Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampus

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Castellano, James F ^a,b   Fletcher, Bonnie R ^a   Kelley Bell, Bennett ^a   Kim, David H ^a   Gallagher, Michela ^c   Rapp, Peter R ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT ANIMAL; AGE DISTRIBUTION; AGED; AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN; COGNITIVE DEFECT; CONTROLLED STUDY; EPIGENETICS; GENE EXPRESSION; GENETIC ASSOCIATION; HIPPOCAMPUS; MALE; MEMORY DISORDER; MULTIVARIATE ANALYSIS; NONHUMAN; RAT; SPATIAL MEMORY; TRANSLATIONAL RESEARCH; ACETYLATION; ANIMAL; BEHAVIOR; DISEASE MODEL; GENETIC EPIGENESIS; GENETICS; LONG EVANS RAT; MAZE TEST; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; PSYCHOLOGICAL ASPECT;

RATTUS;

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; HDAC1 PROTEIN, RAT; HISTONE; HISTONE DEACETYLASE 1;

ACETYLATION; AGING; ANIMALS; CREB-BINDING PROTEIN; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; HIPPOCAMPUS; HISTONE DEACETYLASE 1; HISTONES; MALE; MAZE LEARNING; MEMORY DISORDERS; MULTIVARIATE ANALYSIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, LONG-EVANS; SPATIAL BEHAVIOR; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84863281305     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033249     Document Type: Article

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