Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 22717-22729

  Pitts, Andrea ^a   Dailey, Kyle ^a   Newington, Jordan T ^a   Chien, Andrew ^a   Arseneault, Robert ^a   Cann, Tyler ^a   Thompson, Leslie M ^b   Cumming, Robert C ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3-NITROPROPIONIC ACIDS; CELL MODEL; DIMERCAPTOSUCCINIC ACIDS; DISULFIDE BONDING; DISULFIDE BONDS; ECTOPIC EXPRESSIONS; HUNTINGTIN; HUNTINGTON DISEASE; MASS SPECTROMETRY ANALYSIS; MITOCHONDRIAL DYSFUNCTION; MONOTHIOL; MUTANT HUNTINGTIN; NEURODEGENERATIVE DISORDERS; PC12 CELLS; POLYGLUTAMINE; PROTEIN EXTRACT; REACTIVE OXYGEN SPECIES; REDOX STATE; SELECTIVE OXIDATION; SULFHYDRYL GROUPS;

AMINO ACIDS; CELLS; COVALENT BONDS; CYTOLOGY; MASS SPECTROMETRY; NEURODEGENERATIVE DISEASES; OXYGEN; RNA; TOXICITY;

PROTEINS;

3 NITROPROPIONIC ACID; DIMERCAPROL; DITHIOL DERIVATIVE; HUNTINGTIN; MONOTHIOL DERIVATIVE; PEROXIREDOXIN 1; POLYGLUTAMINE; REACTIVE OXYGEN METABOLITE; RNA; SHORT HAIRPIN RNA; SUCCIMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; DRUG MECHANISM; GENETIC TRANSFECTION; HUNTINGTON CHOREA; IMMUNOBLOTTING; MASS SPECTROMETRY; MOUSE; MUTANT; NONHUMAN; OXIDATION REDUCTION REACTION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; RODENT;

ANIMALS; CELL DEATH; CELL LINE, TRANSFORMED; CORPUS STRIATUM; DISULFIDES; HUNTINGTON DISEASE; MITOCHONDRIA; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; NUCLEAR PROTEINS; OXIDATIVE STRESS; PC12 CELLS; PEPTIDES; PEROXIREDOXINS; RATS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLUENE;

EID: 84863306063     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.334565     Document Type: Article

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