Promiscuous binding of extracellular peptides to cell surface class I MHC protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 12, 2012, Pages 4580-4585

  Eisen, Herman N ^a   Hou, Xun Helen ^a   Shen, Chase ^a   Wang, Kaidi ^a   Tanguturi, Varsha Keelara ^a   Smith, Crysela ^a   Kozyrytska, Katerina ^a   Nambiar, Lakshmi ^a   McKinley, Carol A ^a   Chen, Jianzhu ^a   Cohen, Richard J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXTRACELLULAR PEPTIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; DENDRITIC CELL; DISSOCIATION; ENDOCYTOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMISCUOUS PEPTIDE BINDING; PROTEIN BINDING;

ANIMALS; BINDING SITES; CELL MEMBRANE; ENDOCYTOSIS; GENES, MHC CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; MICE; MODELS, BIOLOGICAL; OVALBUMIN; PEPTIDES; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; T-LYMPHOCYTES;

EID: 84863350387     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1201586109     Document Type: Article

References (39)

1. Hartl FU, Bracher A, Hayer-Hartl M (2011) Molecular chaperones in protein folding and proteostasis. Nature 475:324-332.
2. Rüdiger S, Germeroth L, Schneider-Mergener J, Bukau B (1997) Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J 16:1501-1507. (Pubitemid 27151945)
3. Falk K, Rötzschke O, Stevanović S, Jung G, Rammensee HG (1991) Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290-296. (Pubitemid 21896578)
4. Udaka K, Wiesmüller KH, Kienle S, Jung G, Walden P (1996) Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone. J Immunol 157:670-678. (Pubitemid 26231370)
5. Hogquist KA, et al. (1994) T cell receptor antagonist peptides induce positive selection. Cell 76:17-27. (Pubitemid 24035278)
6. Yewdell JW (2006) Confronting complexity: Real-world immunodominance in antiviral CD8+ T cell responses. Immunity 25:533-543.
7. Heath WR, Carbone FR (2001) Cross-presentation in viral immunity and self-tolerance. Nat Rev Immunol 1:126-134. (Pubitemid 33741966)
8. Clement CC, Rotzschke O, Santambrogio L (2011) The lymph as a pool of self-antigens. Trends Immunol 32:6-11.
9. Mohan JF, et al. (2010) Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes. Nat Immunol 11:350-354.
10. Yewdell JW, Reits E, Neefjes J (2003) Making sense of mass destruction: Quantitating MHC class I antigen presentation. Nat Rev Immunol 3:952-961. (Pubitemid 37521537)
11. Wearsch PA, Cresswell P (2008) The quality control of MHC class I peptide loading. Curr Opin Cell Biol 20:624-631.
12. Su RC, Miller RG (2001) Stability of surface H-2K(b), H-2D(b), and peptide-receptive H-2K(b) on splenocytes. J Immunol 167:4869-4877.
13. Binz AK, Rodriguez RC, Biddison WE, Baker BM (2003) Thermodynamic and kinetic analysis of a peptide-class I MHC interaction highlights the noncovalent nature and conformational dynamics of the class I heterotrimer. Biochemistry 42:4954-4961. (Pubitemid 36532048)
14. Gakamsky DM, Bjorkman PJ, Pecht I (1996) Peptide interaction with a class I major histocompatibility complex-encoded molecule: Allosteric control of the ternary complex stability. Biochemistry 35:14841-14848.
15. Gakamsky DM, et al. (1999) An allosteric mechanism controls antigen presentation by the H-2K(b) complex. Biochemistry 38:12165-12173.
16. Schumacher TN, et al. (1990) Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro. Cell 62:563-567.
17. Fahnestock ML, Tamir I, Narhi L, Bjorkman PJ (1992) Thermal stability comparison of purified empty and peptide-filled forms of a class I MHC molecule. Science 258:1658-1662. (Pubitemid 23012440)
18. Sha WC, et al. (1988) Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335:271-274.
19. Day PM, Yewdell JW, Porgador A, Germain RN, Bennink JR (1997) Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells. Proc Natl Acad Sci USA 94:8064-8069. (Pubitemid 27343777)
20. Brophy SE, Jones LL, Holler PD, Kranz DM (2007) Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity. Mol Immunol 44:2184-2194. (Pubitemid 46097122)
21. Matsumura M, Saito Y, Jackson MR, Song ES, Peterson PA (1992) In vitro peptide binding to soluble empty class I major histocompatibility complex molecules isolated from transfected Drosophila melanogaster cells. J Biol Chem 267:23589-23595. (Pubitemid 23088159)
22. Chen W, Khilko S, Fecondo J, Margulies DH, McCluskey J (1994) Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J Exp Med 180:1471-1483.
23. Hämmerling GJ, Rüsch E, Tada N, Kimura S, Hämmerling U (1982) Localization of allodeterminants on H-2Kb antigens determined with monoclonal antibodies and H-2 mutant mice. Proc Natl Acad Sci USA 79:4737-4741.
24. Zhang LW, Bäumer W, Monteiro-Riviere NA (2011) Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells. Nanomedicine (Lond) 6:777-791.
25. Hoof I, et al. (2009) NetMHCpan, a method for MHC class I binding prediction beyond humans. Immunogenetics 61:1-13.
26. Kosmrlj A, et al. (2010) Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature 465:350-354.
27. Istrail S, et al. (2004) Comparative immunopeptidomics of humans and their pathogens. Proc Natl Acad Sci USA 101:13268-13272. (Pubitemid 39209654)
28. Gutiérrez RA, Green PJ, Keegstra K, Ohlrogge JB (2004) Phylogenetic profiling of the Arabidopsis thaliana proteome: What proteins distinguish plants from other organisms? Genome Biol 5:R53.
29. Sykulev Y, et al. (1994) Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. Immunity 1:15-22.
30. Dutz JP, Tsomides TJ, Kageyama S, Rasmussen MH, Eisen HN (1994) A cytotoxic T lymphocyte clone can recognize the same naturally occurring self peptide in association with a self and nonself class I MHC protein. Mol Immunol 31:967-975.
31. Sykulev Y, et al. (1994) High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc Natl Acad Sci USA 91:11487-11491. (Pubitemid 24356369)
32. Grotenbreg GM, et al. (2007) Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. J Biol Chem 282:21425-21436. (Pubitemid 47099928)
33. Springer S, Doring K, Skipper JC, Townsend AR, Cerundolo V (1998) Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding. Biochemistry 37:3001-3012. (Pubitemid 28145753)
34. Jacob J, Baker B, Bryant RG, Cafiso DS (1999) Distance estimates from paramagnetic enhancements of nuclear relaxation in linear and flexible model peptides. Biophys J 77:1086-1092. (Pubitemid 29362478)
35. Insaidoo FK, et al. (2011) Loss of T cell antigen recognition arising from changes in peptide and major histocompatibility complex protein flexibility: Implications for vaccine design. J Biol Chem 286:40163-40173.
36. Wu C, et al. (2011) Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals. Proc Natl Acad Sci USA 108:9178-9183.
37. Tscharke DC, et al. (2005) Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J Exp Med 201:95-104. (Pubitemid 40130087)
38. Moutaftsi M, et al. (2006) A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nat Biotechnol 24:817-819. (Pubitemid 44086622)
39. Porgador A, Yewdell JW, Deng Y, Bennink JR, Germain RN (1997) Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity 6:715-726. (Pubitemid 27305734)