-
1
-
-
44349124113
-
The genetics and immunopathogenesis of inflammatory bowel disease
-
DOI 10.1038/nri2340, PII NRI2340
-
J.H. Cho, The genetics and immunopathogenesis of inflammatory bowel disease, Nat Rev Immunol 8 (2008), 458-466. (Pubitemid 351733422)
-
(2008)
Nature Reviews Immunology
, vol.8
, Issue.6
, pp. 458-466
-
-
Cho, J.H.1
-
2
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
WTCCC
-
WTCCC, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447 (2007), 661-678.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
3
-
-
34347338690
-
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
-
DOI 10.1038/ng2061, PII NG2061
-
M. Parkes, J.C. Barrett, N.J. Prescott, M. Tremelling, C.A. Anderson, S.A. Fisher, R.G. Roberts, E.R. Nimmo, F.R. Cum-mings, D. Soars, H. Drummond, C.W. Lees, S.A. Khawaja, R. Bagnall, D.A. Burke, C.E. Todhunter, T. Ahmad, C.M. Onnie, W. McArdle, D. Strachan, G. Bethel, C. Bryan, C.M. Lewis, P. Deloukas, A. Forbes, J. Sanderson, D.P. Jewell, J. Satsangi, J.C. Mansfield, L. Cardon and C.G. Mathew, Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility, Nat Genet 39 (2007), 830-832. (Pubitemid 47014496)
-
(2007)
Nature Genetics
, vol.39
, Issue.7
, pp. 830-832
-
-
Parkes, M.1
Barrett, J.C.2
Prescott, N.J.3
Tremelling, M.4
Anderson, C.A.5
Fisher, S.A.6
Roberts, R.G.7
Nimmo, E.R.8
Cummings, F.R.9
Soars, D.10
Drummond, H.11
Lees, C.W.12
Khawaja, S.A.13
Bagnall, R.14
Burke, D.A.15
Todhunter, C.E.16
Ahmad, T.17
Onnie, C.M.18
McArdle, W.19
Strachan, D.20
Bethel, G.21
Bryan, C.22
Lewis, C.M.23
Deloukas, P.24
Forbes, A.25
Sanderson, J.26
Jewell, D.P.27
Satsangi, J.28
Mansfield, J.C.29
Cardon, L.30
Mathew, C.G.31
more..
-
4
-
-
44349173654
-
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
-
DOI 10.1038/ng.148, PII NG148
-
A. Franke, T. Balschun, T.H. Karlsen, J. Hedderich, S. May, T. Lu, D. Schuldt, S. Nikolaus, P. Rosenstiel, M. Krawczak and S. Schreiber, Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis, Nat Genet 40 (2008), 713-715. (Pubitemid 351748866)
-
(2008)
Nature Genetics
, vol.40
, Issue.6
, pp. 713-715
-
-
Franke, A.1
Balschun, T.2
Karlsen, T.H.3
Hedderich, J.4
May, S.5
Lu, T.6
Schuldt, D.7
Nikolaus, S.8
Rosenstiel, P.9
Krawczak, M.10
Schreiber, S.11
-
5
-
-
62049085384
-
Confirmation of multiple crohn's disease susceptibility loci in a large dutch-belgian cohort
-
R.K. Weersma, P.C. Stokkers, I. Cleynen, S.C. Wolfkamp, L. Henckaerts, S. Schreiber, G. Dijkstra, A. Franke, I.M. Nolte, P. Rutgeerts, C. Wijmenga and S. Vermeire, Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort, Am J Gastroenterol 104 (2009), 630-638.
