RhoA of the Rho family small GTPases is essential for B lymphocyte development

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Zhang, Shuangmin ^a   Zhou, Xuan ^a   Lang, Richard A ^a   Guo, Fukun ^a  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; B LYMPHOCYTE RECEPTOR; LIPOPOLYSACCHARIDE; PROTEIN KINASE B; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; B CELL ACTIVATING FACTOR RECEPTOR; CD19 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA PROTEIN, MOUSE; TNFRSF13C PROTEIN, MOUSE; TNFSF13B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SPLEEN;

MUS;

ANIMALS; ANTIGENS, CD19; B-CELL ACTIVATING FACTOR; B-CELL ACTIVATION FACTOR RECEPTOR; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; HEMATOPOIETIC STEM CELLS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PRECURSOR CELLS, B-LYMPHOID; RECEPTORS, ANTIGEN, B-CELL; RHO GTP-BINDING PROTEINS; SPLEEN;

EID: 84863357525     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033773     Document Type: Article

References (38)

1. LeBien TW, Tedder TF, (2008) B lymphocytes: how they develop and function. Blood 112: 1570-1580.
2. Srivastava B, Lindsley RC, Nikbakht N, Allman D, (2005) Models for peripheral B cell development and homeostasis. Semin Immunol 17: 175-182.
3. Pillai S, Cariappa A, Moran ST, (2005) Marginal Zone B cells. Annu Re. Immunol 23: 161-196.
4. Ollila J, Vihinen M, (2005) B cells. Int J Biochem Cell Biol 37: 518-523.
5. Aelst VL, D'Souza-Schorey C, (1997) Rho GTPases and signaling networks. Genes Dev 11: 2295-2322.
6. Etienne-Manneville S, Hall A, (2002) Rho GTPases in cell biology. Nature 420: 629-635.
7. Nobes CD, Hall A, (1995) Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal Complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81: 53-62.
8. Lin R, Cerione RA, Manor D, (1999) Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation. J Biol Chem 274: 23633-23641.
9. Guo F, Zheng Y, (2004) Involvement of Rho family GTPases in p19Arf or p53 mediated proliferation of primary mouse embryonic fibroblasts. Mol Cell Biol 24: 1426-1438.
10. Zohn IM, Campbell SL, Khosravi-Far R, Rossman KL, Der CJ, (1998) Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene 17: 1415-1438.
11. Olson MF, Shworth A, Hall A, (1995) An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269: 1270-1272.
12. Saci A, Carpenter CL, (2005) RhoA GTPase regulates B cell receptor signaling. Mol Cell 17: 205-214.
13. Caloca MJ, Zugaza JL, Bustelo XR, (2008) Mechanistic analysis of the amplification and diversifycation events induced by Vav proteins in B-lymphocytes. J Biol Chem 283: 36454-36464.
14. Cuesta-Mateos C, López-Giral S, Alfonso-Pérez M, de Soria VG, Loscertales J, et al. (2010) Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia. Exp Hematol 38: 756-764.
15. Walmsley MJ, Ooi SK, Reynolds LF, Smith SH, Ruf S, et al. (2003) Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 302: 459-462.
16. Guo F, Velu CS, Grimes HL, Zheng Y, (2009) Rho GTPase Cdc42 is essential for B lymphocyte development and activation. Blood 114: 2909-2916.
17. Zheng Y, (2001) Dbl family guanine nucleotide exchange factors. Trends Biochem Sci 26: 724-732.
18. Bishop AL, Hall A, (2000) Rho GTPases and their effector proteins. Biochem J 348: 241-255.
19. Guo F, Debidda M, Yang L, Williams DA, Zheng Y, (2006) Genetitic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J Biol Chem 281: 18652-18659.
20. Debreceni B, Gao Y, Guo F, Zhu K, Jia B, et al. (2004) Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant. J Biol Chem 279: 2777-2786.
21. Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, et al. (2011) RhoA is dispensable for skin development, but crucial for contraction and directly migration of keratinocytes. Mol Biol Cell 22: 593-605.
22. Katayama K, Melendez J, Baumann JM, Leslie JR, Chauhan BK, et al. (2011) Loss of RhoA in neural progenitor cells causes disruption of adherens and hyperproliferation. Proc Natl Acad Sci U S A 108: 7607-7612.
23. Melendez J, Stengel K, Zhou X, Chauhan BK, Debidda M, et al. (2011) RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. J Biol Chem 286: 15132-15137.
24. Rickert RC, Rajewsky K, Roes J, (1995) Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376: 352-355.
25. Croker BA, Tarlinton DM, Cluse LA, Tuxen AJ, Light A, et al. (2002) The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. J Immunol 168: 3376-3386.
26. Henderson RB, Grys K, Vehlow A, de Bettignies C, Zachacz A, et al. (2010) A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival. J Exp Med 207: 837-853.
27. Kim CH, Broxmeyer HE, (1999) Chemokines: signal lamps for trafficking of T and B cells for development and effector function. J Leukoc Biol 65: 6-15.
28. Rickert RC, Roes J, Rajewsky K, (1997) B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res 25: 1317-1318.
29. Khan WN, (2009) B cell receptor and BAFF receptor signaling regulation of B cell homeostasis. J Immunol 183: 3561-3567.
30. Anwar KN, Fazal F, Malik AB, Rahman A, (2004) RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65. J Immunol 173: 6965-6972.
31. Haudenschild DR, Chen J, Steklov N, Lotz MK, D'Lima DD, (2009) Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli. Mol Cell Biomech 6: 135-144.
32. Perona R, Montaner S, Saniger L, Sánchez-Pérez I, Bravo R, et al. (1997) Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev 11: 463-475.
33. So T, Lee SW, Croft M, (2006) Tumor necrosis factor/tumor necrosis factor receptor family members that positively regulate immunity. Int J Hematol 83: 1-11.
34. Salzer U, Jennings S, Grimbacher B, (2007) To switch or not to switch-the opposing roles of TACI in terminal B cell differentiation. Eur J Immunol 37: 17-20.
35. Shulga-Morskaya S, Dobles M, Walsh ME, Ng LG, MacKay F, et al. (2004) B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J Immunol 173: 2331-2341.
36. Bossen C, Schneider P, (2006) BAFF, APRIL and their receptors: structure, function and signaling. Semin Immunol 18: 263-275.
37. Badr G, Borhis G, Lefevre EA, Chaoul N, Deshayes F, et al. (2008) BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells. Blood 111: 2744-2754.
38. Rohlmann A, Gotthardt M, Hammer RE, Herz J, (1998) Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J Clin Invest 101: 689-695.