Novel porous scaffolds of poly(lactic acid) produced by phase-separation using room temperature ionic liquid and the assessments of biocompatibility

Journal of Materials Science: Materials in Medicine

Volumn 23, Issue 5, 2012, Pages 1271-1279

  Lee, Hye Young ^a,b   Jin, Guang Zhen ^a,b   Shin, Ueon Sang ^a,b   Kim, Joong Hyun ^a,b   Kim, Hae Won ^a,b,c  

^a Dankook University   (South Korea)

^b BK21 Plus NBM Global Research Center for Regenerative Medicine   (South Korea)

^c Dankook University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; BIODEGRADABLE POLYMER SCAFFOLDS; BIOLOGICAL PROPERTIES; BONE SIALOPROTEINS; CELL COMPATIBILITY; CELL POPULATIONS; COLLAGEN TYPE I; DRYING PROCESS; IN-VITRO; IN-VIVO; INFLAMMATORY REACTION; MESENCHYMAL STEM CELL; OSTEOBLASTIC DIFFERENTIATION; OSTEOCALCIN; OSTEOGENESIS; OSTEOGENIC; PILOT STUDIES; POLY LACTIC ACID; POLYLACTIC ACIDS; POLYMER PHASE; POLYMER STRUCTURE; PORE NETWORKS; POROGENS; POROUS NETWORKS; POROUS POLYMERS; POROUS SCAFFOLD; RAT BONE MARROW; ROOM TEMPERATURE IONIC LIQUIDS; SELECTIVE DISSOLUTION; TISSUE COMPATIBILITY; TISSUE CULTURE PLASTICS; TISSUE REGENERATION;

BIOCOMPATIBILITY; CELL CULTURE; CELL PROLIFERATION; ETHANOL; GENE EXPRESSION; IONIC LIQUIDS; LACTIC ACID; ORGANIC SOLVENTS; PHOSPHATASES; RATS; THREE DIMENSIONAL; TISSUE;

SCAFFOLDS (BIOLOGY);

ALCOHOL; ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; COLLAGEN TYPE 1; IONIC LIQUID; OSTEOCALCIN; POLYLACTIC ACID; TISSUE SCAFFOLD;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL GROWTH; CELL POPULATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOCOMPATIBILITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MESENCHYMAL STEM CELL; NANOPORE; NONHUMAN; OSTEOBLAST; PARTICLE SIZE; PHASE SEPARATION; PILOT STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ROOM TEMPERATURE; TISSUE CULTURE; TISSUE REGENERATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; IONIC LIQUIDS; LACTIC ACID; MALE; MATERIALS TESTING; MESENCHYMAL STEM CELLS; MODELS, BIOLOGICAL; OSTEOBLASTS; OSTEOGENESIS; PHASE TRANSITION; POLYMERS; POROSITY; RATS; RATS, SPRAGUE-DAWLEY; TEMPERATURE; TISSUE SCAFFOLDS;

RATTUS;

EID: 84863334321     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-012-4588-4     Document Type: Article

References (29)