-
(2009)
Am J Gastroenterol
, vol.104
, pp. 630-638
-
-
Weersma, R.K.1
Stokkers, P.C.2
Cleynen, I.3
Wolfkamp, S.C.4
Henckaerts, L.5
Schreiber, S.6
Dijkstra, G.7
Franke, A.8
Nolte, I.M.9
Rutgeerts, P.10
Wijmenga, C.11
Vermeire, S.12
-
6
-
-
0035313868
-
Combinatorial control of the specificity of protein tyrosine phosphatases
-
DOI 10.1016/S0955-0674(00)00196-4
-
N.K. Tonks and B.G. Neel, Combinatorial control of the specificity of protein tyrosine phosphatases, Curr Opin Cell Biol 13 (2001), 182-195. (Pubitemid 32209219)
-
(2001)
Current Opinion in Cell Biology
, vol.13
, Issue.2
, pp. 182-195
-
-
Tonks, N.K.1
Neel, B.G.2
-
7
-
-
1942489307
-
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease
-
DOI 10.1182/blood-2003-09-3153
-
K.M. Heinonen, F.P. Nestel, E.W. Newell, G. Charette, T.A. Seemayer, M.L. Tremblay and W.S. Lapp, T-cell protein ty-rosine phosphatase deletion results in progressive systemic inflammatory disease, Blood 103 (2004), 3457-3464. (Pubitemid 38525678)
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3457-3464
-
-
Heinonen, K.M.1
Nestel, F.P.2
Newell, E.W.3
Charette, G.4
Seemayer, T.A.5
Tremblay, M.L.6
Lapp, W.S.7
-
8
-
-
78651070199
-
Protein tyrosine phosphatase N2 regulates tnfalpha-induced signalling and cytokine secretion in human intestinal epithelial cells
-
M. Scharl, D.F. McCole, A. Weber, S.R. Vavricka, P. Frei, S. Kellermeier, T. Pesch, M. Fried and G. Rogler, Protein tyrosine phosphatase N2 regulates TNFalpha-induced signalling and cytokine secretion in human intestinal epithelial cells, Gut 60 (2011), 189-197.
-
(2011)
Gut
, vol.60
, pp. 189-197
-
-
Scharl, M.1
McCole, D.F.2
Weber, A.3
Vavricka, S.R.4
Frei, P.5
Kellermeier, S.6
Pesch, T.7
Fried, M.8
Rogler, G.9
-
9
-
-
70649104669
-
Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2
-
M. Scharl, G. Paul, A. Weber, B.C. Jung, M.J. Docherty, M. Hausmann, G. Rogler, K.E. Barrett and D.F. McCole, Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2, Gastroenterology 137 (2009), 2030-2040 e5.
-
(2009)
Gastroenterology
, vol.137
-
-
Scharl, M.1
Paul, G.2
Weber, A.3
Jung, B.C.4
Docherty, M.J.5
Hausmann, M.6
Rogler, G.7
Barrett, K.E.8
McCole, D.F.9
-
10
-
-
67651085303
-
Association of a nkx2-3 polymorphism with crohn's disease and expression of nkx2-3 is up-regulated in B cell lines and intestinal tissues with crohn's disease
-
W. Yu, Z. Lin, A.A. Kelly, J.P. Hegarty, L.S. Poritz, Y. Wang, T. Li, S. Schreiber and W.A. Koltun, Association of a Nkx2-3 polymorphism with Crohn's disease and expression of Nkx2-3 is up-regulated in B cell lines and intestinal tissues with Crohn's disease, Journal of Crohn's and Colitis 3 (2009), 189-195.
-
(2009)
Journal of Crohn's and Colitis
, vol.3
, pp. 189-195
-
-
Yu, W.1
Lin, Z.2
Kelly, A.A.3
Hegarty, J.P.4
Poritz, L.S.5
Wang, Y.6
Li, T.7
Schreiber, S.8
Koltun, W.A.9
-
11
-
-
77950519925
-
Genes regulated by nkx2-3 in sirna-mediated knockdown B cells: Implication of endothelin-1 in inflammatory bowel disease
-
W. Yu, Z. Lin, J.P. Hegarty, G. John, X. Chen, P.W. Faber, A.A. Kelly, Y. Wang, L.S. Poritz, S. Schreiber and W.A. Koltun, Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel disease, Mol Genet Metab 100 (2010), 88-95.
-
(2010)
Mol Genet Metab
, vol.100
, pp. 88-95
-
-
Yu, W.1
Lin, Z.2
Hegarty, J.P.3
John, G.4
Chen, X.5
Faber, P.W.6
Kelly, A.A.7
Wang, Y.8
Poritz, L.S.9
Schreiber, S.10
Koltun, W.A.11
-
12
-
-
84863789923
-
Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1
-
(accepted, in press)
-
W. Yu, Z. Lin, J.P. Hegarty, X. Chen, A.A. Kelly, Y. Wang, L.S. Poritz and W.A. Koltun, Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1, Inflammation (2011), (accepted, in press).
