Effects of the pro-inflammatory milieu on the dedifferentiation of cultured fibroblast-like synoviocytes

Molecular Medicine Reports

Volumn 5, Issue 4, 2012, Pages 1023-1026

  Choi, Hong Seo ^a   Ryu, Chun Jeih ^a   Choi, Hyun Mi ^b   Park, Jin Sung ^c   Lee, Jae Hoon ^b   Kim, Kang Il ^b   Yang, Hyung In ^b   Yoo, Myung Chul ^b   Kim, Kyoung Soo ^b  

^a Sejong University   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

^c Ajou University School of Medicine   (South Korea)

Author keywords

Bone marrow mesenchymal stem cell; Dedifferentiation; Dermis; Fibroblast like synoviocytes; Osteoarthritis; Rheumatoid arthritis; Stem cell markers

Indexed keywords

BIOLOGICAL MARKER; CD146 ANTIGEN; CYTOKINE; HERMES ANTIGEN; PROTEIN; PROTEIN STRO 1; THY 1 ANTIGEN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANTIGEN EXPRESSION; ARTICLE; CELL DEDIFFERENTIATION; CELL HYPOXIA; CELL TYPE; CONTROLLED STUDY; FIBROBLAST; FLUORESCENCE ACTIVATED CELL SORTING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INFLAMMATION; MESENCHYMAL STEM CELL; OSTEOARTHRITIS; PHENOTYPE; RHEUMATOID ARTHRITIS; SKIN FIBROBLAST; SYNOVIOCYTE; SYNOVIOCYTE LIKE SYNOVIOCYTE; TUMOR GROWTH;

ANTIGENS, CD146; ANTIGENS, CD44; ANTIGENS, THY-1; ARTHRITIS, RHEUMATOID; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL HYPOXIA; CELLS, CULTURED; CYTOKINES; FIBROBLASTS; HUMANS; INTERLEUKIN-1BETA; MESENCHYMAL STEM CELLS; OSTEOARTHRITIS; SYNOVIAL MEMBRANE;

EID: 84863268241     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.767     Document Type: Article

References (28)

1. Firestein GS: Evolving concepts of rheumatoid arthritis. Nature 423: 356-361, 2003.
2. Pap T, Muller-Ladner U, Gay RE and Gay S: Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2: 361-367, 2000. (Pubitemid 32223765)
3. Edwards JC: Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis. Arthritis Res 2: 344-347, 2000.
4. Firestein GS: Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum 39: 1781-1790, 1996.
5. Muller-Ladner U, Kriegsmann J, Gay RE and Gay S: Oncogenes in rheumatoid arthritis. Rheum Dis Clin North Am 21: 675-690, 1995.
6. Yamanishi Y, Boyle DL, Rosengren S, Green DR, Zvaifler NJ and Firestein GS: Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc Natl Acad Sci USA 99: 10025-10030, 2002. (Pubitemid 34831166)
7. Lafyatis R, Remmers EF, Roberts AB, Yocum DE, Sporn MB and Wilder RL: Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J Clin Invest 83: 1267-1276, 1989. (Pubitemid 19113041)
8. Yamasaki S, Nakashima T, Kawakami A, et al: Cytokines regulate fibroblast-like synovial cell differentiation to adipocyte-like cells. Rheumatology (Oxford) 43: 448-452, 2004. (Pubitemid 38489361)
9. Zvaifler NJ, Tsai V, Alsalameh S, von Kempis J, Firestein GS and Lotz M: Pannocytes: distinctive cells found in rheumatoid arthritis articular cartilage erosions. Am J Pathol 150: 1125-1138, 1997. (Pubitemid 27106181)
10. Nakagawa S, Toritsuka Y, Wakitani S, et al: Bone marrow stromal cells contribute to synovial cell proliferation in rats with collagen induced arthritis. J Rheumatol 23: 2098-2103, 1996. (Pubitemid 27006757)
11. Marinova-Mutafchieva L, Williams RO, Funa K, Maini RN and Zvaifler NJ: Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis. Arthritis Rheum 46: 507-513, 2002. (Pubitemid 34136589)
12. Murakami S, Lefebvre V and de Crombrugghe B: Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha. J Biol Chem 275: 3687-3692, 2000. (Pubitemid 30083081)
13. Gilbert L, He X, Farmer P, et al: Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem 277: 2695-2701, 2002. (Pubitemid 34953297)
14. Li X and Makarov SS: An essential role of NF-kappaB in the 'tumor-like' phenotype of arthritic synoviocytes. Proc Natl Acad Sci USA 103: 17432-17437, 2006. (Pubitemid 44788986)
15. Wehling N, Palmer GD, Pilapil C, et al: Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathways. Arthritis Rheum 60: 801-812, 2009.
16. Duval E, Leclercq S, Elissalde JM, Demoor M, Galera P and Boumediene K: Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes. Arthritis Rheum 60: 3038-3048, 2009.
17. Javazon EH, Colter DC, Schwarz EJ and Prockop DJ: Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells. Stem Cells 19: 219-225, 2001. (Pubitemid 32524543)
18. Eslaminejad MB, Nikmahzar A, Taghiyar L, Nadri S and Massumi M: Murine mesenchymal stem cells isolated by low density primary culture system. Dev Growth Differ 48: 361-370, 2006. (Pubitemid 44035794)
19. Docheva D, Popov C, Mutschler W and Schieker M: Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system. J Cell Mol Med 11: 21-38, 2007. (Pubitemid 46439623)
20. Pittenger MF, Mackay AM, Beck SC, et al: Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147, 1999. (Pubitemid 29282067)
21. Steinert AF, Kunz M, Prager P, et al: Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Eng Part A 17: 1375-1388, 2011.
22. Yang JW, de Isla N, Huselstein C, et al: Evaluation of human MSCs cell cycle, viability and differentiation in micromass culture. Biorheology 43: 489-496, 2006. (Pubitemid 44221928)
23. Wiesmann A, Buhring HJ, Mentrup C and Wiesmann HP: Decreased CD90 expression in human mesenchymal stem cells by applying mechanical stimulation. Head Face Med 2: 8, 2006.
24. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM and Silberstein LE: Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells 24: 1030-1041, 2006. (Pubitemid 44464736)
25. Halfon S, Abramov N, Grinblat B and Ginis I: Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging. Stem Cells Dev 20: 53-66, 2011.
26. Lee HJ, Choi BH, Min BH and Park SR: Changes in surface markers of human mesenchymal stem cells during the chondrogenic differentiation and dedifferentiation processes in vitro. Arthritis Rheum 60: 2325-2332, 2009.
27. Digirolamo CM, Stokes D, Colter D, Phinney DG, Class R and Prockop DJ: Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol 107: 275-281, 1999. (Pubitemid 29530211)
28. Sekiya I, Colter DC and Prockop DJ: BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun 284: 411-418, 2001. (Pubitemid 32917992)