Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5849-5853

  Sun, Xicheng ^a   Qiu, Jian ^a   Strong, Sarah A ^a   Green, Louis S ^a   Wasley, Jan W F ^b   Blonder, Joan P ^a   Colagiovanni, Dorothy B ^a   Mutka, Sarah C ^a   Stout, Adam M ^a   Richards, Jane P ^a   Rosenthal, Gary J ^a  

^a N30 Pharmaceuticals LLC   (United States)

^b Simpharma LLC   (United States)

Author keywords

Cytochrome P450; GSNO; GSNOR; GSNOR inhibitor; N6022; Nitric oxide

Indexed keywords

N 6022; OVALBUMIN; OXIDOREDUCTASE INHIBITOR; PYRROLE DERIVATIVE; S NITROSOGLUTATHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; ASTHMA; BENZAMIDES; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; LUNG; MICE; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PYRROLES; RECEPTORS, OPIOID, DELTA; S-NITROSOGLUTATHIONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052564633     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.103     Document Type: Article

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