C Lin, A.T Hung, K.C Yang, H.F Lin, T.K Tanng, S.T Chen, A.H.J Wang. Gelatin-chondroitin-hyaluronan tri-copolymer scaffold seeded with dental bud cells for odontogenesis: An ex vivo study on nude mice, Biomedical Engineering - Applications, Basis and Communications, 22 (2010) 53 5-547.
52. X. Yang, F. Yang, X.F Walboomers, Z. Bian, M. Fan, J.A Jansen. The performance of dental pulp stem cells on nanofibrous PCL/gelatinlnFlA scaffolds, Journal of Biomedical Research, Part A. 93 (2010) 247-257.
53. K. Dobie, G. Smith, A.J Sloan, A.J Smith. Effects of alginate hydrogels and TGF-f31 on human dental pulp repair in vitro, Connective Tissue Research, 43 (2002) 3 87-39O.
54. A.J Sloan, R.B Rutherford, A.J Smith. Stimulation of the rat dentine-pulp complex by bone morphogenetic protein-7 in vitro, Archives of Oral Biology, 45 (2000) 173-177. (Pubitemid 30097341)
55. S. Yokose, H. Kadokura, N. Tajima, A. Hasegawa, H. Sakagami, K. Fujieda, T. Katayama. Platelet-derived growth factor exerts disparate effects on odontoblast differentiation depending on the dimers in rat dental pulp cells, Cell and Tissue Research, 315 (2004) 375-384. (Pubitemid 38657416)
56. H. Lovschall, O. Fejerskov, A. Flybjerg. Pulp-capping with recombinant human insulin-like growth factor I (rhIGF-I) in rat molars, Advances in Dental Research, 15 (2001) 108-112.
57. J. Jernvall, I. Thesleff. Reiterative signalling and patterning during mammalian tooth morphogenesis, Mech Dev., 92 (2000) 19-29. (Pubitemid 30125959)
58. H. Peters, R. Balling. Teeth: where and how to make them, Trends Genet., 15 (1999) 59-6S.
59. T. Mitsiadis, H. Magloire. Epidermal growth factor in tooth development, Actual Odontostomatol., 44 (1990) 257-7O.
60. K. Takahashi, A. Yamane, P. Bringas, J. Caton, H.C Slavkin, M. Zeichner-David. Induction of amelogenin and ameloblastin by insulin and insulin-like growth factors (IGF-I and IGFII) during embryonic mouse tooth development in vitro, Connect Tissue Res., 38 (1998) 269-78. (Pubitemid 29059952)
61. Y. Chai, P. Jr Bringas, A. Mogharei, C.F Shuler, H.C Slavkin. PDGF-A and PDGFR-Alpha regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro, DevDyn., 213 (1998) 500-511. (Pubitemid 28546128)
62. H. Tian, T. Tenzen, A.P McMahon. Dose dependency of Displand genetic interaction between Disp 1 and other hedgehog signalling components in the mouse, Development, 131 (2004) 4021-4033. (Pubitemid 39232161)
63. J.K Sethi, A. Vidal-Puig. Wnt signalling and the control of cellular metabolism, Biochem. J., 427 (2010) 1-17.
64. S. Gestrelius, S.P Lyngstadaas, L. Hammarström. Emdogain - periodontal regeneration based on biomimicry, Clin Oral Invest., 4 (2000) 120-12S.
65. W.M Philbrick, B.E Dreyer, l.A Nakchbandi, A.C Karaplis. Parathyroid hormone-related protein is required for tooth eruption, PNAS, 95 (1998) 11846-11851. (Pubitemid 28460502)
66. T.L. Rodriguez, K.J Nagatomo, B.L Foster, F.H Nociti, M.J Somerman. Modulation of Phosphate/Pyrophosphate Metabolism to Regenerate the Periodontium. A Novel In Vivo Approach, J Periodontol. (2011). Epub.
67. S.A Hacking, A. Khademhosseini. Applications of Microscale technologies for regenerative dentistry, J Dent Res., 88 (2009) 409-421.
68. T. Nakahara, T. Nakamura, E. Kobayashi, K. Kuremoto, T. Matsuno, Y. Tabata. In situ tissue engineering of periodontal tissues by seeding with periodontal ligament-derived cells, Tissue Eng., 10 (2004) 537-544. (Pubitemid 38580274)
69. Y. Liu, Y. Zheng, G. Ding, D. Fang, C. Zhang, P.M Bartold. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine, Stem Cells, 26 (2008) 1065-1073.
70. E.L Gotlieb, P.E Murray, K.N Namerow, S. Kuttler, F. Garcia-Godoy. An ultrastructural investigation of tissue-engineered pulp constructs implanted within endodontically treated teeth, J Am Dent Assoc., 139 (2008) 457-46S.
