The cellular recognition of pathogenic DNA and the related regulation of innate immunity

Progress in Biochemistry and Biophysics

Volumn 38, Issue 12, 2011, Pages 1099-1105

  Xing, Ya Ling ^a   Zheng, Yang ^a   Wang, Kai ^a   Chen, Xiao Juan ^a   Chen, Zhong Bin ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

DNA sensor; IFN; Innate immunity; Pathogenic DNA

Indexed keywords

EID: 84863296187     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2011.00135     Document Type: Article

References (45)

1. Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science, 2010, 327(5963):291-295
2. Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol, 2009, 21(4):317-337
3. Muruve D A, Petrilli V, Zaiss A K, et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature, 2008, 452(7183):103-107 (Pubitemid 351355095)
4. Baum A, Sachidanandam R, Garcia-Sastre A. Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing. Proc Natl Acad Sci USA, 2010, 107(37):16303-16308
5. Yoneyama M, Fujita T. RNA recognition and signal transduction by RIG-I-like receptors. Immunol Rev, 2009, 227(1):54-65
6. Sun Q, Sun L, Liu H H, et al. The specific and essential role of MAVS in antiviral innate immune responses. Immunity, 2006, 24(5):633-642 (Pubitemid 43728147)
7. Nagata S, Hanayama R, Kawane K. Autoimmunity and the clearance of dead cells. Cell, 2010, 140(5):619-30
8. Rouse B.T., Sehrawat S. Immunity and immunopathology to viruses: what decides the outcome?. Nat Rev Immunol, 2010, 10(7):514-526
9. Randall R E, Goodbourn S. Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol, 2008, 89 (part 1):1-47
10. Xing Y L, Ren L N, Chen X J, et al. China Biotechnology, 2010, 30(10):60-65
11. Ishikawa H, Barber G N. The STING pathway and regulation of innate immune signaling in response to DNA pathogens. Cell Mol Life Sci, 2011, 68(7):1157-1165
12. Barbalat R, Ewald S E, Mouchess M L, et al. Nucleic acid recognition by the innate immune system. Annu Rev Immunol, 2011, 29:185-214
13. Ishikawa H, Barber G N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature, 2008, 455(7213):674-678
14. Zhong B, Yang Y, Li S, et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity, 2008, 29(4):538-550
15. Sun W, Li Y, Chen L, et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci USA, 2009, 106(21):8653-8658
16. Goubau D, Rehwinkel J, Sousa C R. PYHIN proteins: center stage in DNA sensing. Nature Immunology, 2010, 11(11):984-986
17. Ishikawa H, Ma Z, Barber G N. STING regulates intra-cellular DNA-mediated, type I interferon-dependent innate immunity. Nature, 2009, 461(7265):788-792
18. Blasius A L, Beutler B. Intracellular Toll-like receptors. Immunity, 2010, 32(3):305-315
19. Dixit E, Boulant S, Zhang Y, et al. Peroxisomes are signaling platforms for antiviral innate immunity. Cell, 2010, 141(4):668-681
20. Zhong B, Yang Y, Li S, et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity, 2008, 29(4):538-550
21. Saitoh T, Fujita N, Hayashi T, et al. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci USA, 2009, 106(49):20842-20846
22. Chen Z B, Sun L, Liu D B, et al. Human coronavirus papain-like proteases negatively regulate antiviral defences through disruption of MITA-mediated signaling//The 3rd Wuhan International Symposium on Modern Virology. Wuhan: State Key Laboratory of Virology, 2009:31
23. Ablasser A, Bauernfeind F, Hartmann G, et al. RIG-I-dependent sensing of poly (dA: dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol, 2009, 10(10):1065-1072
24. Chiu Y H, Macmillan J B, Chen Z J. RNA polymerase I detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell, 2009, 138(3):576-591
25. Chiu Y H, MacMillan J B, Chen Z J. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I Pathway. Cell, 2009, 138(3):1-16
26. De Filippis V R, Alvarado D, Sali T, et al. Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. J Virol, 2010, 84(1):585-598
27. Burckstummer T, Baumann C, Bluml S, et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol, 2009, 10(3):266-272
28. Roberts T L, Idris A, Dunn J A, et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 2009, 323(5917):1057-1060
29. Fernandes-Alnemri T, Yu J W, Datta P, et al. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature, 2009, 458(7237):509-513
30. Hornung V, Ablasser A, Charrel-Dennis M, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature, 2009, 458(7237):514-518
31. Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature, 2000, 408(6813):740-745 (Pubitemid 32015992)
32. Cao W, Manicassamy S, Tang H, et al. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamy-cin-sensitive PI (3) K-mTOR-p70S6K pathway. Nat Immunol, 2008, 9(10):1157-1164
33. Zimmerman J, Maher L J. Transient HMGB protein interactions with B-DNA duplexes and complexes. Biochem Biophys Res Commun, 2008, 371(1):79-84
34. Stros M. HMGB proteins: interactions with DNA and chromatin. Biochim Biophys Acta, 2010, 1799(1-2): 101-113
35. Yanai H, Ban T, Wang Z, et al. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature, 2009, 462(7269):99-103
36. Kim T, Pazhoor S, Bao M, et al. Aspartate-glutamate-alaninehistidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci USA, 2010, 107(34):15181-15186
37. Liu Z, Kenworthy R, Green C, et al. Molecular determinants of nucleolar translocation of RNA helicase A. Exp Cell Res, 2007, 313(17):3743-3754 (Pubitemid 47464238)
38. Huo L, Wang Y N, Xia W, et al. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc Natl Acad Sci USA, 2010, 107(37):16125-16130
39. Fenton K, Fismen S, Hedberg A, et al. Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW) F1 mice. PLoS One, 2009, 4(12): e8474
40. Kawane K, Ohtani M, Miwa K, et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature, 2006, 443(7114):998-1002 (Pubitemid 44646177)
41. Nickerson K M, Christensen S R, Shupe J, et al. TLR9 regulates TLR7-and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol, 2010, 184(4):1840-1848
42. Stetson D B, Ko J S, Heidmann T, et al. Trex1 prevents cellintrinsic initiation of autoimmunity. Cell, 2008, 134(4):587-598
43. Geijtenbeek T B H. Host DNase TREX1 hides HIV from DNA sensors. Nature Immunology, 2010, 11(11):979-980
44. Barton G M, Kagan J C, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol, 2006, 7(1):49-56 (Pubitemid 41823868)
45. Sun L, Yang Y D, Liu D B, et al. Prog Biochem Biophys, 2010, 37(8):871-880