Correlation between homeodomain-interacting protein kinase 2 and apoptosis in cervical cancer

Molecular Medicine Reports

Volumn 5, Issue 5, 2012, Pages 1251-1255

  Cheng, Yu ^a   Al Beiti, Mariam A M ^a   Wang, Junchen ^b   Wei, Guangwei ^c   Li, Jun ^a   Liang, Shanhui ^a   Lu, Xin ^a  

^a FUDAN UNIVERSITY   (China)

^b Tongji University   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cervical cancer; Homeodomain interacting protein kinase 2; RNA interference

Indexed keywords

COMPLEMENTARY DNA; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; MESSENGER RNA; RNA; TUMOR MARKER;

APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; CLINICAL ARTICLE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UTERINE CERVIX CANCER; WESTERN BLOTTING;

ADULT; AGED; APOPTOSIS; CARRIER PROTEINS; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MIDDLE AGED; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; RNA, NEOPLASM; UTERINE CERVICAL NEOPLASMS;

EID: 84863233085     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.810     Document Type: Article

References (17)

1. Schiller JT and Lowy DR: Prospects for cervical cancer prevention by human papillomavirus vaccination. Cancer Res 66: 10229-10232, 2006. (Pubitemid 44799735)
2. Muñoz N, Bosch FX, de Sanjosé S, et al: Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348: 518-527, 2003. (Pubitemid 36159887)
3. Parkin DM and Bray F. Chapter 2: the burden of HPV-related cancers. Vaccine 24: S11-S25, 2006. (Pubitemid 44404053)
4. Vinokurova S, Wentzensen N, Kraus I, et al: Type-dependent integration frequency of human papillomavirus genomes in cervical lesions. Cancer Res 68: 307-313, 2008. (Pubitemid 351380133)
5. Lazo PA: The molecular genetics of cervical carcinoma. Br J Cancer 80: 2008-2018, 1999.
6. Kim YH, Choi CY, Lee SJ, Conti MA and Kim Y: Homeodomain-interacting protein kinase, a novel family of corepressors for homeodomain transcription factors. J Biol Chem 273: 875-879, 1998.
7. Pierantoni GM, Bulfone A, Pentimalli F, et al: The homeo- domain-interacting protein kinase2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues. Biochem Biophys Res Commun 290: 942-947, 2002. (Pubitemid 34687452)
8. Wang Y, Hofmann TG, Runkel L, et al: Isolation and characterization of cDNAs for the protein kinase HIPK2. Biochim Biophys Acta 1518: 168-172, 2001.
9. D'Orazi G, Sciulli MG, Di Stefano V, et al: Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells. Clin Cancer Res 12: 735-741, 2006. (Pubitemid 43259852)
10. Al-Beiti M and Lu X: Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis. Aust N Z J Obstet Gynaecol 48: 329-336, 2008. (Pubitemid 351798374)
11. Pierantoni GM, Fedele M, Pentinalli F, et al: High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth. Oncogene 20: 6132-6141, 2001. (Pubitemid 32964425)
12. Dauth I, Krüger J and Hofmann TG: Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. Cancer Res 67: 2274-2279, 2007. (Pubitemid 46424247)
13. Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
14. Hofmann TG, Moller A, Sirma H, et al: Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase 2. Nat Cell Biol 4: 1-10, 2002. (Pubitemid 34071974)
15. D'Orazi G, Cecchinelli B, Bruno T, et al: Homeodomain-interacting protein kinase 2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4: 11-19, 2002.
16. Wang Y, Debatin KM and Hug H: HIPK2 overexpression leads to stabilization of p53 transcriptional activity by decreasing Mdm2 protein levels. BMC Mol Biol 2: 8, 2001.
17. Gresko E, Roscic A, Ritterhoff S, Vichalkovski A, Sal G and Schmitz ML: Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. EMBO J 25: 1883-1894, 2006.