71. S. Abe, S. Yamaguchi, A. Watanabe, K. Hamada, T. Amagasa. Hard tissue regeneration capacity of apical pulp derived cells (APDC5) from human tooth with immature apex, Biochem Biophys Res Commun., 371 (2008) 90-93.
72. W.P Xu, W. Zhang, R. Asrican, H.J Kim, D.L Kaplan, P.C Yelick. Accurately shaped tooth bud cell-derived mineralized tissue formation on silk scaffolds, Tissue Eng Part A, 14 (2008) 549-557. (Pubitemid 351520466)
73. M.T Duailibi, S.E Duailibi, C.S Young, J.D Bartlett, J.P Vacanti, P.C Yelick. Bioengineered teeth from cultured rat tooth bud cells, J Dent Res., 83 (2004) 523-528. (Pubitemid 41766079)
74. M.J Honda, Y. Sumita, H. Kagami, M. Ueda. Histological and immuno-histochemical studies of tissue engineered odontogenesis, Arch Histol Cytol., 68 (2005) 89-101. (Pubitemid 41126797)
75. C.S Young, H. Abukawa, R. Asrican, M. Ravens, M.J Troulis, L.B Kaban. Tissue- engineered hybrid tooth and bone, Tissue Eng., 11(2005)1599-161O. (Pubitemid 41636444)
76. K. Nakao, R. Morita, Y. Saji, K. Ishida, Y. Tomita, M. Ogawa. The development of a bioengineered organ germ method, Nat Methods, 4 (2007) 227-23O. (Pubitemid 46358872)
77. J. Yu, Z. Deng, J. Shi, H. Zhai, X. Nie, H. Zhuang. Differentiation of dental pulp stem cells into regular-shaped dentin-pulp complex induced by tooth germ cell conditioned medium, Tissue Eng., 12 (2006) 3097-3 10S. (Pubitemid 44846415)
78. A. Ohazama, S.A. Modino, I. Miletich, P.T. Sharpe. Stem-cell-based tissue engineering of murine teeth, J Dent Res, 83 (2004) 518-522.
79. K. Kim, C.H Lee, B.K Kim, J.J Mao. Anatomically shaped tooth and periodontal regeneration by cell homing, J Dent Res., 89 (2010) 842-847.
80. J.T Schantz, H. Chim, M. Whiteman. Cell Guidance in Tissue Engineering: SDF-1 Mediates Site-Directed Homing of Mesenchymal Stem Cells within Three-Dimensional Polycaprolactone Scaffolds, Tissue Engineering., 13 (2007) 2615-2624.
81. C.H Evans, G.D Palmer, A. Pascher, R. Porter, F.N Kwong, E. Gouze. Facilitated endogenous repair: Making tissue engineering simple, practical, and economical, Tissue Eng., 13 (2007) 1987-1993.
82. F.M Chen, J. Zhang, M. Zhang, Y. An, F. Chen, Z.F Wu. A review on endogenous regenerative technology in periodontal regenerative medicine, Biomaterials, 31(2010) 7892-7927.
83. H.A Zander. Reaction of the pulp to calcium hydroxide, J Dent Res., 18 (1939) 373.
84. S. Glas stone-Hughes. The development of halved tooth germs; a study in experimental morphology, J Anat., 86 (1952) 12-2S.
85. C.S Young, S. Terada, J.P Vacanti, M. Honda, J.D Bartlett, P.C Yelick. Tissue engineering of complex tooth structures on biodegradable polymer scaffolds, J Dent Res., 81(2002) 695-70O.
86. M.T Duailibi, S.E Duailibi, C.S Young, J.D Bartlett, J.P Vacanti, P.C Yelick. Bioengineered teeth from cultured rat tooth bud cells, J Dent Res., 83 (2004) 523-528. (Pubitemid 41766079)
87. Y. Chai, H.C Slavkin. Prospects for tooth regeneration in the 21st century: A perspective, Microsc. Res. Tech., 60 (2003) 469-479.
88. A. Ohazama, S.A Modino, I. Miletich, P.T Sharpe. Stem cell based tissue engineering of murine teeth, J Dent. Res., 83 (2004) 5 18-522.
89. A.H Yen, P.T Sharpe. Regeneration of teeth using stem cell-based tissue engineering, Expert Opin. Biol Ther., 6 (2006) 9-16.
90. S. Gronthos, J. Brahim, W. Li, L.W Fisher, N. Cherman, A. Boyde, P. Den Besten, P.G Robey, S. Shi. Stem cell properties of human dental pulp stem cells, J Dent Res., 81(2002) 53 1-53S.
91. S. Gronthos, M. Mankani, J. Brahim, P.G Robey, S. Shi. Postnatal human dental pulp stem cells (DPSC5) in vitro and in vivo, Proc. Natl. Acad. Sci., 97 (2000) 13625-1363O.
