Intracellular interferon-γ staining analysis of donor-specific t-cell responses in liver transplant recipients

Transplantation Proceedings

Volumn 44, Issue 2, 2012, Pages 548-554

  Okanami, Y ^a,b,c   Tsujimura, K ^b,d   Mizuno, S ^a   Tabata, M ^a   Isaji, S ^a   Akatsuka, Y ^b   Kuzushima, K ^b   Takahashi, T ^b   Uemoto, S ^e  

^a MIE UNIVERSITY   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; GAMMA INTERFERON; METHYLPREDNISOLONE; PREDNISOLONE; TACROLIMUS;

ADOLESCENT; ADULT; AGED; ALLOIMMUNITY; ARTICLE; B LYMPHOCYTE ACTIVATION; BILE DUCT ATRESIA; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; HEPATITIS A; HEPATITIS B; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LYMPHOCYTE CULTURE; MALE; ORGAN DONOR; PERIPHERAL BLOOD MONONUCLEAR CELL; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; STAINING;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD40; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; HUMANS; INTERFERON-GAMMA; JAPAN; LIVER TRANSPLANTATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84863275042     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2011.11.007     Document Type: Article

References (32)

1. M.H. Sayegh, C.B. Carpenter Transplantation 50 years later: progress, challenges, and promises N Engl J Med 351 2004 2761
2. M. Toungouz, V. Donckier, M. Goldman Tolerance induction in clinical transplantation: the pending questions Transplantation 75 2003 58S
3. R. Reding, J. Gras, D.Q. Truong The immunological monitoring of alloreactive responses in liver transplant recipients: a review Liver Transpl 12 2006 373
4. J. Levitsky Operational tolerance: past lessons and future prospects Liver Transpl 17 2011 222
5. S. Heidt, D. San Segundo, S. Shankar Peripheral blood sampling for the detection of allograft rejection: biomarker identification and validation Transplantation 92 2011 1
6. + T-cell differentiation regulated by networks of cytokines and transcription factors Immunol Rev 238 2010 247
7. + regulatory T cells in the human immune system Nat Rev Immunol 10 2010 490
8. + T cell subsets; differences between naive and antigen specific T regulatory cells Curr Opin Immunol 23 2011 641
9. + Treg-mediated suppression Trends Immunol 29 2008 337
10. J.L. Schultze, S. Michalak, M.J. Seamon CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy J Clin Invest 100 1997 2757
11. E. Kondo, M.S. Topp, H.P. Kiem Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells J Immunol 169 2002 2164
12. A.J. Demetris, K.P. Batts, A.P. Dhillon Banff schema for grading liver allograft rejection: an international consensus document Hepatology 25 1997 658
13. E. Kondo, Y. Akatsuka, K. Kuzushima Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles Blood 103 2004 630
14. O. Lantz, P. Alard, M.H. Ben Aribia Persistence of donor-specific IL-2-secreting cells and cytotoxic T lymphocyte precursors in human kidney transplant recipients evidenced by limiting dilution analysis J Immunol 144 1990 3748
15. E. van Twuyver, J. de Hoop, R.J. ten Berge Comparison of T cell responses in patients with a long-term surviving renal allograft versus a long-term surviving liver allograft It's a different world Transplantation 61 1996 1392
16. P.S. Heeger, N.S. Greenspan, S. Kuhlenschmidt Pretransplant frequency of donor-specific, IFN-γ-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes J Immunol 163 1999 2267
17. M. Takatsuki, S. Uemoto, Y. Inomata Analysis of alloreactivity and intragraft cytokine profiles in living donor liver transplant recipients with graft acceptance Transpl Immunol 8 2001 279
18. F. Geissler, E. Jankowska-Gan, L.D. DeVito-Haynes Human liver allograft acceptance and the "tolerance assay": in vitro anti-donor T cell assays show hyporeactivity to donor cells, but unlike DTH, fail to detect linked suppression Transplantation 72 2001 571
19. A. De Haan, I. Van Der Gun, W. Van Der Bij Detection of alloreactive T cells by flow cytometry: a new test compared with limiting dilution assay Transplantation 74 2002 562
20. S. Romagnani The Th1/Th2 paradigm Immunol Today 18 1997 263
21. T.B. Strom, P. Roy-Chaudhury, R. Manfro The Th1/Th2 paradigm and the allograft response Curr Opin Immunol 8 1996 688
22. X.C. Li, M.S. Zand, Y. Li On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses J Immunol 161 1998 2241
23. K.J. Wood, S. Sakaguchi Regulatory T cells in transplantation tolerance Nat Rev Immunol 3 2003 199
24. C.T. Weaver, R.D. Hatton, P.R. Mangan IL-17 family cytokines and the expanding diversity of effector T cell lineages Annu Rev Immunol 25 2007 821
25. A. Sanchez-Fueyo, T.B. Strom Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs Gastroenterology 140 2011 51
26. + T-cell frequencies by flow cytometry Blood 94 1999 3094
27. S. Gottschalk, C.M. Rooney, H.E. Heslop Post-transplant lymphoproliferative disorders Annu Rev Med 56 2005 29
28. J.I. Cohen Epstein-Barr virus infection N Engl J Med 343 2000 481
29. K.J. Wood, A. Bushell, N.D. Jones Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells Immunol Rev 241 2011 119
30. X.C. Li, L.A. Turka An update on regulatory T cells in transplant tolerance and rejection Nat Rev Nephrol 6 2010 577
31. Y. Li, X. Zhao, D. Cheng The presence of Foxp3 expressing T cells within grafts of tolerant human liver transplant recipients Transplantation 86 2008 1837
32. H. Nafady-Hego, Y. Li, H. Ohe The generation of donor-specific CD4+CD25++CD45RA+ naive regulatory T cells in operationally tolerant patients after pediatric living-donor liver transplantation Transplantation 90 2010 1547