-
1
-
-
0003432464
-
-
Available at Accessed May 26, 2010
-
American Cancer Society. Cancer Facts & Figures 2009. Available at: http://www.cancer.org/downloads/STT/500809web.pdf. Accessed May 26, 2010.
-
(2009)
American Cancer Society. Cancer Facts & Figures
-
-
-
2
-
-
14944385553
-
Global cancer statistics 2002
-
Parkin DM, Bray F, FerlayJ, et al. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55:74-108.
-
(2005)
CA Cancer J Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Ferlayj, B.F.2
-
5
-
-
1342268525
-
American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: Update 2003
-
DOI 10.1200/JCO.2004.09.053
-
Pfister DG, Johnson DH, Azzoli CG, et al. American Society of Clinical Oncology treatment of unresectable non-small cell lung cancer guideline: update 2003. JClin Oncol2004; 22:330-53. (Pubitemid 41095099)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.2
, pp. 330-353
-
-
Pfister, D.G.1
Johnson, D.H.2
Azzoli, C.G.3
Sause, W.4
Smith, T.J.5
Baker Jr., S.6
Olak, J.7
Stover, D.8
Strawn, J.R.9
Turrisi, A.T.10
Somerfield, M.R.11
-
6
-
-
34249093653
-
Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non - Small cell lung cancer
-
DOI 10.1158/1078-0432.CCR-06-2889
-
Adjei AA, Molina JR, Mandrekar SJ, et al. Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small cell lung cancer. Clin Cancer Res 2007; 13:2684-91. (Pubitemid 46788036)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.9
, pp. 2684-2691
-
-
Adjei, A.A.1
Molina, J.R.2
Mandrekar, S.J.3
Marks, R.4
Reid, J.R.5
Croghan, G.6
Hanson, L.J.7
Jett, A.R.8
Xia, C.9
Lathia, C.10
Simantov, R.11
-
7
-
-
34447262600
-
Phase II study of erlotinib in advanced non-small-cell lung cancer after failure of gefitinib
-
DOI 10.1200/JCO.2006.10.4166
-
Cho BC, Im K-C, Park M-S, et al. Phase II study of erlotinib in advanced non-small-cell lung cancer after failure of gefitinib. J Clin Oncol 2007; 25:2528-33. (Pubitemid 47041225)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.18
, pp. 2528-2533
-
-
Byoung, C.C.1
Im, C.-K.2
Park, M.-S.3
Se, K.K.4
Chang, J.5
Jong, P.P.6
Hye, J.C.7
Yu, J.K.8
Shin, S.-J.9
Joo, H.S.10
Kim, H.11
Joo, H.K.12
-
8
-
-
33645999695
-
Long-term survival in three patients with metastatic non-small cell lung cancer treated with gefitinib
-
Nakatomi K, Soda H, Kitazaki T, et al. Long-term survival in three patients with metastatic non-small cell lung cancer treated with gefitinib. Lung Cancer 2006; 52:253-5.
-
(2006)
Lung Cancer
, vol.52
, pp. 253-255
-
-
Nakatomi, K.1
Soda, H.2
Kitazaki, T.3
-
9
-
-
24744445166
-
Benefit in lung function improvement and side-effect profile of long-term responders: An analysis of 14 NSCLC patients treated for at least 9 months with gefitinib
-
DOI 10.1016/j.lungcan.2005.05.006, PII S016950020500245X
-
Reck M, Gatzemeier U. Benefit in lung function improvement and side-effect profile of long-term responders: an analysis of 14 NSCLC patients treated for at least 9 months with gefitinib. Lung Cancer 2005; 50:107-14. (Pubitemid 41297477)
-
(2005)
Lung Cancer
, vol.50
, Issue.1
, pp. 107-114
-
-
Reck, M.1
Gatzemeier, U.2
-
10
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
DOI 10.1056/NEJMoa040938
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350:2129-39. (Pubitemid 38637993)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
11
-
-
2342624080
-
EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy
-
DOI 10.1126/science.1099314
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304:1497-500. (Pubitemid 38720929)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
12
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
DOI 10.1073/pnas.0405220101
-
Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004; 101:13306-11. (Pubitemid 39209661)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.36
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
Singh, B.7
Heelan, R.8
Rusch, V.9
Fulton, L.10
Mardis, E.11
Kupfer, D.12
Wilson, R.13
Kris, M.14
Varmus, H.15
-
13
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
DOI 10.1056/NEJMoa061884
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevaci-zumab for non-small-cell lung cancer. N Engl J Med 2006; 355:2542-50. (Pubitemid 44917502)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
14
-
-
36048982143
-
Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non-small-cell lung cancer
-
DOI 10.1200/JCO.2007.12.3026
-
Herbst RS, O'Neill VJ, Fehrenbacher L, et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 2007; 25:4743-50. (Pubitemid 350086476)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.30
, pp. 4743-4750
-
-
Herbst, R.S.1
O'Neill, V.J.2
Fehrenbacher, L.3
Belani, C.P.4
Bonomi, P.D.5
Hart, L.6
Melnyk, O.7
Ramies, D.8
Lin, M.9
Sandler, A.10
-
15
-
-
62449124416
-
Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL
-
Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL. J Clin Oncol 2009; 27:1227-34.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1227-1234
-
-
Reck, M.1
Von Pawel, J.2
Zatloukal, P.3
-
16
-
-
77951473661
-
Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL)
-
Reck M, von Pawel J, Zatloukal P, et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 2010; 21:1804-9.
