메뉴 건너뛰기




Volumn 13, Issue 2, 2012, Pages 2208-2218

A novel LMP1 antibody synergizes with mitomycin C to inhibit nasopharyngeal carcinoma growth in vivo through inducing apoptosis and downregulating vascular endothelial growth factor

Author keywords

Antibody targeted therapy; Apoptosis; Latent membrane protein 1; Mitomycin C; Nasopharyngeal carcinoma; VEGF

Indexed keywords

ANTINEOPLASTIC AGENT; LATENT MEMBRANE PROTEIN 1; LATENT MEMBRANE PROTEIN 1 ANTIBODY F(AB) FRAGMENT; MITOMYCIN C; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTIBODIES; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; MITOMYCIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VIRAL MATRIX PROTEINS;

EID: 84863262849     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13022208     Document Type: Article
Times cited : (22)

References (30)
  • 1
    • 33750532057 scopus 로고    scopus 로고
    • The enigmatic epidemiology of nasopharyngeal carcinoma
    • Chang, E.T.; Adami, H.O. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol. Biomark. Prev. 2006, 15, 1765-1777.
    • (2006) Cancer Epidemiol. Biomark. Prev , vol.15 , pp. 1765-1777
    • Chang, E.T.1    Adami, H.O.2
  • 2
    • 41949098205 scopus 로고    scopus 로고
    • Advances in nasopharyngeal carcinoma
    • Guigay, J. Advances in nasopharyngeal carcinoma. Curr. Opin. Oncol. 2008, 20, 264-269.
    • (2008) Curr. Opin. Oncol , vol.20 , pp. 264-269
    • Guigay, J.1
  • 3
    • 34548631786 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma: Molecular pathogenesis and therapeutic developments
    • Tao, Q.; Chan, A.T. Nasopharyngeal carcinoma: Molecular pathogenesis and therapeutic developments. Expert. Rev. Mol. Med. 2007, 9, 1-24.
    • (2007) Expert. Rev. Mol. Med , vol.9 , pp. 1-24
    • Tao, Q.1    Chan, A.T.2
  • 4
    • 45449090278 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma: Current management, future directions and dental implications
    • Agulnik, M.; Epstein, J.B. Nasopharyngeal carcinoma: Current management, future directions and dental implications. Oral. Oncol. 2008, 44, 617-627.
    • (2008) Oral. Oncol , vol.44 , pp. 617-627
    • Agulnik, M.1    Epstein, J.B.2
  • 5
    • 44449145617 scopus 로고    scopus 로고
    • Systemic approach to improving treatment outcome in nasopharyngeal carcinoma: Current and future directions
    • Ma, B.B.; Hui, E.P.; Chan, A.T. Systemic approach to improving treatment outcome in nasopharyngeal carcinoma: Current and future directions. Cancer Sci. 2008, 99, 1311-1318.
    • (2008) Cancer Sci , vol.99 , pp. 1311-1318
    • Ma, B.B.1    Hui, E.P.2    Chan, A.T.3
  • 7
    • 55549087936 scopus 로고    scopus 로고
    • Association of epstein-barr virus with nasopharyngeal carcinoma and current status of development of cancer-derived cell lines
    • Gullo, C.; Low, W.K.; Teoh, G. Association of epstein-barr virus with nasopharyngeal carcinoma and current status of development of cancer-derived cell lines. Ann. Acad. Med. 2008, 37, 769-777.
    • (2008) Ann. Acad. Med , vol.37 , pp. 769-777
    • Gullo, C.1    Low, W.K.2    Teoh, G.3
  • 8
    • 28844480928 scopus 로고    scopus 로고
    • Expression of VEGF as prognosticator in primary nasopharyngeal cancer and its relation to EBV status
    • Krishna, S.M.; James, S.; Balaram, P. Expression of VEGF as prognosticator in primary nasopharyngeal cancer and its relation to EBV status. Virus Res. 2006, 115, 85-90.
