Structural insights into apoptotic DNA degradation by CED-3 protease suppressor-6 (CPS-6) from Caenorhabditis elegans

Journal of Biological Chemistry

Volumn 287, Issue 10, 2012, Pages 7110-7120

  Lin, Jason L J ^a   Nakagawa, Akihisa ^b   Lin, Chia Liang ^a,c   Hsiao, Yu Yuan ^a   Yang, Wei Zen ^a   Wang, Yi Ting ^a   Doudeva, Lyudmila G ^a   Skeen Gaar, Riley Robert ^b   Xue, Ding ^b   Yuan, Hanna S ^a,d  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^b UNIVERSITY OF COLORADO   (United States)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; APOPTOTIC; CAENORHABDITIS ELEGANS; CELL KILLING; CLEAVAGE ACTIVITIES; DIMERIC ENZYME; DNA BINDING; DNA DEGRADATION; DNASE ACTIVITY; ELEGANS; ENDONUCLEASES; IN-VIVO; MITOCHONDRIAL PROTEIN; MOLECULAR BASIS; POSITIVELY CHARGED; PROTEIN-DNA INTERFACE; SALT BUFFER; STRUCTURAL INSIGHTS; STRUCTURAL MODELS;

CELL DEATH; DEGRADATION; MODEL STRUCTURES;

DNA;

ARGININE; CED 3 PROTEASE SUPPRESSOR 6; DEOXYRIBONUCLEASE; ENDONUCLEASE G; MAGNESIUM ION; MUTANT PROTEIN; NUCLEASE; PHENYLALANINE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL CELL; APOPTOSIS; AROMATIZATION; ARTICLE; BETA CHAIN; CAENORHABDITIS ELEGANS; CELL KILLING; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; DNA BINDING; DNA DEGRADATION; DNA FRAGMENTATION; DNA PROTEIN COMPLEX; ENZYME ACTIVITY; IN VIVO STUDY; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTEIN LOCALIZATION; PROTEIN MOTIF; RESIDUE ANALYSIS; RNA DEGRADATION; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CRYSTALLOGRAPHY, X-RAY; DNA, HELMINTH; ENDODEOXYRIBONUCLEASES; HYDROLYSIS; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MUTATION, MISSENSE; STRUCTURE-ACTIVITY RELATIONSHIP;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 84863286813     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.316075     Document Type: Article

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