Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: Pyrrole regioisomers and propionic acid replacement

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 12, 2011, Pages 3671-3675

  Sun, Xicheng ^a   Qiu, Jian ^a   Strong, Sarah A ^a   Green, Louis S ^a   Wasley, Jan W F ^b   Colagiovanni, Dorothy B ^a   Mutka, Sarah C ^a   Blonder, Joan P ^a   Stout, Adam M ^a   Richards, Jane P ^a   Chun, Lawrence ^c   Rosenthal, Gary J ^a  

^a N30 Pharmaceuticals LLC   (United States)

^b Simpharma LLC   (United States)

^c Emerald BioStructures   (United States)

Author keywords

GSNO; GSNOR; GSNOR inhibitor; N6022; Nitric oxide; Pyrrole

Indexed keywords

MOLECULAR SCAFFOLD; N 6022; OXIDOREDUCTASE; OXIDOREDUCTASE INHIBITOR; PROPIONIC ACID; PYRROLE DERIVATIVE; S NITROSOGLUTATHIONE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ALDEHYDE OXIDOREDUCTASES; ENZYME ACTIVATION; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROPIONIC ACIDS; PYRROLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79957832082     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.086     Document Type: Article

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