    • (2006) Virus Res , vol.115 , pp. 85-90
    • Krishna, S.M.1    James, S.2    Balaram, P.3
  • 9
    • 70349210826 scopus 로고    scopus 로고
    • Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma
    • Morris, M.A.; Dawson, C.W.; Young, L.S. Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma. Future Oncol. 2009, 5, 811-825.
    • (2009) Future Oncol , vol.5 , pp. 811-825
    • Morris, M.A.1    Dawson, C.W.2    Young, L.S.3
  • 10
    • 84860448909 scopus 로고    scopus 로고
    • A phase II study of concurrent cetuximab-cisplatin and intensity-modulated radiotherapy in locoregionally advanced nasopharyngeal carcinoma
    • doi:10.1093/annonc/mdr401
    • Ma, B.B.; Kam, M.K.; Leung, S.F.; Hui, E.P.; King, A.D.; Chan, S.L.; Mo, F.; Loong, H.; Yu, B.K.; Ahuja, A.; Chan, A.T. A phase II study of concurrent cetuximab-cisplatin and intensity-modulated radiotherapy in locoregionally advanced nasopharyngeal carcinoma. Ann. Oncol. 2011, doi:10.1093/annonc/mdr401.
    • (2011) Ann. Oncol
    • Ma, B.B.1    Kam, M.K.2    Leung, S.F.3    Hui, E.P.4    King, A.D.5    Chan, S.L.6    Mo, F.7    Loong, H.8    Yu, B.K.9    Ahuja, A.10    Chan, A.T.11
  • 11
    • 84861527826 scopus 로고    scopus 로고
    • A Phase II trial of erlotinib as maintenance treatment after gemcitabine plus platinum-based chemotherapy in patients with recurrent and/or metastatic nasopharyngeal carcinoma
    • doi:10.1097/COC.0b013e31820dbdcc
    • You, B. L. Tourneau, C.; Chen, E.X.; Wang, L.; Jarvi, A.; Bharadwaj, R.R.; Kamel-Reid, S.; Perez-Ordonez, B.; Mann, V.; Siu, L.L. A Phase II trial of erlotinib as maintenance treatment after gemcitabine plus platinum-based chemotherapy in patients with recurrent and/or metastatic nasopharyngeal carcinoma. Am. J. Clin. Oncol. 2011, doi:10.1097/COC.0b013e31820dbdcc.
    • (2011) Am. J. Clin. Oncol
    • You, B.L.1    Tourneau, C.2    Chen, E.X.3    Wang, L.4    Jarvi, A.5    Bharadwaj, R.R.6    Kamel-Reid, S.7    Perez-Ordonez, B.8    Mann, V.9    Siu, L.L.10
  • 12
    • 84859382989 scopus 로고    scopus 로고
    • A human Fab-based immunoconjugate specific for the LMP1 extracellular domain inhibits nasopharyngeal carcinoma growth in vitro and in vivo
    • doi:10.1158/1535-7163.MCT-11-0725
    • Renjie, C.; Dawei, Z.; Yuan, M.; Jin, Z.; Hao, M.; Juan, W.; Jun, M.; Qing, C.; Hong, L.; Qi, T.; et al. A human Fab-based immunoconjugate specific for the LMP1 extracellular domain inhibits nasopharyngeal carcinoma growth in vitro and in vivo. Mol. Cancer Ther. 2011, doi:10.1158/1535-7163.MCT-11-0725.
    • (2011) Mol. Cancer Ther
    • Renjie, C.1    Dawei, Z.2    Yuan, M.3    Jin, Z.4    Hao, M.5    Juan, W.6    Jun, M.7    Qing, C.8    Hong, L.9    Qi, T.10
  • 13
    • 20444459895 scopus 로고    scopus 로고
    • Formation of DNA interstrand cross-links as a marker of Mitomycin C bioreductive activation and chemosensitivity
    • Volpato, M.; Seargent, J.; Loadman, P.M.; Phillips, R.M. Formation of DNA interstrand cross-links as a marker of Mitomycin C bioreductive activation and chemosensitivity. Eur. J. Cancer. 2005, 41, 1331-1338.
