Connexin30 in rodent, cat and human brain: Selective expression in gray matter astrocytes, co-localization with connexin43 at gap junction and late developmental appearance

Neuroscience

Volumn 88, Issue 2, 1999, Pages 447-468

  Nagy, J I ^a   Patel, D ^a   Ochalski, P A Y ^a   Stelmack, G L ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Cell cell communication; Gap junction proteins; Glial cells; Immunogold electron microscopy; Immunohistochemistry; Oligodendrocytes

Indexed keywords

GAP JUNCTION PROTEIN;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; CAT; CELL COMMUNICATION; GAP JUNCTION; GRAY MATTER; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; ASTROCYTES; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; CATS; CELL COMMUNICATION; CONNEXIN 43; CONNEXINS; FLUORESCENT ANTIBODY TECHNIQUE; GAP JUNCTIONS; HUMANS; MALE; MICE; MICE, INBRED STRAINS; MICROSCOPY, IMMUNOELECTRON; MOLECULAR SEQUENCE DATA; OLIGODENDROGLIA; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; SPINAL CORD;

EID: 0032889958     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00191-2     Document Type: Article

References (50)

1. Bar T., Wolff J. R. The formation of capillary basement membranes during internal vascularization of the rat's cerebral cortex. Z. Zellforsch. mikrosk. Anat. 133:1972;231-248.
2. Bennett M. V. L., Barrio L. C., Bargiello T. A., Spray D. C., Hertzberg E. L., Saez J. C. Gap junctions: new tools, new answers, new questions. Neuron. 6:1991;305-320.
3. Beyer E. C., Paul D. L., Goodenough D. A. Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J. Cell Biol. 105:1987;2621-2629.
4. Beyer E. C. Gap junctions. Int. Rev. Cytol. 137:1993;1-37.
5. Bruzzone R., White T. W., Paul D. L. Expression of chimeric connexins reveals new properties of the formation and gating behavior of gap junction channels. J. Cell Sci. 107:1994;955-967.
6. Bruzzone R., White T. W., Paul D. L. Connections with connexins: the molecular basis of direct intercellular signaling. Eur. J. Biochem. 238:1996;1-27.
7. Bruzzone R., Ressot C. Connexins, gap junctions and cell-cell signalling in the nervous system. Eur. J. Neurosci. 9:1997;1-6.
8. Carpenter M. B. (1983) Interconnections between the corpus striatum and brain stem nuclei. In Advances in Behavioral Biology, The Basal Ganglia, (eds Mckenzie J. S., Kenn R. E. and Wilcock L. N.), Vol. 27, pp 1-68. Plenum, New York.
9. Dahl E., Manthey D., Chen Y., Schwarz H.-J., Chang S., Lalley P. A., Nicholson B. J., Willecke K. Molecular cloning and functional expression of mouse connexin30, a gap junction gene highly expressed in adult brain and skin. J. biol. Chem. 271:1996;17903-17910.
10. Dermietzel R., Traub O., Hwang T. K., Beyer E., Bennett M. V. L., Spray D. C., Willecke K. Differential expression of the gap junction proteins in developing and mature brain tissues. Proc. natn. Acad. Sci. U.S.A. 86:1989;10148-10152.
11. Dermietzel R., Spray D. C. Gap junctions in the brain: where, what type, how many and why? Trends Neurosci. 16:1993;186-192.
12. Dermietzel R., Faroog M., Kessler J. A., Althaus H., Hertzberg E. L., Spray D. C. Oligodendrocytes express gap junction proteins connexin32 and connexin45. Glia. 20:1997;101-114.
13. Elfgang C., Eckert R., Lichtenberg-Frate H., Butterweck A., Traub O., Klein R. A., Hulser D. F., Willecke K. Specific permeability and selective formation of gap junction channels in connexin-transfected Hela cells. J. Cell Biol. 129:1995;805-817.
