Downregulation of CNPase in a MeCP2 deficient mouse model of rett syndrome

Neurological Research

Volumn 34, Issue 2, 2012, Pages 107-113

  Wu, Wei ^a   Gu, Weizhong ^a   Xu, Xuefeng ^a   Shang, Shiqiang ^a   Zhao, Zhengyan ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

CNpase; Connexins; GFAP; Mouse model; Rett syndrome

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; CONNEXIN 32; CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CEREBELLUM; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RETT SYNDROME; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WHITE MATTER;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; ANIMALS; BLOTTING, WESTERN; BRAIN; CONNEXINS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, MUTANT STRAINS; MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; RETT SYNDROME; RNA, MESSENGER;

EID: 84863233032     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/016164111X13214359296301     Document Type: Article

References (27)

1. Amir RE, van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 1999;23:185-8.
2. Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, et al. MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 2008;320:1224-9.
3. Shahbazian M, Young J, Yuva-Paylor L, Spencer C, Antalffy B, Noebels J, et al. Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 2002;35:243-54.
4. Johnston MV, Blue ME, Naidu S. Rett syndrome and neuronal development. J Child Neurol 2005;20:759-63.
5. Johnston MV, Jeon OH, Pevsner J, Blue ME, Naidu S. Neurobiology of Rett syndrome: a genetic disorder of synapse development. Brain Dev 2001;23 Suppl 1:S206-13.
6. Carlen PL, Skinner F, Zhang L, Naus C, Kushnir M, Perez Velazquez JL. The role of gap junctions in seizures. Brain Res Brain Res Rev 2000;32:235-41.
7. Fields RD, Stevens-Graham B. New insights into neuron-glia communication. Science 2002;298:556-62.
8. Maezawa I, Swanberg S, Harvey D, LaSalle JM, Jin LW. Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J Neurosci 2009;29:5051-61.
9. Gomes FC, Paulin D, Moura Neto V. Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation. Braz J Med Biol Res 1999;32:619-31.
10. Nagy JI, Ochalski PA, Li J, Hertzberg EL. Evidence for the colocalization of another connexin with connexin-43 at astrocytic gap junctions in rat brain. Neuroscience 1997;78:533-48.
11. Nagy JI, Patel D, Ochalski PA, Stelmack GL. Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance. Neuroscience 1999;88:447-68.
12. Dermietzel R, Traub O, Hwang TK, Beyer E, Bennett MV, Spray DC, et al. Differential expression of three gap junction proteins in developing and mature brain tissues. Proc Natl Acad Sci USA 1989;86:10148-52.
13. Schanen NC, Dahle EJ, Capozzoli F, Holm VA, Zoghbi HY, Francke U. A new Rett syndrome family consistent with Xlinked inheritance expands the X chromosome exclusion map. Am J Hum Genet 1997;61:634-41.
14. Gravel M, Peterson J, Yong VW, Kottis V, Trapp B, Braun PE. Overexpression of 29,39-cyclic nucleotide 39-phosphodiesterase in transgenic mice alters oligodendrocyte development and produces aberrant myelination. Mol Cell Neurosci 1996;7:453-66.
15. Jellinger K, Seitelberger F. Neuropathology of Rett syndrome. Am J Med Genet Suppl 1986;1:259-88.
16. Oldfors A, Sourander P, Armstrong DL, Percy AK, Witt-Engerström I, Hagberg BA. Rett syndrome: cerebellar pathology. Pediatr Neurol 1990;6:310-4.
17. Lekman AY, Hagberg BA, Svennerholm LT. Membrane cerebral lipids in Rett syndrome. Pediatr Neurol 1991;7:186-90.
18. Bahi-Buisson N, Nectoux J, Girard B, van Esch H, de Ravel T, Boddaert N, et al. Revisiting the phenotype associated with FOXG1 mutations: two novel cases of congenital Rett variant. Neurogenetics 2010;11:241-9.
19. Mina R. White matters in Rett syndrome: differential expression of myelin genes in the MeCP2 null mouse [thesis]. Winnipeg (MB): University of Winnipeg; 2008. p. 53.
20. Lappe-Siefke C, Goebbels S, Gravel M, Nicksch E, Lee J, Braun PE, et al. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet 2003;33:366-74.
21. Shalin SC, Egli R, Birnbaum SG, Roth TL, Levenson JM, Sweatt JD. Signal transduction mechanisms in memory disorders. Prog Brain Res 2006;157:25-41.
22. Barres BA. The mystery and magic of glia: a perspective on their roles in health and disease. Neuron 2008;60:430-40.
23. Bauman ML, Kemper TL, Arin DM. Microscopic observations of the brain in Rett syndrome. Neuropediatrics 1995;26:105-8.
24. Horska A, Farage L, Bibat G, Nagae LM, Kaufmann WE, Barker PB, et al. Brain metabolism in Rett syndrome: age, clinical, and genotype correlations. Ann Neurol 2009;65:90-7.
25. Lipani JD, Bhattacharjee MB, Corey DM, Lee DA. Reduced nerve growth factor in Rett syndrome postmortem brain tissue. J Neuropathol Exp Neurol 2000;59:889-95.
26. Colantuoni C, Jeon OH, Hyder K, Chenchik A, Khimani AH, Narayanan V, et al. Gene expression profiling in postmortem Rett Syndrome brain: differential gene expression and patient classification. Neurobiol Dis 2001;8:847-65.
27. Maezawa I, Jin LW. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. J Neurosci 2010;30:5346-56.