    • (2005) Eur. J. Cancer , vol.41 , pp. 1331-1338
    • Volpato, M.1    Seargent, J.2    Loadman, P.M.3    Phillips, R.M.4
  • 14
    • 80051546328 scopus 로고    scopus 로고
    • Intracellular delivery of mitomycin C with targeted polysaccharide conjugates against multidrug resistance
    • Cao, Y.; Chen, D.; Zhao, P.; Liu, L.; Huang, X.; Qi, C.; Liu, Y.; He, H.; Wang, Q.; Liu, Y.; Chen, S. Intracellular delivery of mitomycin C with targeted polysaccharide conjugates against multidrug resistance. Ann. Biomed. Eng. 2011, 39, 2456-2465.
    • (2011) Ann. Biomed. Eng , vol.39 , pp. 2456-2465
    • Cao, Y.1    Chen, D.2    Zhao, P.3    Liu, L.4    Huang, X.5    Qi, C.6    Liu, Y.7    He, H.8    Wang, Q.9    Liu, Y.10    Chen, S.11
  • 15
    • 84863280066 scopus 로고    scopus 로고
    • Inhibiting effect of mitomycin C on human nasopharyngeal carcinoma cell line HNE2, HNE2/lmp1 and its mechanism
    • Ming, H.; Zhang, D.; Lin, H.; Chen, R.; Feng, Z.; Zhu, J. Inhibiting effect of mitomycin C on human nasopharyngeal carcinoma cell line HNE2, HNE2/lmp1 and its mechanism. J. Clin. Med. Prac. 2009, 13, 21-32.
    • (2009) J. Clin. Med. Prac , vol.13 , pp. 21-32
    • Ming, H.1    Zhang, D.2    Lin, H.3    Chen, R.4    Feng, Z.5    Zhu, J.6
  • 16
    • 73349119643 scopus 로고    scopus 로고
    • A phase II study of intra-arterial chemotherapy of 5-fluorouracil, cisplatin, and mitomycin C for advanced nonresectable gastric cancer
    • Li, M.; Zhang, J.; Wang, D.; Zhong, B.; Tucker, S.; Lu, C.; Cheng, J.; Cao, C.; Xu, J.; Xu, J.; Pan, H. A phase II study of intra-arterial chemotherapy of 5-fluorouracil, cisplatin, and mitomycin C for advanced nonresectable gastric cancer. Anticancer 2009, 20, 941-945.
    • (2009) Anticancer , vol.20 , pp. 941-945
    • Li, M.1    Zhang, J.2    Wang, D.3    Zhong, B.4    Tucker, S.5    Lu, C.6    Cheng, J.7    Cao, C.8    Xu, J.9    Xu, J.10    Pan, H.11
  • 17
    • 63949087537 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of mitomycin C and celecoxib as potential modulators of tumor resistance to irinotecan in patients with solid malignancies
    • Xu, Y.; Kolesar, J.M.; Schaaf, L.J.; Drengler, R.; Duan, W.; Otterson, G.; Shapiro, C.; Kuhn, J.; Villalona-Calero, M.A. Phase I and pharmacokinetic study of mitomycin C and celecoxib as potential modulators of tumor resistance to irinotecan in patients with solid malignancies. Cancer Chemother. Pharmacol. 2009, 63, 1073-1082.
    • (2009) Cancer Chemother. Pharmacol , vol.63 , pp. 1073-1082
    • Xu, Y.1    Kolesar, J.M.2    Schaaf, L.J.3    Drengler, R.4    Duan, W.5    Otterson, G.6    Shapiro, C.7    Kuhn, J.8    Villalona-Calero, M.A.9
  • 18
    • 43949113261 scopus 로고    scopus 로고
    • DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma
    • Lu, Z.X.; Ma, X.Q.; Yang, L.F.; Wang, Z.L.; Zeng, L.; Li, Z.J.; Li, X.N.; Tang, M.; Yi, W.; Gong, J.P.; et al. DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma. Cancer Lett. 2008, 265, 226-238.