14. Giaume C., Framaget C., Aoumari A. E., Cordier J., Glowinski J., Gros D. Gap junctions in cultured astrocytes: single-channel currents and characterization of channel-forming protein. Neuron. 6:1991;133-143.
15. Goodenough D. A., Goliger J. A., Paul D. L. Connexins, connexons, and intercellular communication. A. Rev. Biochem. 65:1996;475-502.
16. Hossain M. Z., Murphy L. J., Hertzberg E. L., Nagy J. I. Phosphorylated forms of connexin43 predominate in rat brain: demonstration by rapid inactivation of brain metabolism. J. Neurochem. 62:1994;2394-2403.
17. Jiang J. X., Goodenough D. A. Heteromeric connexons in lens gap junction channels. Proc. natn. Acad. Sci. U.S.A. 93:1996;1287-1291.
18. Kunzelmann P., Blumcke I., Traub O., Dermietzel R., Willecke K. Coexpression of connexin45 and -32 in oligodendrocytes of rat brain. J. Neurocytol. 26:1997;17-22.
19. Landis D. M. D., Reese T. S. Membrane structure in mammalian astrocytes: a review of freeze-fracture studies on adult, developing, reactive, and cultured astrocytes. J. exp. Biol. 96:1981;35-48.
20. Leong S. F., Clark J. B. Regional enzyme development in rat brain. Enzymes of energy metabolism. Biochem. J. 218:1984;139-145.
21. Li J., Hertzberg E. L., Nagy J. I. Connexin32 in oligodendrocytes and association with myelinated fibers in mouse and rat brain. J. comp. Neurol. 379:1997;571-591.
22. Li W. E. I., Ochalski P. A. Y., Hertzberg E. L. and Nagy J. I. (1998) Immunorecognition, ultrastructure and phosphorylation status of astrocytic gap junctions and connexin43 in rat brain after cerebral focal ischemia. (in press).
23. Massa P. T., Mugnaini E. Cell junctions and intramembrane particles of astrocytes and oligodendrocytes: a freeze-fracture study. Neuroscience. 7:1982;523-538.
24. Micevych P. E., Abelson L. Distribution of mRNAs coding for liver and heart gap junction proteins in the rat central nervous system. J. comp. Neurol. 305:1991;96-118.
25. Mugnaini E. (1986) Cell junctions of astrocytes, ependyma, and related cells in mammalian central nervous system, with emphasis on the hypothesis of a generalized functional syncytium of supporting cells. In Astrocytes (eds Fedoroff S. and Verndakis A.), Vol. 1, pp 329-371. Academic, New York.
26. Nagy J. I., Yamamoto T., Sawchuk M. A., Nance D. M., Hertzberg E. L. Quantitative immunohistochemical and biochemical correlates of connexin43 localization in rat brain. Glia. 5:1992;1-9.
27. Nagy J. I., Ochalski P. A. Y., Li J., Hertzberg E. L. Evidence for the co-localization of another connexin with connexin43 at astrocytic gap junctions in rat brain. Neuroscience. 78:1997;533-548.
28. Nagy J. I., Li W. E. I., Roy C., Dobble B. W., Gilchrist J. S., Kardami E. and Hertzberg E. L. (1997) Selective monoclonal antibody recognition and cellular localization of an unphosphorylated form of connexin43. Expl Cell Res. (in press).
29. Nagy J. I. and Dermietzel R. (1998) Gap junctions and connexins in the mammalian central nervous system. In Advances in Molecular and Cell Biology, Vol. 18 (ed. Hertzberg E. L.) JAI, New York. (in press).
30. Ochalski P. A. Y., Sawchuk M. A., Hertzberg E. L., Nagy J. I. Astrocytic gap junction removal, connexin43 redistribution and epitope masking at excitatory amino acid lesion sites in rat brain. Glia. 14:1995;279-294.
