Curcumin induces apoptosis involving Bax/Bcl-2 in human hepatoma SMMC-7721 cells

Asian Pacific Journal of Cancer Prevention

Volumn 12, Issue 8, 2011, Pages 1925-1929

  Yu, Jun ^a   Zhou, Xiaoming ^a   He, Xiaosong ^a   Dai, Meihong ^a   Zhang, Qin ^a  

^a JIANGSU CANCER HOSPITAL   (China)

Author keywords

Apoptosis; Bax; Bcl 2; Curcumin; Human hepatoma SMMC 7721 cells

Indexed keywords

EID: 84863292620     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Adhikari S, Indira Priyadarsini K, et al (2007). Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants. J Clin Biochem Nutr, 40, 174-83.
2. Bakhshi J, Weinstein L, et al (2008). Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin. Apoptosis, 13, 904-14.
3. Cheng CY, Lin YH, et al (2010). Curcumin inhibits the proliferation of human hepatocellular carcinoma J5 cells by inducing endoplasmic reticulum stress and mitochondrial dysfunction. Int J Mol Med, 26, 673-8.
4. Ghobrial IM, Witzig TE, et al (2005). Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin, 55, 178-94.
5. Green DR (2005). Apoptotic pathways: ten minutes to dead.Cell, 121, 671-4.
6. Jana NR, Dikshit P, et al (2004). Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J Biol Chem, 279, 11680-5.
7. Jia WD, Sun HC, et al (2007). A novel peptide that selectively binds highly metastatic hepatocellular carcinoma cell surface is related to invasion and metastasis. Cancer Lett, 247, 234-42.
8. Johnstone RW, Ruefli AA, et al (2002). Apoptosis: a link between cancer genetics and chemotherapy. Cell, 108, 153-64.
9. Kawai-Yamada M, Saito Y, et al. (2005). A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae. J Biol Chem, 280, 39468-73.
10. Kerr JF, Wyllie AH, et al (1972). Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer, 26, 239-57.
11. Kim DC, Kim SH, et al (2005). Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biol Pharm Bull, 28, 2220-4.
12. Klein S, McCormick F, et al (2005). Killing time for cancer cells. Nat Rev Cancer, 5, 573-80.
13. Martin SJ, Reutelingsperger CP, et al (1995). Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med, 182, 1545-56.
14. Pettersson F, Colston KW, et al (2001). Retinoic acid enhances the cytotoxic effects of gemcitabine and cisplatin in pancreatic adenocarcinoma cells. Pancreas, 23, 273-9.
15. Pettersson F, Dalgleish AG, et al (2002). Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. Br J Cancer, 87, 555-61.
16. Rashmi R, Kumar S, et al (2005). Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. Carcinogenesis, 26, 713-23.
17. Sato T, Hanada M, et al (1994). Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci USA, 91, 9238-42.
18. Sharma RA, Gescher AJ, et al (2005). Curcumin: the story so far. Eur J Cancer, 41, 1955-68.
19. Shu JC, He YJ, et al (2009). Effect of curcumin on the proliferation and apoptosis of hepatic stellate cells. Braz J Med Biol Res, 42, 1173-8.
20. Su CC, Yang JS, et al (2008). Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo. In Vivo, 22, 63-8.
21. Syng-Ai, C., A. L. Kumari, et al. (2004). Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2. Mol Cancer Ther, 3, 1101-8.
22. Tamm I, Schriever F, et al (2001). Apoptosis: implications of basic research for clinical oncology. Lancet Oncol, 2, 33-42.
23. Wang L, Wang L, et al (2011). Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma. Mol Cancer Ther.
24. Wu SH, Hang LW, et al (2010). Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways. Anticancer Res, 30, 2125-33.
25. Xu K, Thornalley PJ (2001). Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro. Biochem Pharmacol, 61, 165-77.
26. Ziegler DS, Kung AL (2008). Therapeutic targeting of apoptosis pathways in cancer. Curr Opin Oncol, 20, 97-103.