Mitogen-activated protein kinase phosphatase-1 inhibits myocardial TNF-α expression and improves cardiac function during endotoxemia

Cardiovascular Research

Volumn 93, Issue 3, 2012, Pages 471-479

  Zhang, Ting ^a   Lu, Xiangru ^a,b   Arnold, Paul ^a   Liu, Yin ^a   Baliga, Reshma ^c,d   Huang, Hong ^c,d   Bauer, John Anthony ^c,d   Liu, Yusen ^c,d   Feng, Qingping ^a,b  

^a WESTERN UNIVERSITY   (Canada)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c NATIONWIDE CHILDREN S HOSPITAL   (United States)

^d THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Cardiac function; Lipopolysaccharide; MKP1; Sepsis; TNF

Indexed keywords

LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; P21 ACTIVATED KINASE 1; RAC1 PROTEIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART FUNCTION; HEART MUSCLE; HEART MUSCLE CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; DUAL SPECIFICITY PHOSPHATASE 1; ENDOTOXEMIA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 8; MYOCARDIUM; NEUROPEPTIDES; P21-ACTIVATED KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RAC GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863254909     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr346     Document Type: Article

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