Animal models of acute tubular necrosis

Current Opinion in Critical Care

Volumn 8, Issue 6, 2002, Pages 526-534

  Heyman, Samuel N ^a,e   Lieberthal, Wilfred ^b   Rogiers, Peter ^d   Bonventre, Joseph V ^c  

^a HEBREW UNIVERSITY   (Israel)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d MIDDELHEIM HOSPITAL   (Belgium)

^e HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE KIDNEY TUBULE NECROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; EVALUATION; FUNCTIONAL ASSESSMENT; GLOMERULUS FILTRATION; HEMODYNAMICS; HISTOPATHOLOGY; IMAGING; INTENSIVE CARE; INTENSIVE CARE UNIT; KIDNEY EPITHELIUM; KIDNEY INJURY; KIDNEY TUBULE NECROSIS; MICROCIRCULATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; RAT; TECHNIQUE;

ANIMALS; DISEASE MODELS, ANIMAL; ISCHEMIA; KIDNEY; KIDNEY TUBULAR NECROSIS, ACUTE; PERFUSION; RATS; SEPSIS;

EID: 0036891710     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075198-200212000-00008     Document Type: Conference Paper

References (41)

1. Bonventre JV, Brezis M, Siegel N, et al.: Acute renal failure. I. Relative importance of proximal vs. distal tubular injury. Am J Physiol 1998, 275: F623-F632.
2. Brezis M, Rosen S: Hypoxia of the renal medulla: Its implications for disease. N Engl J Med 1995, 332:647-655.
3. Heyman SN, Rosen S, Brezis M: The renal medulla: Life at the edge of anoxia. Blood Purif 1997, 15:232-242.
4. Molitoris BA, Weinberg JM, Manjeri A, et al.: Acute renal failure. II. Experimental models of acute renal failure: Imperfect but indispensable. Am J Physiol 2000, 278:F1-F12.
5. Rosen S, Heyman SN: Difficulties in understanding human "acute tubular necrosis": Limited data and flawed animal models. Kidney Int 2001,60:1220-1224. This review complements [1-4,6] and deals with fundamental concepts and unsettled issues regarding the pathophysiology of ATN. It underscores the imperfection of the various animal models of ischemic ATN.
6. Hammerman MR, Safirstein R, Harris RC, et al.: Acute renal failure, III: The role of growth factors in the process of renal regeneration and repair. Am J Physiol 2000, 279:F3-F11.
7. Piper RD, Cook DJ, Bone RC, et al.: Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med 1996, 24:2059-2070.
8. Harvig B, Engbert A, Ericsson JLE: Effects of cold ischemia on the preserved and transplanted rat kidney: Structural changes of the loop of Henle, distal tubule and collecting duct. Virchows Arch B Cell Pathol 1980, 34:173-192.
9. Heyman SN, Brezis M, Rosen S: The isolated perfused rat kidney model in experimental renal injury. In Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals. Edited by Bennett WM, DeBroe ME, Porter GA, et al. Dordrecht: Kluwer; 1998:77-82.
10. Heyman SN, Reichman J, Brezis M: The pathophysiology of contrast nephropathy: A role for medullary hypoxia. Invest Radiol 1999, 34:685-691.
11. Goldfarb M, Abassi Z, Rosen S, et al.: Chronic heart failure predisposes to hypoxic outer medullary tubular injury: Studies in rats. Kidney Int 2001, 60:607-613. This is an example of adopting the multiple insult concept in the design of experimental ATN.
12. Heyman SN, Rosen S, Darmon D, et al.: Endotoxin-induced renal failure. II. A role for tubular hypoxic damage. Exp Nephrol 2000, 8:275-282.
13. Heyman SN, Rosen S, Epstein FH, et al.: Loop diuretics reduce hypoxic damage to proximal tubules of the isolated perfused rat kidney. Kidney Int 1994, 45:981-985.
14. Spiegel DM, Shanley PF, Molitoris BA: Mild ischemia predisposes the S3 segment to gentamicin toxicity. Kidney Int 1990, 38:459-464.
15. Rosen S, Brezis M, Stillman I: The pathology of nephrotoxic injury: A reappraisal. Miner Electrolyte Metab 1994, 20:174-180.
16. Deng J, Kohda Y, Chiao H, et al.: Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury. Kidney Int 2001, 60:2118-2128. This study illustrates the commonly used ischemia-reflow model of ATN and a representative of toxic experimental ATN, underscoring the important pathophysiologic role of inflammation.
17. Shiraishi F, Curtis LM, Truong L, et al.: Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am J Physiol 2000, 278:F726-F736.
18. Zager RA: Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int 1996, 49:314-326.