-
(2010)
Ann Oncol
, vol.21
, pp. 1804-1809
-
-
Reck, M.1
Von Pawel, J.2
Zatloukal, P.3
-
17
-
-
55749088393
-
Preclinical overview of sorafenib, a mul-tikinase inhibitor that targets both Raf and VEGF and PDGF receptor signaling
-
Wilhelm SM, Adnane L, Newell P, et al. Preclinical overview of sorafenib, a mul-tikinase inhibitor that targets both Raf and VEGF and PDGF receptor signaling. Mol Cancer Ther 2008; 7:3129-40.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3129-3140
-
-
Wilhelm, S.M.1
Adnane, L.2
Newell, P.3
-
18
-
-
84976585919
-
-
European Medicines Agency Available at Accessed May 26, 2010
-
European Medicines Agency. Nexavar Summary of Product Characteristics. 2006. Available at: http://www.emea.europa.eu/humandocs/PDFs/EPAR/nexavar/emea- combined-h690en.pdf. Accessed May 26, 2010.
-
(2006)
Nexavar Summary of Product Characteristics.
-
-
-
19
-
-
78650882327
-
-
Nexavar (sorafenib) tablets [prescription information]: Wayne, NJ Available at Accessed May 26, 2010
-
Nexavar (sorafenib) tablets [prescription information]: Wayne, NJ. Bayer HealthCare Pharmaceuticals; 2009. Available at: http://berlex.bayerhealthcare. com/html/products/pi/Nexavar-PI.pdf. Accessed May 26, 2010.
-
(2009)
Bayer HealthCare Pharmaceuticals
-
-
-
20
-
-
78650084078
-
A front-line window of opportunity phase 2 study of sorafenib in patients with advanced nonsmall cell lung cancer
-
North Central Cancer Treatment Group Study N0326
-
Dy GK, Hillman SL, Rowland KM Jr, et al. A front-line window of opportunity phase 2 study of sorafenib in patients with advanced nonsmall cell lung cancer. North Central Cancer Treatment Group Study N0326. Cancer 2010; 116: 5686-93.
-
(2010)
Cancer
, vol.116
, pp. 5686-5693
-
-
Dy, G.K.1
Hillman, S.L.2
Rowland Jr., K.M.3
-
21
-
-
34548077118
-
Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors
-
DOI 10.1158/1078-0432.CCR-07-0382
-
Duran I, Hotte SJ, Hirte H, et al. Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors. Clin Cancer Res 2007; 13:4849-57. (Pubitemid 47294792)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.16
, pp. 4849-4857
-
-
Duran, I.1
Hotte, S.J.2
Hirte, H.3
Chen, E.X.4
MacLean, M.5
Turner, S.6
Duan, L.7
Pond, G.R.8
Lathia, C.9
Walsh, S.10
Wright, J.J.11
Dancey, J.12
Siu, L.L.13
-
22
-
-
34250168681
-
Phase I trial of sorafenib in combination with IFN α-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma
-
DOI 10.1158/1078-0432.CCR-06-1432
-
Escudier B, Lassau N, Angevin E, et al. Phase I trial of sorafenib in combination with IFN alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma. Clin Cancer Res 2007; 13:1801-9. (Pubitemid 46952949)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.6
, pp. 1801-1809
-
-
Escudier, B.1
Lassau, N.2
Angevin, E.3
Soria, J.C.4
Chami, L.5
Lamuraglia, M.6
Zafarana, E.7
Landreau, V.8
Schwartz, B.9
Brendel, E.10
Armand, J.-P.11
Robert, C.12
-
23
-
-
70349304196
-
Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
-
Blumenschein GR Jr, Gatzemeier U, Fossella F, et al. Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer. J Clin Oncol 2009; 27:4274-80.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4274-4280
-
-
Blumenschein Jr., G.R.1
Gatzemeier, U.2
Fossella, F.3
-
24
-
-
33845321649
-
A Phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC)
-
Abstract 17119
-
Liu B, Barrett T, Choyke P, et al. A Phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC). J Clin Oncol 2006; 24(Suppl):676S Abstract 17119.