-
(2011)
Inflammation
-
-
Yu, W.1
Lin, Z.2
Hegarty, J.P.3
Chen, X.4
Kelly, A.A.5
Wang, Y.6
Poritz, L.S.7
Koltun, W.A.8
-
13
-
-
79957541726
-
Nkx2-3 tran-scriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells
-
W. Yu, J.P. Hegarty, A. Berg, X. Chen, G. West, A.A. Kelly, Y. Wang, L.S. Poritz, W.A. Koltun and Z. Lin, NKX2-3 Tran-scriptional Regulation of Endothelin-1 and VEGF Signaling in Human Intestinal Microvascular Endothelial Cells, PLoS One 6 (2011), e20454.
-
(2011)
PLoS One
, vol.6
-
-
Yu, W.1
Hegarty, J.P.2
Berg, A.3
Chen, X.4
West, G.5
Kelly, A.A.6
Wang, Y.7
Poritz, L.S.8
Koltun, W.A.9
Lin, Z.10
-
14
-
-
80052536374
-
Nkx2-3 variant rs11190140 is associated with IBD and alters binding of nfat
-
G. John, J.P. Hegarty, W. Yu, A. Berg, D.M. Pastor, A.A. Kelly, Y. Wang, L.S. Poritz, S. Schreiber, W.A. Koltun and Z. Lin, NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT, Mol Genet Metab 104 (2011), 174-179.
-
(2011)
Mol Genet Metab
, vol.104
, pp. 174-179
-
-
John, G.1
Hegarty, J.P.2
Yu, W.3
Berg, A.4
Pastor, D.M.5
Kelly, A.A.6
Wang, Y.7
Poritz, L.S.8
Schreiber, S.9
Koltun, W.A.10
Lin, Z.11
-
15
-
-
80051566281
-
Genetic variants and monoallelic expression of surfactant protein-d in inflammatory bowel disease
-
Z. Lin, G. John, J.P. Hegarty, A. Berg, W. Yu, Y. Wang, A.A. Kelly, B.Z. Peterson, L.S. Poritz, J. Floros and W.A. Koltun, Genetic Variants and Monoallelic Expression of Surfactant Protein-D in Inflammatory Bowel Disease, Ann Hum Genet 75 (2011), 559-568.
-
(2011)
Ann Hum Genet
, vol.75
, pp. 559-568
-
-
Lin, Z.1
John, G.2
Hegarty, J.P.3
Berg, A.4
Yu, W.5
Wang, Y.6
Kelly, A.A.7
Peterson, B.Z.8
Poritz, L.S.9
Floros, J.10
Koltun, W.A.11
-
16
-
-
78149359520
-
Genes Regulated by Nkx2-3 in Sporadic and Inflammatory Bowel Disease-Associated Colorectal Cancer Cell Lines
-
W. Yu, Z. Lin, D.M. Pastor, J.P. Hegarty, X. Chen, A.A. Kelly, Y. Wang, L.S. Poritz and W.A. Koltun, Genes Regulated by Nkx2-3 in Sporadic and Inflammatory Bowel Disease-Associated Colorectal Cancer Cell Lines, Dig Dis Sci 55 (2010), 3171-3180.
-
(2010)
Dig Dis Sci
, vol.55
, pp. 3171-3180
-
-
Yu, W.1
Lin, Z.2
Pastor, D.M.3
Hegarty, J.P.4
Chen, X.5
Kelly, A.A.6
Wang, Y.7
Poritz, L.S.8
Koltun, W.A.9
-
17
-
-
61849135255
-
T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: Lessons from the knockout mouse model and implications in human disease
-
K.M. Doody, A. Bourdeau and M.L. Tremblay, T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease, Immunol Rev 228 (2009), 325-341.
