Excessive CD4 + T cells co-expressing interleukin-17 and interferon-γ in patients with Behçet's disease

Clinical and Experimental Immunology

Volumn 168, Issue 1, 2012, Pages 68-74

  Shimizu, J ^a   Takai, K ^a   Fujiwara, N ^a   Arimitsu, N ^a   Ueda, Y ^a   Wakisaka, S ^a   Yoshikawa, H ^a   Kaneko, F ^b   Suzuki, T ^a   Suzuki, N ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Beh et's disease; Cytokines interleukins; Th17 cells

Indexed keywords

CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 23 RECEPTOR; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA;

ADULT; ARTICLE; BEHCET DISEASE; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE SUBPOPULATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN DEFECT; TH0 CELL; TH1 CELL; TH17 CELL; TH2 CELL; UPREGULATION;

ADULT; ANTIGENS, CD45; BEHCET SYNDROME; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-23; MALE; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; RNA, MESSENGER; SKIN; TH1 CELLS; TH17 CELLS;

EID: 84863247416     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04543.x     Document Type: Article

References (41)

1. Sakane T, Takeno M, Suzuki N etal. Behçet's disease. N Engl J Med 1999; 341:1284-91.
2. Nagafuchi H, Takeno M, Yoshikawa H etal. Excessive expression of Txk, a member of the Tec family of tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behçet's disease. Clin Exp Immunol 2005; 139:363-70.
3. Imamura Y, Kurokawa MS, Yoshikawa H etal. Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behçet's disease. Clin Exp Immunol 2005; 139:371-8.
4. Melikoglu M, Uysal S, Krueger JG etal. Characterization of the divergent wound-healing responses occurring in the pathergy reaction and normal healthy volunteers. J Immunol 2006; 177:6415-21.
5. Ben Ahmed M, Houman H, Miled M etal. Involvement of chemokines and Th1 cytokines in the pathogenesis of mucocutaneous lesions of disease. Arthritis Rheum 2004; 50:2291-5.
6. Kulaber A, Tugal-Tutkun I, Yentür SP etal. Pro-inflammatory cellular immune response in Behçet's disease. Rheumatol Int 2007; 27:1113-8.
7. Melikoglu M, Kural-Seyahi E, Tascilar K etal. The unique features of vasculitis in Behçet's syndrome. Clin Rev Allergy Immunol 2008; 35:40-6.
8. Milner JD, Brenchley JM, Laurence A etal. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 2008; 452:773-6.
9. Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 2008; 9:641-9.
10. Wilson NJ, Boniface K, Chan JR etal. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007; 8:950-7.
11. Voo KS, Wang YH, Santori FR etal. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci USA 2009; 106:4793-8.
12. Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum 2007; 56:2936-46.
13. Kobayashi T, Okamoto S, Hisamatsu T etal. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 2008; 57:1682-9.
14. Fujino S, Andoh A, Bamba S etal. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003; 52:65-70.
15. Brucklacher-Waldert V, Stuerner K, Kolster M etal. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009; 132:3329-41.
16. Chi W, Zhu X, Yang P etal. Upregulated IL-23 and IL-17 in Behçet patients with active uveitis. Invest Ophthalmol Vis Sci 2008; 49:3058-64.
17. Hamzaoui K, Bouali E, Ghorbel I etal. Expression of Th-17 and RORγt mRNA in Behçet's disease. Med Sci Monit 2011; 17:CR227-34.
18. Geri G, Terrier B, Rosenzwajg M etal. Critical role of IL-21 in modulating T(H)17 and regulatory T cells in Behçet disease. J Allergy Clin Immunol 2011; 128:655-64.
19. Hamzaoui K, Borhani Haghighi A, Ghorbel IB etal. RORC and Foxp3 axis in cerebrospinal fluid of patients with neuro-Behçet's disease. J Neuroimmunol 2011; 233:249-53.
20. Chi W, Yang P, Zhu X etal. Production of interleukin-17 in Behçet's disease is inhibited by cyclosporin A. Mol Vis 2010; 16:880-6.
21. Bending D, De la Peña H, Veldhoen M etal. Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest 2009; 119:565-72.
22. Martin-Orozco N, Chung Y, Chang SH etal. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol 2009; 39:216-24.
23. Shi G, Cox CA, Vistica BP etal. Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J Immunol 2008; 181:7205-13.
24. Lee YK, Turner H, Maynard CL etal. Late developmental plasticity in the T helper 17 lineage. Immunity 2009; 30:92-107.
25. Sujino T, Kanai T, Ono Y etal. Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells. Gastroenterology 2011; 141:1014-23.
26. Lee YK, Menezes JS, Umesaki Y etal. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2011; 108:4615-22.
27. International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 1990; 335:1078-80.
28. Pepper M, Jenkins MK. Origins of CD4(+) effector and central memory T cells. Nat Immunol 2011; 12:467-71.
29. Cassidy LD. Basic concepts of statistical analysis for surgical research. J Surg Res 2005; 128:199-206.
30. Reboldi A, Coisne C, Baumjohann D etal. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 2009; 10:514-23.
31. Annunziato F, Cosmi L, Santarlasci V etal. Phenotypic and functional features of human Th17 cells. J Exp Med 2007; 204:1849-61.
32. Hänsel A, Günther C, Ingwersen J etal. Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong TH17/TH1 T-cell responses. J Allergy Clin Immunol 2011; 127:787-94.
33. Kebir H, Ifergan I, Alvarez JI etal. Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis. Ann Neurol 2009; 66:390-402.
34. Edwards LJ, Robins RA, Constantinescu CS. Th17/Th1 phenotype in demyelinating disease. Cytokine 2010; 50:19-23.
35. Nistala K, Adams S, Cambrook H etal. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc Natl Acad Sci USA 2010; 107:14751-6.
36. Cosmi L, Cimaz R, Maggi L etal. Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis. Arthritis Rheum 2011; 63:2504-15.
37. Das J, Ren G, Zhang L etal. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009; 206:2407-16.
38. Ghoreschi K, Laurence A, Yang XP etal. Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature 2010; 467:967-71.
39. Mizuki N, Meguro A, Ota M etal. Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. Nat Genet 2010; 42:703-6.
40. Remmers EF, Cosan F, Kirino Y etal. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet 2010; 42:698-702.
41. Jiang Z, Yang P, Hou S etal. IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population. Ann Rheum Dis 2010; 69:1325-8.