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL.
-
-
Liu, B.1
Barrett, T.2
Choyke, P.3
-
25
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
DOI 10.1056/NEJMoa060655
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356:125-34. (Pubitemid 46089673)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
26
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359:378-90.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
27
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomized, double-blind, placebo-controlled trial
-
Cheng A-L, Kang TK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomized, double-blind, placebo-controlled trial. Lancet Oncol 2009; 10:25-34.
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.-L.1
Kang, T.K.2
Chen, Z.3
-
28
-
-
77951639655
-
Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
-
Scagliotti G, Novello S, von Pawel J, et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 2010; 28:1835-42.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1835-1842
-
-
Scagliotti, G.1
Novello, S.2
Von Pawel, J.3
-
29
-
-
79960381436
-
A randomized discontinuation phase II study of sorafenib vs placebo in patients with non-small cell lung cancer (NSCLC) who failed at least two prior chemotherapy regimens: E2501
-
San Francisco, CA: July 31-August 4 Abstract C1.6
-
Schiller J, Lee J-W, Hanna NH, et al. A randomized discontinuation phase II study of sorafenib vs placebo in patients with non-small cell lung cancer (NSCLC) who failed at least two prior chemotherapy regimens: E2501. International Association for the Study of Lung Cancer 13th World Conference on Lung Cancer. San Francisco, CA: July 31-August 4, 2009 Abstract C1.6.
-
(2009)
International Association for the Study of Lung Cancer 13th World Conference on Lung Cancer
-
-
Schiller, J.1
Lee, J.-W.2
Hanna, N.H.3
-
30
-
-
33244473530
-
Comprehensive symptom management in patients with advanced-stage non-small-cell lung cancer
-
Temel JS, Pirl WF, Lynch TJ. Comprehensive symptom management in patients with advanced-stage non-small-cell lung cancer. Clin Lung Cancer 2006; 7:241-9. (Pubitemid 43280026)
-
(2006)
Clinical Lung Cancer
, vol.7
, Issue.4
, pp. 241-249
-
-
Temel, J.S.1
Pirl, W.F.2
Lynch, T.J.3
-
31
-
-
73349100990
-
Sorafenib-related hand-foot skin reaction improves, not worsens, with continued treatment
-
Flaherty KT, Brose MS. Sorafenib-related hand-foot skin reaction improves, not worsens, with continued treatment. Clin Cancer Res 2009; 15:7749.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7749
-
-
Flaherty, K.T.1
Brose, M.S.2
-
32
-
-
56249109644
-
Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomized phase III trial
-
Kim ES, Hirsh V, Mok T, et al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomized phase III trial. Lancet 2008; 372:1809-18.
-
(2008)
Lancet
, vol.372
, pp. 1809-1818
-
-
Kim, E.S.1
Hirsh, V.2
Mok, T.3
-
33
-
-
38449101219
-
Sorafenib: A promising new targeted therapy for renal cell carcinoma
-
Wood LS, Manchen B. Sorafenib: a promising new targeted therapy for renal cell carcinoma. Clin J Oncol Nurs 2007; 11:649-56.
-
(2007)
Clin J Oncol Nurs
, vol.11
, pp. 649-656
-
-
Wood, L.S.1
Manchen, B.2
-
34
-
-
34648813908
-
Managing side effects of angiogenesis inhibitors in renal cell carcinoma
-
DOI 10.1159/000107721
-
Grünwald V, Heinzer H, Fiedler W. Managing side effects of angiogenesis inhibitors in renal cell carcinoma. Onkologie 2007; 30:519-24. (Pubitemid 47462063)
-
(2007)
Onkologie
, vol.30
, Issue.10
, pp. 519-524
-
-
Grunwald, V.1
Heinzer, H.2
Fiedler, W.3
-
35
-
-
42049101034
-
Systemic treatment for advanced (stage IIIb/IV) non-small cell lung cancer: More treatment options; More things to consider
-
Bunn PA, Thatcher N. Systemic treatment for advanced (stage IIIb/IV) non-small cell lung cancer: more treatment options; more things to consider. Conclusion. Oncologist 2008; 13(Suppl 1):37-46.
-
(2008)
Conclusion. Oncologist
, vol.13
, Issue.SUPPL. 1
, pp. 37-46
-
-
Bunn, P.A.1
Thatcher, N.2
|