Simultaneous quantification of 19 drugs/metabolites in urine important for pain management by liquid chromatography-tandem mass spectrometry

Clinical Chemistry and Laboratory Medicine

Volumn 50, Issue 1, 2012, Pages 95-103

  Yuan, Chao ^a   Heideloff, Courtney ^a   Kozak, Marta ^b   Wang, Sihe ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Thermo Fisher Scientific   (United States)

Author keywords

Drugs of abuse; Liquid chromatography tandem mass spectrometry; Pain management; Quantification; Turbulent flow

Indexed keywords

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; AMPHETAMINE; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BENZOYLECGONINE; CANNABIS; COCAINE; CODEINE; DEXTROPROPOXYPHENE; DIHYDROCODEINE; FENTANYL; HYDROCODONE; HYDROMORPHONE; LYSERGIDE; METHADONE; METHAMPHETAMINE; MORPHINE; NORFENTANYL; NORPROPOXYPHENE; O NORTRAMADOL; OXYCODONE; OXYMORPHONE; PHENCYCLIDINE; TETRAHYDROCANNABINOLIC ACID; TRAMADOL; UNCLASSIFIED DRUG;

ACCURACY; ANALGESIA; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DILUTION; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG URINE LEVEL; HUMAN; HYDROLYSIS; MAJOR CLINICAL STUDY; METABOLITE; PATIENT COMPLIANCE; PATIENT MONITORING; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TURBULENT FLOW;

CHROMATOGRAPHY, LIQUID; HUMANS; PAIN; PAIN MANAGEMENT; PHARMACEUTICAL PREPARATIONS; STREET DRUGS; TANDEM MASS SPECTROMETRY; UNITED STATES; URINALYSIS;

EID: 84863248840     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.739     Document Type: Article

References (33)

