Complement C5a exhibits anxiolytic-like activity via the prostaglandin D 2-DP 1 receptor system coupled to adenosine A 2A and GABA A receptors

Prostaglandins and Other Lipid Mediators

Volumn 98, Issue 1-2, 2012, Pages 17-22

  Miyamoto, Chihiro ^a,b   Yoshida, Mariko ^a,b   Yoshikawa, Masaaki ^a,b   Mizushige, Takafumi ^a   Ohinata, Kousaku ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Adenosine A 2A receptor; Anxiolytic activity; Complement C5a; DP 1 receptor; GABA A receptor; Prostaglandin D 2

Indexed keywords

3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; BICUCULLINE; COMPLEMENT COMPONENT C5A; INDOMETACIN; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; PROSTAGLANDIN D2; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN DP1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG MECHANISM; MALE; MAZE TEST; MOUSE; NONHUMAN; PROTEIN FUNCTION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; BICUCULLINE; COMPLEMENT C5A; HYDANTOINS; INDOMETHACIN; MALE; MICE; RECEPTOR, ADENOSINE A2A; RECEPTORS, GABA-A; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN;

EID: 84860783578     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2012.03.004     Document Type: Article

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