Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice

Molecular Vision

Volumn 18, Issue , 2012, Pages 1668-1683

  Yu, Hong ^a   Ozdemir, Sacide S ^a   Koilkonda, Rajeshwari D ^a   Chou, Tsung Han ^a   Porciatti, Vittorio ^a   Chiodo, Vince ^b   Boye, Sanford L ^b   Hauswirth, William W ^b   Lewin, Alfred S ^b   Guy, John ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NADH DEHYDROGENASE SUBUNIT 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; DNA SEQUENCE; DNA TRANSCRIPTION; ELECTRORETINOGRAM; EMBRYO; GENE EXPRESSION; GENE TARGETING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; MUTANT; ND4 GENE; NERVE FIBER DEGENERATION; NONHUMAN; OPTIC NERVE ATROPHY; PAPILLEDEMA; PRIORITY JOURNAL; RETINA GANGLION CELL; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; TRANSMISSION ELECTRON MICROSCOPY; VIRAL GENE DELIVERY SYSTEM; VISUAL IMPAIRMENT;

ANIMALS; BLINDNESS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; ELECTRORETINOGRAPHY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; INTRAVITREAL INJECTIONS; MICE; MITOCHONDRIA; NADH DEHYDROGENASE; OPTIC ATROPHY; OPTIC ATROPHY, HEREDITARY, LEBER; OPTIC NERVE; POINT MUTATION; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; RETINAL GANGLION CELLS;

EID: 84863315789     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

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