Distance estimates from paramagnetic enhancements of nuclear relaxation in linear and flexible model peptides

Biophysical Journal

Volumn 77, Issue 2, 1999, Pages 1086-1092

  Jacob, Jaison ^a,b   Baker, Brian ^a,c   Bryant, Robert G ^a   Cafiso, David S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c La Jolla Pharmaceutical Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITROXIDE; PEPTIDE; TRYPTOPHAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SPIN LABELING;

EID: 0032780521     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(99)76958-4     Document Type: Article

References (15)

1. Bloombergen, N., E. M. Purcell, and R. V. Pound. 1948. Relaxation effects in nuclear magnetic resonance absorption. Phys. Rev. 73:679-712.
2. Cavanagh, J., W. J. Fairbrother, A. G. Palmer, and N. J. Skelton. 1996. Protein NMR Spectroscopy: Principles and Practice. Academic Press, Inc., San Diego, CA.
3. Fesik, S. W., G. Gemmecker, E. T. Olejniczak, and A. M. Petros. 1991. Identification of solvent-exposed regions of enzyme-bound ligands by nuclear magnetic resonance. J. Am. Chem. Soc. 113:7080-7081.
4. Hochstrasser, R. A., S. M. Chen, and D. P. Millar. 1992. Distance distribution in a dye-linked oligonuleotide determined by time-resolved fluorescence energy transfer. Biophys. Chem. 45:133-141.
5. Isied, S. S., and A. Vassilian. 1984. Electron transfer across polypeptides. J. Am. Chem. Soc. 106:1726-1736.
6. Krugh, T. R. 1976. Spin-label-induced nuclear magnetic resonance relaxation studies of enzymes. In Spin Labeling, Theory and Applications. Academic Press, New York. 339-372.
7. Lee, Y.-H., B. L. Currie, and M. E. Johnson. 1986. Interaction of spin-labeled phenylalanine analogue with normal and sickle hemoglobins: detection of site-specific interactions through spin-label-induced 1H NMR relaxation. Biochemistry. 25:5647-5654.
8. North, C. L., C. J. Franklin, R. G. Bryant, and D. S. Cafiso. 1994. Molecular flexibility demonstrated by paramagnetic enhancements of nuclear relaxation. Application to alamethicin: a voltage-gated peptide channel. Biophys. J. 67:1861-1866.
9. Rosevear, P. R., D. C. Fry, A. S. Mildvan, M. Doughty, C. O'Brian, and E. T. Kaiser. 1984. NMR studies of the backbone protons and secondary structure of pentapeptide and heptapeptide substrates bound to bovine heart protein kinase. Biochemistry. 23:3161-3173.
10. Schmidt, P. G., and I. D. Kuntz. 1984. Distance measurements in spin-labeled lysozyme. Biochemistry. 23:4261-4266.
11. Solomon, I. 1955. Relaxation processes in a system of two spins. Phys. Rev. 99:559-565.
12. Sternlicht, H., and E. Wheeler. 1967. Preliminary magnetic resonance studies of spin labeled macromolecules. In Magnetic Resonance in Biological Systems. Pergamon, Oxford, U.K. 325-334.
13. Stryer, L. 1978. Fluorescence energy transfer as a spectroscopic ruler. Ann. Rev. Biochem. 47:819-846.
14. Stryer, L., and R. P. Haugland. 1967. Energy transfer: a spectroscopic ruler. Proc. Natl. Acad. Sci. USA. 58:719-726.
15. Stewart, J. M., and J. D. Young. 1984. Solid Phase Peptide Synthesis. Pierce Chemical Co., Rockford, IL.