    • (2008) Cancer Lett , vol.265 , pp. 226-238
    • Lu, Z.X.1    Ma, X.Q.2    Yang, L.F.3    Wang, Z.L.4    Zeng, L.5    Li, Z.J.6    Li, X.N.7    Tang, M.8    Yi, W.9    Gong, J.P.10
  • 19
    • 63849262293 scopus 로고    scopus 로고
    • Enhancing the in vivo expansion of adoptively transferred EBVspecific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients
    • Louis, C.U.; Straathof, K.; Bollard, C.M.; Gerken, C.; Huls, M.H.; Gresik, M.V.; Wu, M.F.; Weiss, H.L.; Gee, A.P.; Brenner, M.K.; et al. Enhancing the in vivo expansion of adoptively transferred EBVspecific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients. Blood 2009, 113, 2442-2450.
    • (2009) Blood , vol.113 , pp. 2442-2450
    • Louis, C.U.1    Straathof, K.2    Bollard, C.M.3    Gerken, C.4    Huls, M.H.5    Gresik, M.V.6    Wu, M.F.7    Weiss, H.L.8    Gee, A.P.9    Brenner, M.K.10
  • 20
    • 69449087653 scopus 로고    scopus 로고
    • Decoy receptor 3, upregulated by Epstein-Barr virus latent membrane protein 1, enhances nasopharyngeal carcinoma cell migration and invasion
    • Ho, C.H.; Chen, C.L.; Li, W.Y.; Chen, C.J. Decoy receptor 3, upregulated by Epstein-Barr virus latent membrane protein 1, enhances nasopharyngeal carcinoma cell migration and invasion. Carcinogenesis 2009, 30, 1443-1451.
    • (2009) Carcinogenesis , vol.30 , pp. 1443-1451
    • Ho, C.H.1    Chen, C.L.2    Li, W.Y.3    Chen, C.J.4
  • 21
    • 78349272806 scopus 로고    scopus 로고
    • A randomized phase III study of the docetaxel/carboplatin combination versus docetaxel single-agent as second line treatment for patients with advanced/metastatic non-small cell lung cancer
    • doi:10.1186/ 1471-2407-10-633
    • Pallis, A.G.; Agelaki, S.; Agelidou, A.; Varthalitis, I.; Syrigos, K.; Kentepozidis, N.; Pavlakou, G.; Kotsakis, A.; Kontopodis, E.; Georgoulias, V. A randomized phase III study of the docetaxel/carboplatin combination versus docetaxel single-agent as second line treatment for patients with advanced/metastatic non-small cell lung cancer. BMC Cancer 2010, 10, doi:10.1186/ 1471-2407-10-633.
    • (2010) BMC Cancer , vol.10
    • Pallis, A.G.1    Agelaki, S.2    Agelidou, A.3    Varthalitis, I.4    Syrigos, K.5    Kentepozidis, N.6    Pavlakou, G.7    Kotsakis, A.8    Kontopodis, E.9    Georgoulias, V.10
  • 22
    • 41649101808 scopus 로고    scopus 로고
    • Anti-cancer effects of xanthones from pericarps of mangosteen
    • Akao, Y.; Nakagawa, Y.; Iinuma, M.; Nozawa, Y. Anti-cancer effects of xanthones from pericarps of mangosteen. Int. J. Mol. Sci. 2008, 9, 355-370.