1. Compton P, Athanasos P. Chronic pain, substance abuse and addiction. Nurs Clin North Am 2003;38:525-37. (Pubitemid 38609549)
2. Manchikanti L, Cash KA, Damron KS, Manchukonda R, Pampati V, McManus CD. Controlled substance abuse and illicit drug use in chronic pain patients: an evaluation of multiple variables. Pain Physician 2006;9:215-25.
3. Chabal C, Erjavec MK, Jacobson L, Mariano A, Chaney E. Prescription opiate abuse in chronic pain patients: clinical criteria, incidence, and predictors. Clin J Pain 1997;13:150-5. (Pubitemid 27251109)
4. Manchikanti L, Pampati V, Damron KS, Fellows B, Barnhill RC, Beyer CD. Prevalence of opioid abuse in interventional pain medicine practice settings: a randomized clinical evaluation. Pain Physician 2001;4:358-65. (Pubitemid 33062074)
5. Katz NP, Sherburne S, Beach M, Rose RJ, Vielguth J, Bradley J, et al. Behavioral monitoring and urine toxicology testing in patients receiving long-term opioid therapy. Anesth Analg 2003;97:1097-102, table of contents. (Pubitemid 37158696)
6. Volkow ND, McLellan TA. Curtailing diversion and abuse of opioid analgesics without jeopardizing pain treatment. J Am Med Assoc 2011;305:1346-7.
7. Reisfield GM, Salazar E, Bertholf RL. Rational use and interpretation of urine drug testing in chronic opioid therapy. Ann Clin Lab Sci 2007;37:301-14. (Pubitemid 350105930)
8. Manchikanti L, Manchukonda R, Pampati V, Damron KS, Brandon DE, Cash KA, et al. Does random urine drug testing reduce illicit drug use in chronic pain patients receiving opioids? Pain Physician 2006;9:123-9.
9. Katz N, Fanciullo GJ. Role of urine toxicology testing in the management of chronic opioid therapy. Clin J Pain 2002;18: S76-82. (Pubitemid 34815397)
10. Christo PJ, Manchikanti L, Ruan X, Bottros M, Hansen H, Solanki DR, et al. Urine drug testing in chronic pain. Pain Physician 2011;14:123-43.
11. Moriya F, Chan KM, Hashimoto Y. Concentrations of morphine and codeine in urine of heroin abusers. Leg Med (Tokyo) 1999;1:140-4.
12. Fraser AD, Worth D. Urinary excretion profiles of 11-nor-9-car-boxy- delta9-tetrahydrocannabinol: a delta9-thccooh to creatinine ratio study. J Anal Toxicol 1999;23:531-4. (Pubitemid 29473409)
13. Porter WH. Clinical toxicology. In: Burtis CA, Ashwood EA, Bruns DE, eds. Tietz textbook of clinical chemistry adn molecular diagnostics, 4th ed. St. Louis, MO: Elsevier Saunders, 2006;1287-370.
14. Chen ZR, Somogyi AA, Reynolds G, Bochner F. Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers. Br J Clin Pharmacol 1991;31:381-90.
15. Hackett LP, Dusci LJ, Ilett KF, Chiswell GM. Optimizing the hydrolysis of codeine and morphine glucuronides in urine. Ther Drug Monit 2002;24:652-7.
16. Jennison TA, Wozniak E, Nelson G, Urry FM. The quantitative conversion of morphine 3-beta-d glucuronide to morphine using beta-glucuronidase obtained from patella vulgata as compared to acid hydrolysis. J Anal Toxicol 1993;17:208-10. (Pubitemid 23212199)
17. Eichhorst JC, Etter ML, Rousseaux N, Lehotay DC. Drugs of abuse testing by tandem mass spectrometry: a rapid, simple method to replace immunoassays. Clin Biochem 2009;42:1531-42.
18. de Castro A, Concheiro M, Shakleya DM, Huestis MA. Development and validation of a liquid chromatography mass spectrometry assay for the simultaneous quantification of methadone, cocaine, opiates and metabolites in human umbilical cord. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877:3065-71.
19. Rook EJ, Hillebrand MJ, Rosing H, van Ree JM, Beijnen JH. The quantitative analysis of heroin, methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chroma-tography coupled with tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2005;824:213-21. (Pubitemid 41215600)
20. Badawi N, Simonsen KW, Steentoft A, Bernhoft IM, Linnet K. Simultaneous screening and quantification of 29 drugs of abuse in oral fluid by solid-phase extraction and ultraperformance lc-ms/ms. Clin Chem 2009;55:2004-18.
21. Huwyler J, Rufer S, Kusters E, Drewe J. Rapid and highly automated determination of morphine and morphine glucuronides in plasma by on-line solid-phase extraction and column liquid chro-matography. J Chromatogr B Biomed Appl 1995;674:57-63.
22. Mueller DM, Duretz B, Espourteille FA, Rentsch KM. Development of a fully automated toxicological lc-ms(n) screening system in urine using online extraction with turbulent flow chro-matography. Anal Bioanal Chem 2010;400:89-100.
23. Feng J, Wang L, Dai I, Harmon T, Bernert JT. Simultaneous determination of multiple drugs of abuse and relevant metabolites in urine by lc-ms-ms. J Anal Toxicol 2007;31:359-68. (Pubitemid 47451063)
24. Teixeira H, Verstraete A, Proenca P, Corte-Real F, Monsanto P, Vieira DN. Validated method for the simultaneous determination of delta9-thc and delta9-thc-cooh in oral fluid, urine and whole blood using solid-phase extraction and liquid chromatography-mass spectrometry with electrospray ionization. Forensic Sci Int 2007;170:148-55. (Pubitemid 47088879)
25. Stannard CF. Opioids for chronic pain: promise and pitfalls. Curr Opin Support Palliat Care 2011;5:150-7.
26. Banken JA. Drug abuse trends among youth in the United States. Ann NY Acad Sci 2004;1025:465-71. (Pubitemid 39643895)
27. Bermes EW, Kahn SE, Young DS. Introduction to principles of laboratory analyses and safty. In: Burtis CA, Ashwood EA, Bruns DE, editors. Tietz textbook of clinical chemistry and molecular diagnostics, 4th ed. St. Louis, MO: Elsevier Saunders, 2006; 3-40.
28. Bunch DR, Miller AY, Wang S. Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin d2/d3 using a turbulent flow online extraction technology. Clin Chem Lab Med 2009;47:1565-72.
29. Bonfiglio R, King RC, Olah TV, Merkle K. The effects of sample preparation methods on the variability of the electrospray ioniza-tion response for model drug compounds. Rapid Commun Mass Spectrom 1999;13:1175-85. (Pubitemid 29285118)
30. Crews B, Mikel C, Latyshev S, West R, Pesce A. Unstable propoxyphene metabolite excreted in human urine is detected by liquid chromatography-tandem mass spectrometry. J Anal Toxicol 2009;33:379-83.
31. Jian H, Ybarra S, Johnson D, Dilek I, Sreenivasan U. An investigation of norpropoxyphene cyclization in methanol. The Society of Forensic Toxicologists Conference. Oklahoma City, 2009.
32. Corcione S, Pichini S, Badia R, Segura J, de la Torre R. Quantitative aspects of drugs of abuse in urine samples: intercol-laborative studies conducted in the European Union. Ther Drug Monit 1999;21:653-60.
33. Combie J, Blake JW, Nugent TE, Tobin T. Morphine glucuronide hydrolysis: superiority of beta-glucuronidase from patella vul-gata. Clin Chem 1982;28:83-6. (Pubitemid 12209757)