92. B. Hu, F. Unda, S. Bopp-Kuchler, L. Jimenez, X.J Wang, Y. Haikel, S.L Wang, H. Lesot. Bone Marrow Cells can give rise to Ameloblast-like Cells, J. Dent. Res., 85 (2006) 416.
93. N. Hasegawa, H. Kawaguchi, A. Hirachi, K. Takeda, N. Mizuno, M. Nishimura, C. Koike, K. Tsuji, H. tha, Y. Kato, H. Kurihara. Behaviour of transplanted bone marrow-derived mesenchymal stem cells in periodontal defects, J Periodontol., 77 (2006) 1003-1007.
94. M. Honda, Y. Sumita, H. Kagami, I. Asahina, M. Ueda. Enamel-Dentin and DentinCementum complex structure formation in tooth-tissue regeneration, European Cells and Materials, 14 (2007) 6O.
95. T. Yokoi, M. Saito, T. Kiyono, S. Iseki, K. Kosaka, E. Nishida, T. Tsubakimoto, H. Harada, K. Eto, T. Noguchi, T. Teranaka. Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo, Cell Tissue Res., 327 (2007) 301-311.
96. M. Honda. Tissue-engineering of Enamel-Dentin Complex Structures. Proceeding 1780 of 85th General Session of the International Association for Dental Research, (2007) University of Tokyo, Japan.
97. K. Nakao, R. Morita, Y. Saji, K. Ishida, Y. Tomita, M. Ogawa, M. Saitoh, Y. Tomooka, T. Tsuji. The development of a bioengineered organ germ method, Nat Methods, 4 (2007) 227-23O. (Pubitemid 46358872)
98. R.M El-Backly, A.G Massoud, A.M El-Badry, R.A Sherif, M.K Marei. Regeneration of dentine/pulp-like tissue using a dental pulp stem cell/poly(lactic-co-glycolic) acid scaffold construct in New Zealand white rabbits, Aust Endod J, 34 (2008) 52-67.
99. M. Tobita, A.C Uysal, R. Ogawa, H. Hyakusoku, H. Mizuno. Periodontal tissue regeneration with adipose-derived stem cells, Tissue Eng Part A, 14 (2008) 945-953. (Pubitemid 351862215)
100. M. Cordeiro, Z. Dong, T. Kaneko, Z. Zhang, M. Miyazawa, S. Shi, A.J Smith, J.E Nor. Dental Pulp Tissue Engineering with Stem Cells from Exfoliated Deciduous Teeth, Journal of Endodontics, 34 (2008) 962-969.
101. S.E Duailibi, M.T Duailibi, W. Zhang, R. Asrican, J.P Vacanti, P.C Yelick. Bioengineered Dental Tissues Grown in the Rat Jaw, J Dent Res., 87 (2008) 745-75O.
102. W. Zhang, H. Abukawa, M.J Troulis, L.B Kaban, J.P Vacanti, P.C Yelick. Tissue engineered hybrid tooth-bone constructs, Methods, 47 (2009) 122-128.
103. T. Jin, Y. Ito, X. Luan, S. Dangaria, C. Walker, M. Allen, A. Kulkarni, C. Gibson, R. Braatz, X. Liao, T.G.H Diekwisch. Supramolecular compaction through polyproline motif elongation as a mechanism for vertebrate enamel evolution, PLoS Biology, 7 (2009) e1000262.
104. G.T.J Huang, T. Yamaza, L.D Shea, F. Djouad, N.Z Kuhn, R.S Tuan, S. Shi. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model, Tissue Eng Part A,. 16 (2010) 605-61S.
105. T.A Mitsiadis, D. Graf, H. Luder, T. Gridley, G. Bluteau. BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation, Development, 137 (2010) 3025-303S.
106. X. Yan, H. Qin, C. Qu, R. S. Tuan, S. Shi, G.T. Huang. iPS cells reprogrammed from human mesenchymal-like stem/progenitor cells of dental tissue origin, Stem Cells and Development 2010, 19 (4) 469-48O.
107. M. Yan, Y. Yu, G. Zhang, C. Tang, J. Yu. A Journey from Dental Pulp Stem Cells to a Biotooth, Stem Cell Rev and Rep., 2011,7(1)161-171.
108. M. Oshima, M. Mizuno, A. Imamura, M. Ogawa, M. Yasukawa, H. Yamazaki, R. Morita, E. Ikeda, K. Nakao, T. Takano-Yamamoto, S. Kasugai, M. Saito, T. Tsuji. Functional Tooth Regeneration Using a Bioengineered Tooth Unit as a Mature Organ Replacement Regenerative Therapy, PLoS One, 2011, 6 (7) e21531.