    • (2008) Int. J. Mol. Sci , vol.9 , pp. 355-370
    • Akao, Y.1    Nakagawa, Y.2    Iinuma, M.3    Nozawa, Y.4
  • 23
    • 79959340173 scopus 로고    scopus 로고
    • Mitomycin-C-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: Cumulative toxicity of an old drug in a new era
    • El-Ghazal, R.; Podoltsev, N.; Marks, P.; Chu, E.; Saif, M.W. Mitomycin-C-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: Cumulative toxicity of an old drug in a new era. Clin. Colorectal. Cancer 2011, 10, 142-145.
    • (2011) Clin. Colorectal. Cancer , vol.10 , pp. 142-145
    • El-Ghazal, R.1    Podoltsev, N.2    Marks, P.3    Chu, E.4    Saif, M.W.5
  • 24
    • 71049152019 scopus 로고    scopus 로고
    • Curcumin reduced the side effects of mitomycin C by inhibiting GRP58-mediated DNA cross-linking in MCF-7 breast cancer xenografts
    • Zhou, Q.M.; Zhang, H.; Lu, Y.Y.; Wang, X.F.; Su, S.B. Curcumin reduced the side effects of mitomycin C by inhibiting GRP58-mediated DNA cross-linking in MCF-7 breast cancer xenografts. Cancer Sci. 2009, 100, 2040-2045.
    • (2009) Cancer Sci , vol.100 , pp. 2040-2045
    • Zhou, Q.M.1    Zhang, H.2    Lu, Y.Y.3    Wang, X.F.4    Su, S.B.5
  • 26
    • 67949094077 scopus 로고    scopus 로고
    • COX-2, VEGF and tumour angiogenesis
    • Toomey, D.P.; Murphy, J.F.; Conlon, K.C. COX-2, VEGF and tumour angiogenesis. Surgeon 2009, 7, 174-180.
    • (2009) Surgeon , vol.7 , pp. 174-180
    • Toomey, D.P.1    Murphy, J.F.2    Conlon, K.C.3
  • 28
    • 0141537121 scopus 로고    scopus 로고
    • Expression of JAK3 in nasopharyngeal carcinoma cell line associated with STAT activation regulated by EB virus encoded protein LMP1
    • Tan, Y.N.; Tao, Y.G.; Song, X.; Tang, M.; Ai, M.D.; Cao, Y. Expression of JAK3 in nasopharyngeal carcinoma cell line associated with STAT activation regulated by EB virus encoded protein LMP1. Prog. Biochem. Biophys. 2003, 30, 560-565.
    • (2003) Prog. Biochem. Biophys , vol.30 , pp. 560-565
    • Tan, Y.N.1    Tao, Y.G.2    Song, X.3    Tang, M.4    Ai, M.D.5    Cao, Y.6
  • 29
    • 78049295535 scopus 로고    scopus 로고
    • STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling
    • Wang, Z.; Luo, F.; Li, L.; Yang, L.; Hu, D.; Ma, X.; Lu, Z.; Sun, L.; Cao, Y. STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling. Eur. J. Cancer 2009, 46, 2996-3006.
    • (2009) Eur. J. Cancer , vol.46 , pp. 2996-3006
    • Wang, Z.1    Luo, F.2    Li, L.3    Yang, L.4    Hu, D.5    Ma, X.6    Lu, Z.7    Sun, L.8    Cao, Y.9
  • 30
    • 0032899210 scopus 로고    scopus 로고
    • Malignancies of the uterine corpus and immunoreactivity score of the DNA "mismatch-repair" enzyme human Mut-S-homologon-2
    • Friedrich, M.; Villena-Heinsen, C.; Reitnauer, K.; Schmidt, W.; Tilgen, W.; Reichrath, J. Malignancies of the uterine corpus and immunoreactivity score of the DNA "mismatch-repair" enzyme human Mut-S-homologon-2. J. Histochem. Cytochem. 1999, 47, 113-118.
    • (1999) J. Histochem. Cytochem , vol.47 , pp. 113-118
    • Friedrich, M.1    Villena-Heinsen, C.2    Reitnauer, K.3    Schmidt, W.4    Tilgen, W.5    Reichrath, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.