Central PGE2 exhibits anxiolytic-like activity via EP 1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors

FEBS Letters

Volumn 585, Issue 14, 2011, Pages 2357-2362

  Suzuki, Chihiro ^a   Miyamoto, Chihiro ^a   Furuyashiki, Tomoyuki ^a,b   Narumiya, Shuh ^a,b   Ohinata, Kousaku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Anxiolytic activity; Dopamine D 1 receptor; EP1 receptor; EP4 receptor; GABAA receptor; Prostaglandin E2; Serotonin 5 HT1A receptor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DOPAMINE 1 RECEPTOR; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; SEROTONIN 1A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ANXIOLYTIC AGENT; BENZAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; BICUCULLINE; FLUMAZENIL; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; PIPERAZINE DERIVATIVE; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; EMOTIONALITY; MALE; MAZE TEST; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; REGULATORY MECHANISM; ANIMAL; ANIMAL BEHAVIOR; BRAIN; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; MOUSE MUTANT; NEUROPSYCHOLOGICAL TEST; PHYSIOLOGY;

MUS;

ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; BENZAZEPINES; BICUCULLINE; BRAIN; DINOPROSTONE; FLUMAZENIL; GABA MODULATORS; GABA-A RECEPTOR ANTAGONISTS; MALE; MICE; MICE, KNOCKOUT; NEUROPSYCHOLOGICAL TESTS; PIPERAZINES; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, DOPAMINE D1; RECEPTORS, GABA-A; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; SEROTONIN ANTAGONISTS;

EID: 79960381372     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.06.004     Document Type: Article

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