Correlation of the phenotypic ethambutol susceptibility of Mycobacterium tuberculosis with embB gene mutations in Korea

Journal of Medical Microbiology

Volumn 61, Issue 4, 2012, Pages 529-534

  Park, Young Kil ^a   Ryoo, Sung Weon ^a   Lee, Seung Heon ^a   Jnawali, Hum Nath ^a   Kim, Chang Ki ^a   Kim, Hee Jin ^a   Kim, Sang Jae ^a  

^a Korean Institute of Tuberculosis   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ETHAMBUTOL;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CODON; EMBB GENE; GENE; GENE MUTATION; HUMAN; KOREA; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; WILD TYPE;

ANTITUBERCULAR AGENTS; DRUG RESISTANCE, BACTERIAL; ETHAMBUTOL; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PENTOSYLTRANSFERASES; REPUBLIC OF KOREA; TUBERCULOSIS, MULTIDRUG-RESISTANT; TUBERCULOSIS, PULMONARY;

EID: 84863268017     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.037614-0     Document Type: Article

References (32)

1. Alcaide, F., Pfyffer, G. E. & Telenti, A. (1997). Role of embB in natural and acquired resistance to ethambutol in mycobacteria. Antimicrob Agents Chemother 41, 2270-2273.
2. Canetti, G., Fox, W., Khomenko, A., Mahler, H. T., Menon, N. K., Mitchison, D. A., Rist, N. & Smelev, N. A. (1969). Advances in techniques of testing mycobacterial drug sensitivity, and the use of sensitivity tests in tuberculosis control programmes. Bull World Health Organ 41, 21-43.
3. CDC (2006). Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs worldwide, 2000-2004. MMWR Morb Mortal Wkly Rep 55, 301-305.
4. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S. & other authors (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544.
5. Hazbón, M. H., Bobadilla del Valle, M., Guerrero, M. I., Varma-Basil, M., Filliol, I., Cavatore, M., Colangeli, R., Safi, H., Billman-Jacobe, H. & other authors (2005). Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance. Antimicrob Agents Chemother 49, 3794-3802.
6. Kemper, C. A., Havlir, D., Haghighat, D., Dubé, M., Bartok, A. E., Sison, J. P., Yao, Y., Yangco, B., Leedom, J. M. & other authors (1994). The individual microbiologic effect of three antimycobacterial agents, clofazimine, ethambutol, and rifampin, on Mycobacterium avium complex bacteremia in patients with AIDS. J Infect Dis 170, 157-164.
7. Kim, S. J. (2005). Drug-susceptibility testing in tuberculosis: methods and reliability of results. Eur Respir J 25, 564-569.
8. Lee, A. S., Othman, S. N., Ho, Y. M. & Wong, S. Y. (2004). Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother 48, 4447-4449.
9. Migliori, G. B., Loddenkemper, R., Blasi, F. & Raviglione, M. C. (2007). 125 years after Robert Koch's discovery of the tubercle bacillus: the new XDR-TB threat. Is "science" enough to tackle the epidemic? Eur Respir J 29, 423-427.
10. Mokrousov, I., Otten, T., Vyshnevskiy, B. & Narvskaya, O. (2002). Detection of embB306 mutations in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis from Northwestern Russia: implications for genotypic resistance testing. J Clin Microbiol 40, 3810-3813.
11. Morris, S., Bai, G. H., Suffys, P., Portillo-Gomez, L., Fairchok, M. & Rouse, D. (1995). Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis. J Infect Dis 171, 954-960.
12. Musser, J. M. (1995). Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin Microbiol Rev 8, 496-514.
13. Park, Y. K., Bai, G. H. & Kim, S. J. (2000). Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from countries in the western pacific region. J Clin Microbiol 38, 191-197.
14. Plinke, C., Rusch-Gerdes, S. & Niemann, S. (2006). Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother 50, 1900-1902.