-
(2009)
Immunol Rev
, vol.228
, pp. 325-341
-
-
Doody, K.M.1
Bourdeau, A.2
Tremblay, M.L.3
-
18
-
-
0037299902
-
Upregulation of interleukin-12 and -17 in active inflammatory bowel disease
-
DOI 10.1080/00365520310000672
-
O.H. Nielsen, I. Kirman, N. Rudiger, J. Hendel and B. Vainer, Upregulation of interleukin-12 and-17 in active inflammatory bowel disease, Scand J Gastroenterol 38 (2003), 180-185. (Pubitemid 36349930)
-
(2003)
Scandinavian Journal of Gastroenterology
, vol.38
, Issue.2
, pp. 180-185
-
-
Nielsen, O.H.1
Kirman, I.2
Rudiger, N.3
Hendel, J.4
Vainer, B.5
-
19
-
-
34250675278
-
Current and future anti-TNF therapy for inflammatory bowel disease
-
DOI 10.1007/s11938-007-0013-3
-
M.T. Osterman and G.R. Lichtenstein, Current and Future Anti-TNF Therapy for Inflammatory Bowel Disease, Curr Treat Options Gastroenterol 10 (2007), 195-207. (Pubitemid 46938929)
-
(2007)
Current Treatment Options in Gastroenterology
, vol.10
, Issue.3
, pp. 195-207
-
-
Osterman, M.T.1
Lichtenstein, G.R.2
-
20
-
-
31144445210
-
Inflammatory bowel disease requires the interplay between innate and adaptive immune signals
-
DOI 10.1038/sj.cr.7310009, PII 7310009
-
D. Shi, J. Das and G. Das, Inflammatory boweldisease requires the interplay between innate and adaptive immune signals, Cell Res 16 (2006), 70-74. (Pubitemid 43129310)
-
(2006)
Cell Research
, vol.16
, Issue.1
, pp. 70-74
-
-
Shi, D.1
Das, J.2
Das, G.3
-
21
-
-
0037769202
-
+ myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-γ- and nitric oxide-dependent mechanism
-
M. Dupuis, M. De Jesus Ibarra-Sanchez, M.L. Tremblay and P. Duplay, Gr-1+ myeloid cells lacking T cell protein tyro-sine phosphatase inhibit lymphocyte proliferation by an IFN-gamma-and nitric oxide-dependent mechanism, J Immunol 171 (2003), 726-732. (Pubitemid 36871382)
-
(2003)
Journal of Immunology
, vol.171
, Issue.2
, pp. 726-732
-
-
Dupuis, M.1
Ibarra-Sanchez, M.D.J.2
Tremblay, M.L.3
Duplay, P.4
-
22
-
-
34248334251
-
TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-γ
-
DOI 10.1182/blood-2006-08-044370
-
A. Bourdeau, N. Dube, K.M. Heinonen, J.F. Theberge, K.M. Doody and M.L. Tremblay, TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}, Blood 109 (2007), 4220-4228. (Pubitemid 46743386)
-
(2007)
Blood
, vol.109
, Issue.10
, pp. 4220-4228
-
-
Bourdeau, A.1
Dube, N.2
Heinonen, K.M.3
Theberge, J.-F.4
Doody, K.M.5
Tremblay, M.L.6
-
23
-
-
0031647381
-
Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner
-
Y. Fu, W. Yan, T.J. Mohun and S.M. Evans, Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner, Development 125 (1998), 4439-4449. (Pubitemid 28564288)
-
(1998)
Development
, vol.125
, Issue.22
, pp. 4439-4449
-
-
Fu, Y.1
Yan, W.2
Mohun, T.J.3
Evans, S.M.4
-
24
-
-
0030899175
-
The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development
-
O. Pabst, A. Schneider, T. Brand and H.H. Arnold, The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre-and postnatal mouse development, Dev Dyn 209 (1997), 29-35. (Pubitemid 27188336)
-
(1997)
Developmental Dynamics
, vol.209
, Issue.1
, pp. 29-35
-
-
Pabst, O.1
Schneider, A.2
Brand, T.3
Arnold, H.-H.4
-
25
-
-
0037446534
-
Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses
-
D. Tarlinton, A. Light, D. Metcalf, R.P. Harvey and L. Robb, Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses, J Immunol 170 (2003), 4002-4010. (Pubitemid 36428161)
-
(2003)
Journal of Immunology
, vol.170
, Issue.8
, pp. 4002-4010
-
-
Tarlinton, D.1
Light, A.2
Metcalf, D.3
Harvey, R.P.4
Robb, L.5
|