19. Heyman SN, Rosen S, Fuchs S, et al.: Myoglobinuric acute renal failure in the rat: A role for medullary hypoperfusion, hypoxia and tubular obstruction. J Am Soc Nephrol 1996, 7:1066-1074.
20. Heyman SN, Goldfarb M, Darmon D, et al.: Endotoxin-induced renal failure, I: A role for altered renal microcirculation. Exp Nephrol 2000, 8:266-274.
21. Shultz P J, Raji L: Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis. J Clin Invest 1992, 90:1718-1725.
22. Deitch EA: Animal models of sepsis and septic shock: A review and lessons learned. Shock 1998, 9:1-11.
23. Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shock: A review of laboratory models and a proposal. J Surg Res 1980, 29:189-201.
24. Fink MP, Heard SO: Laboratory models of sepsis and septic shock. J Surg Res 1990, 49:186-199.
25. Heyman SN, Rosen S, Epstein FH, et al.: Loop diuretics reduce hypoxic damage to proximal tubules of the isolated perused rat kidney. Kidney Int 1994, 45:981-985.
26. Olsen TS, Hansen HE: Ultrastructure of medullary tubules in ischemic acute tubular necrosis and acute interstitial nephritis in man. APMIS 1990, 98:1139-1148. This is perhaps the most important latest critical assessment of human ATN, addressing the issue of tubular segments involved.
27. Oliver J, McDowell M, Tracy A: The pathogenesis of acute renal failure associated with traumatic and toxic injury, renal ischemia, nephrotoxic damage and ischemuric episode. J Olin Invest 1951, 30:1307-1351.
28. Heyman SN, Shina A, Brezis M, et al.: Proximal tubular injury attenuates outer medullary hypoxic damage: Studies in the isolated perused kidney. Exp Nephrol 2002, 10:259-266. This work illustrates the isolated perused kidney model and underscores the impact of attenuation of tubular reabsorptive workload on distal tubular injury. It may explain why the distal tubule is relatively resistant to ischemia-reflow.
29. Brezis M, Heyman SN, Epstein F: Determinants of intrarenal oxygenation, II: Hemodynamic effects. Am J Physiol 1994, 267:F1063-F1068.
30. Weinberg JM, Nissim I, Roeser NF, et al.: Relationships between intracellular amino acid levels and protection against injury to isolated proximal tubules. Am J Physiol 1991, 260:F410-F419.
31. Silva P, Rosen S, Spokes K, et al.: Effect of glycine on medullary thick ascending limb injury in perfused kidneys. Kidney Int 1991, 39:653-658.
32. Sun Q, Dimopoulos G, Nguyen N, et al.: Low dose vasopressin in the treatment of septic shock in sheep [abstract]. Intensive Care Med 2001,27(suppl 2):A113.
33. Rogiers P, Sun Q, Pauwels D, et al.: Effects of hemofiltration with high cut-off membrane in ovine septic shock [abstract]. Intensive Care Med 2001, 27(suppl 2):A497.
34. Alcorn D, Emslie K, Ross B, et al.: Selective distal nephron damage and isolated perfused rat kidney. Kidney Int 1981, 19:638-647.
35. Endre ZH, Ratcliffe PJ, Tange JD, et al.: Erythrocytes alter the pattern of renal hypoxic injury: Predominance of proximal tubular injury with moderate hypoxia. Clin Sci (London) 1989, 76:19-29.
36. Lieberthal W, Stephens G, Wolf E, et al.: Effect of erythrocytes on the function and morphology of the isolated perfused kidney. Ren Physiol 1987, 20:14-24.
37. Lieberthal W, Wolf EF, Rennke HG, et al.: Renal ischemia and reperfusion impair endothelium-dependent vascular relaxation. Am J Physiol 1989, 256:F894-F900.
38. Lieberthal W, Vasilevsky M, Valeri C, et al.: Interactions between ADH and prostaglandins in the isolated erythrocyte-perfused kidney. Am J Physiol 1987, 252:F331-F337.
39. Lieberthal W, Rennke HG, Sandock KM, et al.: Ischemia in the isolated erythrocyte-perfused rat kidney: Protective effect of hypothermia. Renal Physiol Biochem 1988, 11:60-69.
40. Endre ZE, Ratcliffe PJ: Patterns of ischemic renal cell injury. In Acute Renal Failure, Edn 1. Edited by Solez K, Racusen L. New York: Marcel Dekker; 1991:173-181.
41. Han WK, Bailly V, Abichandani R, et al.: Kidney injury molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury. Kidney Int 2002, 62:237-244. This work illustrates the potential application of a proximal tubular injury marker identified in experimental ischemia-reflow injury in the detection of human ATN.