15. Rabarijaona, L., Boisier, P., Ratsirahonana, O., Razafinimanana, J., Rakotomanana, F., Ratsitorahina, M., Ramarokoto, H., Cauchoix, B. & Aurégan, G. (1999). Replacement of streptomycin by ethambutol in the intensive phase of tuberculosis treatment: no effect on compliance. Int J Tuberc Lung Dis 3, 42-46.
16. Ramaswamy, S. V. & Musser, J. M. (1998). Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis 79, 3-29.
17. Ramaswamy, S. V., Dou, S. J., Rendon, A., Yang, Z., Cave, M. D. & Graviss, E. A. (2004). Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates from Monterrey, Mexico. J Med Microbiol 53, 107-113.
18. Raviglione, M. C. & Smith, I. M. (2007). XDR tuberculosis implications for global public health. N Engl J Med 356, 656-659.
19. Safi, H., Sayers, B., Hazbón, M. H. & Alland, D. (2008). Transfer of embB codon 306 mutations into clinical Mycobacterium tuberculosis strains alters susceptibility to ethambutol, isoniazid, and rifampin. Antimicrob Agents Chemother 52, 2027-2034.
20. Safi, H., Fleischmann, R. D., Peterson, S. N., Jones, M. B., Jarrahi, B. & Alland, D. (2010). Allelic exchange and mutant selection demonstrate that common clinical embCAB gene mutations only modestly increase resistance to ethambutol in Mycobacterium tuberculosis. Antimicrob Agents Chemother 54, 103-108.
21. Sekiguchi, J., Miyoshi-Akiyama, T., Augustynowicz-Kopec ́, E., Zwolska, Z., Kirikae, F., Toyota, E., Kobayashi, I., Morita, K., Kudo, K. & other authors (2007). Detection of multidrug resistance in Mycobacterium tuberculosis. J Clin Microbiol 45, 179-192.
22. Shen, X., Shen, G. M., Wu, J., Gui, X. H., Li, X., Mei, J., DeRiemer, K. & Gao, Q. (2007). Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 51, 2618-2620.
23. Shi, R., Zhang, J., Otomo, K., Zhang, G. & Sugawara, I. (2007). Lack of correlation between embB mutation and ethambutol MIC in Mycobacterium tuberculosis clinical isolates from China. Antimicrob Agents Chemother 51, 4515-4517.
24. Shi, D., Li, L., Zhao, Y., Jia, Q., Li, H., Coulter, C., Jin, Q. & Zhu, G. (2011). Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China. J Antimicrob Chemother 66, 2240-2247.
25. Sreevatsan, S., Stockbauer, K. E., Pan, X., Kreiswirth, B. N., Moghazeh, S. L., Jacobs, W. R., Jr, Telenti, A. & Musser, J. M. (1997). Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations. Antimicrob Agents Chemother 41, 1677-1681.
26. Srivastava, S., Ayyagari, A., Dhole, T. N., Nyati, K. K. & Dwivedi, S. K. (2009). emb nucleotide polymorphisms and the role of embB306 mutations in Mycobacterium tuberculosis resistance to ethambutol. Int J Med Microbiol 299, 269-280.
27. Starks, A. M., Gumusboga, A., Plikaytis, B. B., Shinnick, T. M. & Posey, J. E. (2009). Mutations at embB codon 306 are an important molecular indicator of ethambutol resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 53, 1061-1066.
28. Sugawara, I., Otomo, K., Yamada, H., Wang, G., Du, C., Shi, R. & Zhang, G. (2005). The molecular epidemiology of ethambutol resistant Mycobacterium tuberculosis in Henan Province, China. Jpn J Infect Dis 58, 393-395.
29. Telenti, A., Philipp, W. J., Sreevatsan, S., Bernasconi, C., Stockbauer, K. E., Wieles, B., Musser, J. M. & Jacobs, W. R., Jr (1997). The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol. Nat Med 3, 567-570.
30. Van Rie, A., Warren, R., Mshanga, I., Jordaan, A. M., van der Spuy, G. D., Richardson, M., Simpson, J., Gie, R. P., Enarson, D. A. & other authors (2001). Analysis for a limited number of gene codons can predict drug resistance of Mycobacterium tuberculosis in a high incidence community. J Clin Microbiol 39, 636-641.
31. WHO (1997). Treatment of Tuberculosis. Guidelines for the Management of Drug-resistant Tuberculosis, 2nd edn, pp. 1-47. Geneva: World Health Organization.
32. WHO (2009). Global Tuberculosis Control 2009: Epidemiology Strategy Financing. Report No. WHO/HTM/TB/2009.411, pp. 1-303. Geneva: World Health Organization.