-
1
-
-
33746624000
-
Systemic Therapy of Advanced Hepatocellular Carcinoma: How Hopeful Should We Be?
-
Zhu AX Systemic Therapy of Advanced Hepatocellular Carcinoma: How Hopeful Should We Be?. Oncologist 2006, 11:790-800.
-
(2006)
Oncologist
, vol.11
, pp. 790-800
-
-
Zhu, A.X.1
-
2
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008, 359:378-390.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
3
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009, 10:25-34.
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
-
4
-
-
77953691719
-
Sorafenib. A review of its use in hepatocellular carcinoma
-
Keating GM, Santoro A Sorafenib. A review of its use in hepatocellular carcinoma. Drugs 2009, 69:1-17.
-
(2009)
Drugs
, vol.69
, pp. 1-17
-
-
Keating, G.M.1
Santoro, A.2
-
5
-
-
33749017926
-
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
-
Abou-Alfa GK, Schwartz L, Ricci S, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006, 24:4293-4300.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4293-4300
-
-
Abou-Alfa, G.K.1
Schwartz, L.2
Ricci, S.3
-
6
-
-
68249153302
-
Early MRI response monitoring of patients with advanced hepatocellular carcinoma under treatment with the multikinase inhibitor sorafenib
-
Horger M, Lauer UM, Schraml C, et al. Early MRI response monitoring of patients with advanced hepatocellular carcinoma under treatment with the multikinase inhibitor sorafenib. BMC Cancer 2009, 9:208.
-
(2009)
BMC Cancer
, vol.9
, pp. 208
-
-
Horger, M.1
Lauer, U.M.2
Schraml, C.3
-
7
-
-
44449085884
-
Design and endpoints of clinical trials in hepatocellular carcinoma
-
Llovet JM, Di Bisceglie AM, Bruix J, et al. Design and endpoints of clinical trials in hepatocellular carcinoma. J Nati Cancer Inst 2008, 100:698-711.
-
(2008)
J Nati Cancer Inst
, vol.100
, pp. 698-711
-
-
Llovet, J.M.1
Di Bisceglie, A.M.2
Bruix, J.3
-
8
-
-
68849110551
-
Sorafenib therapy in advanced hepatocellular carcinoma: the SHARP trial
-
Rimassa L, Santoro A Sorafenib therapy in advanced hepatocellular carcinoma: the SHARP trial. Expert Rev Anticancer Ther 2009, 9:739-745.
-
(2009)
Expert Rev Anticancer Ther
, vol.9
, pp. 739-745
-
-
Rimassa, L.1
Santoro, A.2
-
9
-
-
77953700530
-
Serial alpha-fetoprotein evaluation and survival in hepatocellular carcinoma patients treated with sorafenib
-
(abstr. 6616).
-
Personeni N, Bozzarelli S, Giordano L, et al. Serial alpha-fetoprotein evaluation and survival in hepatocellular carcinoma patients treated with sorafenib. Eur J Cancer 2009, 7:394. (abstr. 6616).
-
(2009)
Eur J Cancer
, vol.7
, pp. 394
-
-
Personeni, N.1
Bozzarelli, S.2
Giordano, L.3
-
10
-
-
61449256583
-
Sorafenib in unresectable hepatocellular carcinoma from mild to advanced stage liver cirrhosis
-
Pinter M, Sieghart W, Graziadei I, et al. Sorafenib in unresectable hepatocellular carcinoma from mild to advanced stage liver cirrhosis. Oncologist 2009, 14:70-76.
-
(2009)
Oncologist
, vol.14
, pp. 70-76
-
-
Pinter, M.1
Sieghart, W.2
Graziadei, I.3
-
11
-
-
67651095716
-
Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis
-
Worns MA, Weinmann A, Pfingst K, et al. Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis. J Clin Gastroenterol 2009, 43:489-495.
-
(2009)
J Clin Gastroenterol
, vol.43
, pp. 489-495
-
-
Worns, M.A.1
Weinmann, A.2
Pfingst, K.3
-
12
-
-
77953725260
-
-
Final results from a phase II (Phil), randomized, double-blind study of sorafenib plus doxoru-bicin (S+D) versus placebo plus doxorubicin (P+D) in patients (pts) with advanced hepatocellular carcinoma (AHCC). Gastrointestinal Cancer Symposium. Orlando (El), USA, 25-27 January 2008 (abstr. 128).
