The roles and acting mechanism of Caenorhabditis elegans DNase II genes in apoptotic DNA degradation and development

PLoS ONE

Volumn 4, Issue 10, 2009, Pages

  Lai, Huey Jen ^a,b   Lo, Szecheng J ^b   Kage Nakadai, Eriko ^c   Mitani, Shohei ^c   Xue, Ding ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CAENORHABDITIS ELEGANS PROTEIN; CELL DEATH RELATED NUCLEASE 6; CELL DEATH RELATED NUCLEASE 7; DEOXYRIBONUCLEASE; DEOXYRIBONUCLEASE II; NUCLEASE; PROTEIN NUC 1; UNCLASSIFIED DRUG; DNA; GREEN FLUORESCENT PROTEIN;

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DNA DEGRADATION; DNA STRAND BREAKAGE; EMBRYO; ENZYME ACTIVITY; GENOTYPE; NICK END LABELING; NONHUMAN; PHAGOCYTE; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; DNA DAMAGE; GENE EXPRESSION REGULATION; GENOME; INTESTINE; KINETICS; METABOLISM; PHYSIOLOGY; TRANSGENIC ANIMAL;

BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; CAENORHABDITIS ELEGANS; DEOXYRIBONUCLEASES; DNA; DNA DAMAGE; ENDODEOXYRIBONUCLEASES; GENE EXPRESSION REGULATION; GENOME; GREEN FLUORESCENT PROTEINS; INTESTINES; KINETICS; PHAGOCYTES;

EID: 70350227092     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007348     Document Type: Article

References (48)

1. Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556.
2. Steller H (1995) Mechanisms and genes of cellular suicide. Science 267: 1445-1449.
3. Parrish JZ, Xue D (2006) Cuts can kill: the roles of apoptotic nucleases in cell death and animal development. Chromosoma 115: 89-97.
4. Liu X, Zou H, Slaughter C, Wang X (1997) DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89: 175-184.
5. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, et al. (1998) A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391: 43-50.
6. Widlak P, Garrard WT (2009) Roles of the major apoptotic nuclease-DNA fragmentation factor-in biology and disease. Cell Mol Life Sci 66: 263-274.
7. Widlak P, Garrard WT (2001) Ionic and cofactor requirements for the activity of the apoptotic endonuclease DFF40/CAD. Mol Cell Biochem 218: 125-130.
8. Zhang J, Liu X, Scherer DC, van Kaer L, Wang X, et al. (1998) Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc Natl Acad Sci U S A 95: 12480-12485.
9. McIlroy D, Tanaka M, Sakahira H, Fukuyama H, Suzuki M, et al. (2000) An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes. Genes Dev 14: 549-558.
10. Kawane K, Fukuyama H, Yoshida H, Nagase H, Ohsawa Y, et al. (2003) Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat Immunol 4: 138-144.
11. Counis MF, Torriglia A (2006) Acid DNases and their interest among apoptotic endonucleases. Biochimie 88: 1851-1858.
12. Gottlieb RA, Nordberg J, Skowronski E, Babior BM (1996) Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc Natl Acad Sci U S A 93: 654-658.
13. Bernardi G (1971) Spleen acid deoxyribonuclease. In: Boyer PD, ed. Hydrolysis. New York: Acdamic Press. pp 271-287.
14. Yamanaka M, Tsubota Y, Anai M, Ishimatsu K, Okumura M, et al. (1974) Purification and properties of acid deoxyribonucleases of human gastric mucosa and cervix uteri. J Biol Chem 249: 3884-3889.
15. Evans CJ, Aguilera RJ (2003) DNase II: genes, enzymes and function. Gene 322: 1-15.
16. Shiokawa D, Tanuma S (1999) DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II. Nucleic Acids Res 27: 4083-4089.
17. Krieser RJ, MacLea KS, Park JP, Eastman A (2001) The cloning, genomic structure, localization, and expression of human deoxyribonuclease IIbeta. Gene 269: 205-216.
18. Yasuda T, Takeshita H, Iida R, Nakajima T, Hosomi O, et al. (1998) Molecular cloning of the cDNA encoding human deoxyribonuclease II. J Biol Chem 273: 2610-2616.
19. Shiokawa D, Tanuma S (1998) Cloning of cDNAs encoding porcine and human DNase II. Biochem Biophys Res Commun 247: 864-869.
20. Kawane K, Fukuyama H, Kondoh G, Takeda J, Ohsawa Y, et al. (2001) Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science 292: 1546-1549.
21. Nishimoto S, Kawane K, Watanabe-Fukunaga R, Fukuyama H, Ohsawa Y, et al. (2003) Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens. Nature 424: 1071-1074.
22. Li LY, Luo X, Wang X (2001) Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412: 95-99.
23. Wu YC, Stanfield GM, Horvitz HR (2000) NUC-1, a Caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis. Genes Dev 14: 536-548.
24. Parrish J, Li L, Klotz K, Ledwich D, Wang X, et al. (2001) Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature 412: 90-94.
25. Parrish JZ, Xue D (2003) Functional genomic analysis of apoptotic DNA degradation in C. elegans. Mol Cell 11: 987-996.
26. Hedgecock EM, Sulston JE, Thomson JN (1983) Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans. Science 220: 1277-1279.
27. Kaufmann SH, Mesner PW Jr, Samejima K, Tone S, Earnshaw WC (2000) Detection of DNA cleavage in apoptotic cells. Methods Enzymol 322: 3-15.
28. Alnemri ES, Litwack G (1990) Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s). J Biol Chem 265: 17323-17333.
29. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501.
30. Sulston JE, Schierenberg E, White JG, Thomson JN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100: 64-119.
31. Ellis HM, Horvitz HR (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44: 817-829.
32. Shaham S, Reddien PW, Davies B, Horvitz HR (1999) Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3. Genetics 153: 1655-1671.
33. Lyon CJ, Evans CJ, Bill BR, Otsuka AJ, Aguilera RJ (2000) The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II. Gene 252: 147-154.
34. Sulston JE, Horvitz HR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56: 110-156.
35. Ardizzi JP, Epstein HF (1987) Immunochemical localization of myosin heavy chain isoforms and paramyosin in developmentally and structurally diverse muscle cell types of the nematode Caenorhabditis elegans. J Cell Biol 105: 2763-2770.
36. Ellis RE, Jacobson DM, Horvitz HR (1991) Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics 129: 79-94.
37. Mukae N, Yokoyama H, Yokokura T, Sakoyama Y, Nagata S (2002) Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation. Genes Dev 16: 2662-2671.
38. Seong CS, Varela-Ramirez A, Aguilera RJ (2006) DNase II deficiency impairs innate immune function in Drosophila. Cell Immunol 240: 5-13.
39. MacLea KS, Krieser RJ, Eastman A (2002) Revised structure of the active form of human deoxyribonuclease IIalpha. Biochem Biophys Res Commun 292: 415-421.
40. Baker KP, Baron WF, Henzel WJ, Spencer SA (1998) Molecular cloning and characterization of human and murine DNase II. Gene 215: 281-289.
41. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
42. Maduro M, Pilgrim D (1995) Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141: 977-988.
43. Hodgkin J (1983) Male Phenotypes and Mating Efficiency in Caenorhabditis elegans. Genetics 103: 43-64.
44. Hodgkin J, Horvitz HR, Brenner S (1979) Nondisjunction Mutants of the Nematode Caenorhabditis elegans. Genetics 91: 67-94.
45. Sulston JE (1976) Post-embryonic development in the ventral cord of Caenorhabditis elegans. Philos Trans R Soc Lond B Biol Sci 275: 287-297.
46. Seydoux G, Fire A (1994) Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans. Development 120: 2823-2834.
47. Mello CC, Kramer JM, Stinchcomb D, Ambros V (1991) Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10: 3959-3970.
48. Praitis V, Casey E, Collar D, Austin J (2001) Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics 157: 1217-1226.