Discovery of S-nitrosoglutathione reductase inhibitors: Potential agents for the treatment of asthma and other inflammatory diseases

ACS Medicinal Chemistry Letters

Volumn 2, Issue 5, 2011, Pages 402-406

  Sun, Xicheng ^a   Wasley, Jan W F ^b   Qiu, Jian ^a   Blonder, Joan P ^a   Stout, Adam M ^a   Green, Louis S ^a   Strong, Sarah A ^a   Colagiovanni, Dorothy B ^a   Richards, Jane P ^a   Mutka, Sarah C ^a   Chun, Lawrence ^c   Rosenthal, Gary J ^a  

^a N30 Pharmaceuticals LLC   (United States)

^b Simpharma LLC   (United States)

^c Emerald BioStructures   (United States)

Author keywords

asthma; GSNO; GSNOR; N6022; nitric oxide; pyrrole

Indexed keywords

ALCOHOL DEHYDROGENASE; ALLERGEN; ANTIINFLAMMATORY AGENT; BRONCHOCONSTRICTING AGENT; CARBOXYLIC ACID; CYSTEINE; HISTIDINE; IMIDAZOLE; N 6022; NICOTINAMIDE ADENINE DINUCLEOTIDE; S NITROSOGLUTATHIONE; S NITROSOGLUTATHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHOSPASM; CYTOTOXICITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VIVO STUDY; INFLAMMATORY DISEASE; MOUSE; NONHUMAN; PLASMA CLEARANCE; PNEUMONIA; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALIA; MUS;

EID: 79956145676     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200045s     Document Type: Article

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