-
Abou-alfa GK, Johnson P, Knox J, et al. Final results from a phase II (Phil), randomized, double-blind study of sorafenib plus doxoru-bicin (S+D) versus placebo plus doxorubicin (P+D) in patients (pts) with advanced hepatocellular carcinoma (AHCC). 2008 Gastrointestinal Cancer Symposium. Orlando (El), USA, 25-27 January 2008 (abstr. 128).
-
(2008)
-
-
Abou-alfa G.K1
Johnson, P.2
Knox, J.3
-
13
-
-
60449093312
-
Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: results from a phase I extension trial
-
Richly H, Schultheis B, Adamietz IA, et al. Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: results from a phase I extension trial. Eur J Cancer 2009, 45:579-587.
-
(2009)
Eur J Cancer
, vol.45
, pp. 579-587
-
-
Richly, H.1
Schultheis, B.2
Adamietz, I.A.3
-
14
-
-
77955821208
-
A phase II study of sorafenib in combination with tegafur/uracil (UFT) for Asian patients with advanced hepatocellular carcinoma (HCC)
-
(abstr. 4589).
-
Shen Y, Hsu C, Hsu C, et al. A phase II study of sorafenib in combination with tegafur/uracil (UFT) for Asian patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol 2009, 27:223s. (abstr. 4589).
-
(2009)
J Clin Oncol
, vol.27
-
-
Shen, Y.1
Hsu, C.2
Hsu, C.3
-
15
-
-
77955796298
-
A phase II (Phil) study of sorafenib (S) in combination with 5-fluorouracil (5FU) continuous infusion (ci.) in patients with advanced hepatocellular carcinoma (HCC): preliminary data
-
(abstr. 4592)
-
Petrini I, Lencioni M, Ricasoli M, et al. A phase II (Phil) study of sorafenib (S) in combination with 5-fluorouracil (5FU) continuous infusion (ci.) in patients with advanced hepatocellular carcinoma (HCC): preliminary data. J Clin Oncol 2009, 27:224s. (abstr. 4592).
-
(2009)
J Clin Oncol
, vol.27
-
-
Petrini, I.1
Lencioni, M.2
Ricasoli, M.3
-
16
-
-
27244447373
-
Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer
-
Philip PA, Mahoney MR, Allmer C, et al. Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005, 23:6657-6663.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6657-6663
-
-
Philip, P.A.1
Mahoney, M.R.2
Allmer, C.3
-
17
-
-
34548150925
-
Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
-
Thomas MB, Chadha R, Glover K, et al. Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer 2007, 110:1059-1067.
-
(2007)
Cancer
, vol.110
, pp. 1059-1067
-
-
Thomas, M.B.1
Chadha, R.2
Glover, K.3
-
18
-
-
46449091500
-
Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
-
Siegel AB, Cohen EI, Ocean A, et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol 2008, 26:2992-2998.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2992-2998
-
-
Siegel, A.B.1
Cohen, E.I.2
Ocean, A.3
-
19
-
-
33646351795
-
Phase II study of gemcita-bine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
-
Zhu AX, Blaszkowsky LS, Ryan DP, et al. Phase II study of gemcita-bine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006, 24:1898-1903.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1898-1903
-
-
Zhu, A.X.1
Blaszkowsky, L.S.2
Ryan, D.P.3
-
20
-
-
42049095494
-
Modified-dose capecitabine + bevacizumab for the treatment of advanced/metastatic hepatocellular carcinoma (HCC): A phase II, single-arm study
-
(abstr. 15190)
-
Hsu C, Yang T, Hsu C, et al. Modified-dose capecitabine + bevacizumab for the treatment of advanced/metastatic hepatocellular carcinoma (HCC): A phase II, single-arm study. J Clin Oncol 2007, 25:649s. (abstr. 15190).
-
(2007)
J Clin Oncol
, vol.25
-
-
Hsu, C.1
Yang, T.2
Hsu, C.3
-
21
-
-
36549089272
-
Combination of capecitabine, oxaliplatin with bevacizumab in treatment of advanced hepatocellular carcinoma (HCC): A phase II study
-
(abstr. 4574)
-
Sun W, Haller DG, Mykulowicz K, et al. Combination of capecitabine, oxaliplatin with bevacizumab in treatment of advanced hepatocellular carcinoma (HCC): A phase II study. J Clin Oncol 2007, 25:216s. (abstr. 4574).
-
(2007)
J Clin Oncol
, vol.25
-
-
Sun, W.1
Haller, D.G.2
Mykulowicz, K.3
-
22
-
-
60849124241
-
Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma
-
Thomas MB, Morris JS, Chadha R, et al. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol 2009, 27:843-850.
