Protective effects of a chalcone derivative against Aβ-induced oxidative stress and neuronal damage

BMB Reports

Volumn 44, Issue 11, 2011, Pages 730-734

  Kim, Mi Jeong ^a   Lee, Yoo Hyun ^b   Kwak, Jieun ^b   Na, Younghwa ^c   Yoon, Ho Geun ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Suwon University   (South Korea)

^c CHA University   (South Korea)

Author keywords

amyloid; Alzheimer's disease; Chalcone derivative; Cognitive function; Neuroprotective effect

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); CHALCONE; DRUG DERIVATIVE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; SCAVENGER;

ANIMAL; ARTICLE; BODY WEIGHT; CELL DEATH; CELL STRAIN; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MEMORY; MOUSE; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; BODY WEIGHT; CELL DEATH; CELL SURVIVAL; CHALCONE; FREE RADICAL SCAVENGERS; MALE; MEMORY; MICE; MICE, INBRED ICR; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; PEPTIDE FRAGMENTS; RATS;

GLYCYRRHIZA; MUS;

EID: 84863230324     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.11.730     Document Type: Article

References (24)

1. Yankner, B., Dawes, L., Fisher, S., Villa-Komaroff, L., Oster-Granite, M. L. and Neve, R. L. (1989) Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245, 417-420.
2. Zhu, X., Lee, H. G., Perry, G. and Smith, M. A. (2007) Alzheimer disease, the two-hit hypothesis: an update. Biochim. Biophys. Acta. 1772, 494-502.
3. Markesbery, W. R. (1997) Oxidative stress hypothesis in Alzheimer disease. Free Radic. Biol. Med. 23, 134-147.
4. Butterfield, D. A., Drake, J., Pocernich, C. and Castegna, A. (2001) Evidence of oxidative damage in Alzheimer's disease brain: central role of amyloid beta-peptide. Trens Mol. Med. 7, 548-554.
5. Butterfield, D. A. (2003) Amyloid beta-peptide [1-42]-associated free radical-induced oxidative stress and neurodegeneration in Alzheimer's disease brain: mechanisms and consequences. Curr. Med. Chem. 10, 2651-2659.
6. Butterfield, D. A., Galvan, V., Lange, M. B., Tang, H., Sowell, R. A., Spilman, P., Fombonne. J., Gorostiza, O., Zhang, J., Sultana, R. and Bredesen, D. E. (2010) In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP. Free Radic. Biol. Med. 48, 136-144.
7. Boyd-Kimball, D., Sultana, R., Mohmmad-Abdul, H. and Butterfield, D. A. (2004) Rodent Abeta(1-42) exhibits oxidative stress properties similar to those of human Abeta (1-42): Implications for proposed mechanisms of toxicity. J. Alzheimers Dis. 6, 515-525.
8. Dumont, M., Lin, M. T. and Beal, M. F. (2010) Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease. J. Alzheimers Dis. 20(Suppl 2), S633-643.
9. Dragicevic, N., Smith, A., Lin, X., Yuan, F., Copes, N., Delic, V., Tan, J., Cao, C., Shytle, R. D. and Bradshaw, P. C. (2011) Green Tea Epigallocatechin-3-Gallate (EGCG) and Other Flavonoids Reduce Alzheimer's Amyloid-Induced Mitochondrial Dysfunction. J. Alzheimers Dis. 1, 1-15.
10. Avdulov, N. A., Chochina, S. V., Igbavboa, U., O'Hare, E. O., Schroeder, F., Cleary, J. P. and Wood, W. G. (1997) Amyloid beta-peptides increase annular and bulk fluidity and induce lipid peroxidation in brain synaptic plasma membranes. J. Neurochem. 68, 2086-2091.
11. Butterfield, D. A. (1997) Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease. Chem. Res. Toxicol. 10, 495-506.
12. Castellani, R., Hirai, K., Aliev, G., Drew, K. L., Nunomura, A., Takeda, A., Cash, A. D., Obrenovich, M. E., Perry, G. and Smith, M. A. (2002) Role of mitochondrial dysfunction in Alzheimer's disease. J. Neurosci. Res. 70, 357-360.
13. Haraguchi, H., Ishikawa, H., Mizutani, K., Tamura, Y. and jinoshita, T. (1998) Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflate. Bioorg. Med. Chem. 6, 339-347.
14. Franceschelli, S., Pesce, M., Vinciguerra, I., Ferrone, A., Riccione, G., Antonia, P., Grilli, A., Felaco, M. and Speranza, L. (2011) Licocalchone-C extracted from Glycyrrhiza Glabra inhibits lipopolysaccharide-interferon-γ inflammation by improving antioxidant conditions and regulating inducible nitric oxide synthase expression. Molecules. 16, 5720-5734.
15. Haraguchi, H., Tanimoto, K., Tamura, Y., Mizutani, K. and Kinoshita, T. (1998) Mode of antibacterial action of retrochalcones from Glycyrrhiza inflate. Phytochemistry 48, 124-129.
16. Bak, E. J., Park, H. G., Lee, C. H., Lee, T. I., Woo, G. H., Na, Y. H. and Cha, J. H. (2011) Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4 and adipocyte differenciation in vitro. BMB Rep. 44, 410-414.
17. Im, S. E., Yoon, H., Nam, T. G., Heo, H. J., Lee, C. Y. and Kim, D. O. (2010) Antineurodegenerative effect of phenolic extracts and caffeic acid derivatives in romaine lettuce on neuron-like PC-12 cells. J. Med. Food 13, 779-784.
18. Heo, H. J. and Lee, C. Y. (2005) Strawberry and its anthocyanins reduce oxidative stress-induced apoptosis in PC12 cells. J. Agric. Food Chem. 53, 1984-1989.
19. Xue, H. Y., Gao, G. Z., Lin, Q. Y., Jin, L. J. and Xu, Y. P. (2011) protective effects of aucubin on H2O2-induced apoptosis in PC12 cells. Phytother. Res. doi:10.1002/ptr.3562. [Epub ahead of print]
20. Yan, J. J., Cho, J. Y., Kim, H. S., Kim, K. L., Jung, J. S., Huh, S. O., Suh, H. W., Kim, Y. H. and Song, D. K. (2001) Protection against β-amyloid peptide toxicity in vivo with long-term administration on ferulic acid. Br. J. Pharmacol. 133, 89-96.
21. Fu, A. L., Dong, Z. H. and Sun, M. R. (2006) Protective effect of N-acetyl-L-cysteine of amyloid ®-peptide-induced learning and memory deficits in mice. Brain Res. 1109, 201-206.
22. Tatton, W. G. (1993) Selegiline can mediate neuronal rescue rather than neuronal protection. Movement Disorders 8(Suppl 1), s20-s30.
23. Blois, M. S. (1958) Antioxidant determinations by the use of a stable free radical. Nature 181, 1199-1200.
24. Shen, Z., Wangn, G. and Linn, S. Z. (1990) Two-way shuttle box avoidance conditioning and brain NADH in rats. Physiol. Behav. 48, 515-517.