Preparation of injectable auto-forming alginate gel containing simvastatin with amorphous calcium phosphate as a controlled release medium and their therapeutic effect in osteoporosis model rat

Journal of Materials Science: Materials in Medicine

Volumn 23, Issue 5, 2012, Pages 1291-1297

  Ito, Tomoko ^a   Saito, Mami ^a   Uchino, Tomohiro ^a,b   Senna, Mamoru ^a,c   Iafisco, Michele ^d,e   Prat, Maria ^d   Rimondini, Lia ^d   Otsuka, Makoto ^a  

^a MUSASHINO UNIVERSITY   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c RIKEN   (Japan)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC CONDITIONS; ALGINATE GEL; ALGINATE SOLUTIONS; AMORPHOUS CALCIUM PHOSPHATE; CONTROLLED RELEASE; CONTROLLING DEVICES; MODEL DRUGS; RELEASE RATE; SIMVASTATIN; THERAPEUTIC EFFECTS;

CALCIUM PHOSPHATE; DRUG DELIVERY; RATS;

DISEASES;

ALGINIC ACID; CALCIUM PHOSPHATE; SIMVASTATIN;

ACIDIFICATION; ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; GEL; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; RAT; ULTRAVIOLET SPECTROSCOPY;

ALGINATES; ANIMALS; BUFFERS; CALCIUM PHOSPHATES; CATALYSIS; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; FEMALE; GELS; HYPOLIPIDEMIC AGENTS; INJECTIONS; OSTEOPOROSIS; POLYMERIZATION; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

RATTUS;

EID: 84863331085     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-012-4597-3     Document Type: Article

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