-
(2009)
J Clin Oncol
, vol.27
, pp. 843-850
-
-
Thomas, M.B.1
Morris, J.S.2
Chadha, R.3
-
23
-
-
67649946279
-
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study
-
Zhu AX, Sahani DV, Duda DG, et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol 2009, 27:3027-3035.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3027-3035
-
-
Zhu, A.X.1
Sahani, D.V.2
Duda, D.G.3
-
24
-
-
67651165187
-
Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study
-
Faivre S, Raymond E, Boucher E, et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol 2009, 10:794-800.
-
(2009)
Lancet Oncol
, vol.10
, pp. 794-800
-
-
Faivre, S.1
Raymond, E.2
Boucher, E.3
-
25
-
-
33750915657
-
Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial
-
(abstr. 4010)
-
Ramanathan RK, Belani CP, Singh DA, et al. Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial. J Clin Oncol 2006, 24:181s. (abstr. 4010).
-
(2006)
J Clin Oncol
, vol.24
-
-
Ramanathan, R.K.1
Belani, C.P.2
Singh, D.A.3
-
26
-
-
70349443677
-
A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinoma
-
Bekaii-Saab T, Markowitz J, Prescott N, et al. A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinoma. Clin Cancer Res 2009, 15:5895-5901.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5895-5901
-
-
Bekaii-Saab, T.1
Markowitz, J.2
Prescott, N.3
-
27
-
-
34547102484
-
Phase 2 study of ce-tuximab in patients with advanced hepatocellular carcinoma
-
Zhu AX, Stuart K, Blaszkowsky LS, et al. Phase 2 study of ce-tuximab in patients with advanced hepatocellular carcinoma. Cancer 2007, 110:581-589.
-
(2007)
Cancer
, vol.110
, pp. 581-589
-
-
Zhu, A.X.1
Stuart, K.2
Blaszkowsky, L.S.3
-
28
-
-
46049097410
-
Gemcitabine plus oxaliplatin-(GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma: results of a multicenter phase 2 study
-
Asnacios A, Fartoux L, Romano O, et al. Gemcitabine plus oxaliplatin-(GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma: results of a multicenter phase 2 study. Cancer 2008, 112:2733-2739.
-
(2008)
Cancer
, vol.112
, pp. 2733-2739
-
-
Asnacios, A.1
Fartoux, L.2
Romano, O.3
-
29
-
-
74549223962
-
An open label phase II study of first-and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC)
-
(abstr. 4577)
-
Raoul JL, Fin RS, Kang YK, et al. An open label phase II study of first-and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC). J Clin Oncol 2009, 27:221s. (abstr. 4577).
-
(2009)
J Clin Oncol
, vol.27
-
-
Raoul, J.L.1
Fin, R.S.2
Kang, Y.K.3
-
30
-
-
59149090277
-
Final result of a phase I/II trial of the oral anti-angiogenesis inhibitor TSU-68 in patients with advanced hepatocellular carcinoma
-
(abstr. 4589)
-
Kanai K, Yoshida H, Tateishi R, et al. Final result of a phase I/II trial of the oral anti-angiogenesis inhibitor TSU-68 in patients with advanced hepatocellular carcinoma. J Clin Oncol 2008, 26:235s. (abstr. 4589).
-
(2008)
J Clin Oncol
, vol.26
-
-
Kanai, K.1
Yoshida, H.2
Tateishi, R.3
-
31
-
-
77953729187
-
-
NCCTG phase II trial (N044J) of AZD2171 for patients with hepatocellular carcinoma (HCC) -Interim review of toxicity. Gastrointestinal Cancer Symposium. Orlando (Fl), USA, January 2007 (abstr. 186).
-
Alberts SR, Morlan BW, Kim GR, et al. NCCTG phase II trial (N044J) of AZD2171 for patients with hepatocellular carcinoma (HCC) -Interim review of toxicity. 2007 Gastrointestinal Cancer Symposium. Orlando (Fl), USA, 19-21 January 2007 (abstr. 186).
-
(2007)
, pp. 19-21
-
-
Alberts, S.R.1
Morlan B.W2
Kim, G.R.3
-
32
-
-
39849106728
-
Influence of Hepatic Dysfunction on Safety, Tolerability, and Pharmacokinetics (PK) of PTK787/ZK 222584 in Patients (Pts) with Unresectable Hepatocellular Carcinoma (HCC)
-
(abstr. 4134)
-
Koch I, Baron A, Roberts S, et al. Influence of Hepatic Dysfunction on Safety, Tolerability, and Pharmacokinetics (PK) of PTK787/ZK 222584 in Patients (Pts) with Unresectable Hepatocellular Carcinoma (HCC). J Clin Oncol 2005, 23:341s. (abstr. 4134).