31. Ochalski P. A. Y., Frankenstein U. N., Hertzberg E. L., Nagy J. I. Connexin43 in rat spinal cord: localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctions. Neuroscience. 76:1997;931-945.
32. Phelps C. H. The development of gliovascular relationships in the rat spinal cord. An electron microscopic study. Z. Zellforsch. mikrosk. Anat. 128:1972;555-563.
33. Scherer S. S., Deschenes S. M., Xu Y.-T., Grinspan J. B., Fishbeck K. H., Paul D. L. Connexin32 is a myelin-related protein in the PNS and CNS. J. Neurosci. 15:1995;8281-8294.
34. Spray D. C., Moreno A. P., Kessler J. A., Dermietzel R. Characterization of gap junctions between cultured leptomeningeal cells. Brain Res. 568:1991;1-14.
35. Spray D. C., Viera D., El-sabban M. E., Gao Y., Bennett M. V. L. Gap junction properties in astrocytes from connexin43 (connexin43) knockout (KO) mice. Soc. Neurosci. Abstr. 21:1995;563.
36. Stauffer K. A. The gap junction protein b1-connexin (connexin-32) and b2-connexin (connexin26) can form heteromeric hemichannels. J. biol. Chem. 270:1995;6768-6772.
37. Steindler D. A. Glial boundaries in the developing nervous system. A. Rev. Neurosci. 16:1993;445-470.
38. Swenson K. I., Jordan J. R., Beyer E. C., Paul D. L. Formation of gap junctions by expression of connexins in Xenopus oocyte pairs. Cell. 57:1989;145-155.
39. Traub O., Look J., Dermietzel R., Brummer F., Hulser D., Willicke K. Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes. J. Cell Biol. 108:1989;1039-1051.
40. Tsacopoulos M., Magistretti P. J. Metabolic coupling between glia and neurons. J. Neurosci. 16:1996;877-885.
41. Valnes K., Brandtzaeg P. Retardation of immunofluorescence fading during microscopy. J. Histochem. Cytochem. 33:1985;755-761.
42. Venance L., Cordier J., Monge M., Zalc B., Glowinski J., Giaume C. Homotypic and heterotypic coupling mediated by gap junctions during glial cell differentiation in vitro. Eur. J. Neurosci. 7:1995;451-461.
43. Vernadakis A. Glia-neuron intercommunications and synaptic plasticity. Prog. Neurobiol. 49:1996;185-214.
44. Werner R. E., Levine C., Rabadan-Diehl, Dahl G. Formation of hybrid channels. Proc. natn. Acad. Sci. U.S.A. 86:1989;5380-5384.
45. White T. W., Bruzzone R., Paul D. L. The connexin family of intercellular channel forming proteins. Kidney Int. 48:1995;1148-1157.
46. Wolburg H., Rohlmann A. Structure-function relationships in gap junctions. Int. Rev. Cytol. 157:1995;315-373.
47. Wolff J. R. (1987) The development of intracerebral blood vessels interacts with astrocyte development and neuron positioning in the rat neocortex. In Mesenchymal-Epithelial Interactions in Neural Development (eds Wolff J. R., Sievers J. and Berry M.), NATO ASI Series, Vol. H5, pp 399-412. Springer-Verlag, Berlin.
48. Yamamoto T., Ochalski A., Hertzberg E. L., Nagy J. I. Light microscope and electron microscope immunolocalization of the gap junction protein connexin43 in rat brain. Brain Res. 508:1990;313-319.
49. Yamamoto T., Ochalski A., Hertzberg E. L., Nagy J. I. On the organization of astrocytic gap junctions in rat brain as suggested by light microscope and electron microscope immunohistochemistry of connexin43 expression. J. comp. Neurol. 302:1990;853-883.
50. Yamamoto T., Vukelic J., Hertzberg E. L., Nagy J. I. Differential anatomical and cellular patterns of connexin43 expression during postnatal development of rat brain. Devl Brain Res. 66:1992;165-180.