1. Freymana TM, Yannasb IV, Gibson LJ. Cellular materials as porous scaffolds for tissue engineering. Prog Mater Sci. 2001;46:273-82. (Pubitemid 32264828)
2. Agrawal CM, Ray RB. Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. J Biomed Mater Res. 2001;55:141-50. (Pubitemid 32198496)
3. Hutmacher DW. Polymeric scaffolds in tissue engineering bone and cartilage. Biomaterials. 1998;21:2529-43.
4. Oh CH, Hong SJ, Yu HS, Jegal SH, Kim HW. Development of robotic dispensed bioactive scaffolds and human adipose-derived stem cell culturing for bone tissue engineering. Tissue Eng C. 2010;16:561-71.
5. Hollister SJ. Porous scaffold design for tissue engineering. Nature Mater. 2005;4:518-24. (Pubitemid 40952745)
6. Kim HW, Lee SY, Bae CJ, Noh YJ, Kim HE, Kim HM, Ko JS. Porous ZrO2 scaffold coated with hydroxyapatite with fluorapatite intermediate layer. Biomaterials. 2003;24:3277-84. (Pubitemid 36577676)
7. Hoa MH, Kuoa PY, Hsieha HJ, Hsienb TY, Houc LT, Laid JY, Wang DM. Preparation of porous scaffolds by using freezeextraction and freeze-gelation methods. Biomaterials. 2004;25: 129-38.
8. Kim HW. C, Kim HE. Hydroxyapatite and gelatin composite foams processed via novel freeze-drying and crosslinking for use as temporary hard tissue scaffolds. J Biomed Mater Res A. 2005;72A:136-45.
9. Farrar G, Barone J, Morgan A. Ovalbumin-based porous scaffolds for bone tissue regeneration. J Tissue Eng 2010;2010:6 (Article ID 209860).
10. Hong SJ, Jeong I, Noh KT, Yu HS, Lee KS, Kim HW. Robotic dispensing of composite scaffolds and in vitro responses of bone marrow stromal cells. J Mater Sci Mater Med. 2009;20:1955-62.
11. Kim SH, Oh SA, Lee UK, Shin US, Kim HW. Poly(lactic acid) porous scaffold with calcium phosphate mineralized surface and bone marrow mesenchymal stem cell growth and differentiation. Mater Sci Eng C. 2011;31:611-9.
12. Uebersax L, Hagenmü ller H, Hofmann S, Gruenblatt E, Mü ller R, Vunjaknovakovic G, Kaplan D. L, Merkle H.P., Meinel L. Effect of scaffold design on bone morphology in vitro. Tiss Eng 2006;12:3417-3429. (Pubitemid 46037165)
13. Hutmacher DW, Sittinger M, Risbud MV. Scaffold-based tissue engineering: rationale for computer-aided design and solid freeform fabrication systems. Trends Biotech. 2004;22:354-62. (Pubitemid 38887544)
14. Jun IK, Song JH, Choi WY, Koh YH, Kim HE, Kim HW. Porous hydroxyapatite scaffolds coated with bioactive apatite-wollastonite glass ceramics. J Am Ceram Soc. 2007;90:2703-8.
15. Lee EJ, Koh YH, Yoon BH, Kim HE, Kim HW. Highly porous hydroxyapatite bioceramics with interconnected pore channels using camphene-based freeze casting. Mater Lett. 2007;61: 2270-3.
16. Araki K, Halloran JW. Porous ceramic bodies with interconnected pore channels by a novel freeze casting technique. J Am Ceram Soc. 2005;88:1108-14. (Pubitemid 41557961)
17. Deville S, Saiz E, Nalla RK, Tomsia AP. Freezing as path to build complex composites. Science. 2006;311:515-8. (Pubitemid 43157728)
18. Lee HY, Shin US, Kim HW. Using hydrophilic ionic liquids as a facile route to prepare porous-structured biopolymer scaffolds. Mater Lett. 2011;65:2114-7.
19. Oh SA, Kim SH, Won JE, Kim JJ, Shin US, Kim HW. Effects on growth and osteogenic differentiation of mesenchymal stem cells by the zinc-added sol-gel bioactive glass granules. J Tiss Eng. 2010; 2010:10 (Article ID 475260).
20. Nam SM, Won JE, Kim CH, Kim HW. Odontogenic differentiation of human dental pulp stem cells stimulated by the calcium phosphate porous granules. J Tiss Eng 2010; 2010:10 (Article ID 812547).
21. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 2005;26:5474-91. (Pubitemid 40592136)
22. Huddleston JG, Visser AE, Reichert WM, Willauer HD, Broker GA, Rogers RD. Characterization and comparison of hydrophilic and hydrophobic room temperature ionic liquids incorporating the imidazolium cation. Green Chem. 2001;3:156-64. (Pubitemid 33319370)
23. Welton T. Room-temperature ionic liquids, Solvents for synthesis and catalysis. Chem Rev. 1999;99:2071-83. (Pubitemid 129585179)
24. Wang Y, Liu Z, Han B, Sun Z, Zhang J, Sun D. Phase-separationinduced micropatterned polymer surfaces and their applications. Adv Funct Mater. 2005;15:655-63. (Pubitemid 40519785)
25. Park HS, Yang HS, Jun YS, Hong WH, Kang JK. Facile route to synthesize large-mesoporous c-alumina by room temperature ionic liquids. Chem Mater. 2007;19:535-42.
26. Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell. 2009;5:17-26.
27. Berrier AL, Yamada KM. Cell-matrix adhesion. J Cell Physiol. 2007;213:565-73. (Pubitemid 350058247)
28. Lee JH, Yu HS, Lee GS, Ji A, Hyun JK, Kim HW. Collagen gel three-dimensional matrices combined with adhesive proteins stimulate neuronal differentiation of mesenchymal stem cells. J Roy Soc Interf. 2011;8:998-1010.
29. Jegal SH, Park JH, Kim JH, Kim TH, Shin US, Kim TI, Kim HW. Functional composite nanofibers of poly(lactide-co-caprolactone) containing gelatin-apatite bone mimetic precipitate for bone regeneration. Acta Biomater. 2011;7:1609-17.