-
(2005)
J Clin Oncol
, vol.23
-
-
Koch, I.1
Baron, A.2
Roberts, S.3
-
33
-
-
69249149754
-
A phase II study of ABT-869 in hepatocellular carcinoma (HCC): interim analysis
-
(abstr. 4581)
-
Toh H, Chen P, Carr BI, et al. A phase II study of ABT-869 in hepatocellular carcinoma (HCC): interim analysis. J Clin Oncol 2009, 27:222s. (abstr. 4581).
-
(2009)
J Clin Oncol
, vol.27
-
-
Toh, H.1
Chen, P.2
Carr, B.I.3
-
34
-
-
84952976733
-
Phase II study of NGR-hTNF, a selective vascular targeting agent (VTA), in previously treated patients (pts) with advanced hepatocellular carcinoma (HCC)
-
(abstr. 6617)
-
Santoro A, Citterio G, Pressiani T, et al. Phase II study of NGR-hTNF, a selective vascular targeting agent (VTA), in previously treated patients (pts) with advanced hepatocellular carcinoma (HCC). Eur J Cancer 2009, 7:395. (abstr. 6617).
-
(2009)
Eur J Cancer
, vol.7
, pp. 395
-
-
Santoro, A.1
Citterio, G.2
Pressiani, T.3
-
35
-
-
77952085946
-
Randomized, phase I, and phar-macokinetic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC)
-
(abstr. 4587)
-
Chen L, Shiah HS, Chen CY, et al. Randomized, phase I, and phar-macokinetic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC). J Clin Oncol 2009, 27:223s. (abstr. 4587).
-
(2009)
J Clin Oncol
, vol.27
-
-
Chen, L.1
Shiah, H.S.2
Chen, C.Y.3
-
36
-
-
61449234114
-
A phase II study of oxaliplatin in combination with doxorabicin as first-line systemic chemotherapy in patients with inoperable hepatocellular carcinoma
-
Uhm JE, Park JO, Lee J, et al. A phase II study of oxaliplatin in combination with doxorabicin as first-line systemic chemotherapy in patients with inoperable hepatocellular carcinoma. Cancer Chemother Pharmacol 2009, 63:929-935.
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, pp. 929-935
-
-
Uhm, J.E.1
Park, J.O.2
Lee, J.3
-
37
-
-
33947495362
-
Gemcitabine plus oxaliplatin (GEMOX) in patients with advanced hepatocellular carcinoma (HCC): results of a phase II study
-
Louafi S, Boige V, Ducreux M, et al. Gemcitabine plus oxaliplatin (GEMOX) in patients with advanced hepatocellular carcinoma (HCC): results of a phase II study. Cancer 2007, 109:1384-1390.
-
(2007)
Cancer
, vol.109
, pp. 1384-1390
-
-
Louafi, S.1
Boige, V.2
Ducreux, M.3
-
38
-
-
69449106391
-
Combination chemotherapy with capecitabine and cisplatin for patients with metastatic hepatocellular carcinoma
-
Lee JO, Lee KW, Oh DY, et al. Combination chemotherapy with capecitabine and cisplatin for patients with metastatic hepatocellular carcinoma. Ann Oncol 2009, 20:1402-1407.
-
(2009)
Ann Oncol
, vol.20
, pp. 1402-1407
-
-
Lee, J.O.1
Lee, K.W.2
Oh, D.Y.3
-
39
-
-
65649102210
-
Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver: a retrospective study
-
Edeline J, Raoul JL, Vauleon E, et al. Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver: a retrospective study. World J Gastroenterol 2009, 15:713-716.
-
(2009)
World J Gastroenterol
, vol.15
, pp. 713-716
-
-
Edeline, J.1
Raoul, J.L.2
Vauleon, E.3
-
40
-
-
58749090909
-
New utility of an old marker: serial alpha-fetoprotein measurement in predicting radiologie response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy
-
Chan SL, Mo FK, Johnson PJ, et al. New utility of an old marker: serial alpha-fetoprotein measurement in predicting radiologie response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy. J Clin Oncol 2009, 27:446-452.
-
(2009)
J Clin Oncol
, vol.27
, pp. 446-452
-
-
Chan, S.L.1
Mo, F.K.2
Johnson, P.J.3
|