Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity

Journal of Neurochemistry

Volumn 122, Issue 2, 2012, Pages 356-362

  Oda, Ayako ^a   Kaneko, Kentaro ^a   Mizushige, Takafumi ^a   Lazarus, Michael ^b   Urade, Yoshihiro ^b   Ohinata, Kousaku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

A2A receptor; anxiolytic like activity; bioactive peptide; DP 1 receptor; GABAA receptor; ovalbumin

Indexed keywords

3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; 4 AMINOBUTYRIC ACID A RECEPTOR; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR; BICUCULLINE; INDOMETACIN; OVALBUMIN; OVOLIN; PENTAPEPTIDE; PROSTAGLANDIN D2; PROSTAGLANDIN D2 RECEPTOR 1; PROSTAGLANDIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; MALE; MAZE TEST; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANQUILIZING ACTIVITY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; INDICATORS AND REAGENTS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MOTOR ACTIVITY; OVALBUMIN; PEPTIDE FRAGMENTS; PEPTIDES; PROSTAGLANDIN D2; PROTEIN HYDROLYSATES; RECEPTOR, ADENOSINE A2A; RECEPTORS, GABA-A; RECEPTORS, PROSTAGLANDIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPSIN;

MUS;

EID: 84863302518     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07777.x     Document Type: Article

References (20)

1. Beuckmann C. T., Lazarus M., Gerashchenko D., et al. (2000) Cellular localization of lipocalin-type prostaglandin D synthase (beta-trace) in the central nervous system of the adult rat. J Comp Neurol. 428, 62-78.
2. Eguchi N., Minami T., Shirafuji N., Kanaoka Y., Tanaka T., Nagata A., Yoshida N., Urade Y., Ito S., and, Hayaishi O., (1999) Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. Proc. Natl Acad. Sci. USA. 96, 726-730. (Pubitemid 29061276)
3. 2. FASEB J. 5, 2575-2581. (Pubitemid 21905808)
4. 1 receptors. Peptides 28, 1998-2003. (Pubitemid 47419104)
5. 1 receptor in mice. J. Neurochem. 119, 785-790.
6. Huang Z. L., Urade Y., and, Hayaishi O., (2007) Prostaglandins and adenosine in the regulation of sleep and wakefulness. Curr. Opin. Pharmacol. 7, 33-38. (Pubitemid 46238038)
7. Kaneko K., Lazarus M., Miyamoto C., et al,. (in press) Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin (PG) D synthase in mice. Mol. Nutr. Food Res.
8. A receptors in mice. FEBS Lett. 584, 599-604.
9. A receptors. Prostaglandins Other Lipid Mediat. 98, 17-22.
10. Mizoguchi A., Eguchi N., Kimura K., et al. (2001) Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proc. Natl Acad. Sci. USA. 98, 11674-11679. (Pubitemid 32928787)
11. 2 in rat brain, spinal cord and pituitary: nasal level and regional distribution. Life Sci. 31, 2093-2103. (Pubitemid 13213521)
12. Ohinata K., Agui S., and, Yoshikawa M., (2007) Soymorphins, novel μ opioid peptides derived from soy β-conglycinin β-subunit, have anxiolytic activities. Biosci. Biotechnol. Biochem. 71, 2618-2621. (Pubitemid 350106269)
13. 2 stimulates food intake via neuropeptide Y system in mice. FEBS Lett. 582, 679-684.
14. 2 in rats. Proc. Natl Acad. Sci. USA. 93, 5980-5984.
15. A receptors. FEBS Lett. 585, 2357-2362.
16. 2 in the hypothermia of rats caused by bacterial lipopolysaccaride. Proc. Natl Acad. Sci. USA. 79, 6093-6097. (Pubitemid 13249986)
17. Urade Y., Kitahama K., Ohishi H., Kaneko T., Mizuno N., and, Hayaishi O., (1993) Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. Proc Natl Acad Sci USA. 90, 9070-9074. (Pubitemid 23306453)
18. Yang S., Yunden J., Sonoda S., Doyama N., Liplowski A. W., Kawamura Y., and, Yoshikawa M., (2001) Rubiscolin, a delta selective opioid peptide derived from plant Rubisco. FEBS Lett. 509, 213-217. (Pubitemid 34015945)
19. 1 receptor in male ddY mice. Peptides 29, 629-632.
20. 1 receptor in mice. Prostaglandins Other Lipid Mediat. 88, 68-72.