Identification of residues that underpin interactions within the eukaryotic Initiation Factor (eIF2) 2B complex

Journal of Biological Chemistry

Volumn 287, Issue 11, 2012, Pages 8263-8274

  Wang, Xuemin ^a,b   Wortham, Noel C ^a   Lius, Rui ^a,b   Prouds, Christopher G ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINARY COMPLEXES; CATALYTIC DOMAINS; EUKARYOTIC INITIATION FACTOR; NEUROLOGICAL DISORDERS; PROTEIN SYNTHESIS; SEQUENCE SIMILARITY; WHITE MATTER;

GENES; STOICHIOMETRY;

ENZYMES;

ACYLTRANSFERASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR EPSILON; GUANINE NUCLEOTIDE EXCHANGE FACTOR GAMMA; ISOLEUCINE; NUCLEOTIDYLTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; EUKARYOTE; GENE MUTATION; HUMAN; HUMAN CELL; NEUROLOGIC DISEASE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SUBUNIT; PROTEIN SYNTHESIS; SEQUENCE HOMOLOGY; VANISHING WHITE MATTER;

EUKARYOTIC INITIATION FACTOR-2B; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MULTIENZYME COMPLEXES; MUTATION; NERVOUS SYSTEM DISEASES; PEPTIDE MAPPING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EUKARYOTA;

EID: 84863229473     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.331553     Document Type: Article

References (40)

1. Pavitt, G. D. (2005) eIF2B, a mediator of general and gene-specific translational control. Biochem. Soc. Trans. 33, 1487-1492
2. Williams, D. D., Price, N. T., Loughlin, A. J., and Proud, C. G. (2001) Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. J. Biol. Chem. 276, 24697-24703
3. Wang, X., and Proud, C. G. (2008) A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B. Mol. Cell. Biol. 28, 1429-1442
4. Hardt, S. E., Tomita, H., Katus, H. A., and Sadoshima, J. (2004) Phosphorylation of eukaryotic translation initiation factor 2Bε by glycogen synthase kinase-3β regulates β-adrenergic cardiac myocyte hypertrophy. Circ. Res. 94, 926-935 (Pubitemid 38490070)
5. Gomez, E., and Pavitt, G. D. (2000) Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bε) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. Mol. Cell. Biol. 20, 3965-3976 (Pubitemid 30314495)
6. Gomez, E., Mohammad, S. S., and Pavitt, G. D. (2002) Characterization of the minimal catalytic domain within eIF2B. The guanine-nucleotide exchange factor for translation initiation. EMBO J. 21, 5292-5301
7. Asano, K., Krishnamoorthy, T., Phan, L., Pavitt, G. D., and Hinnebusch, A. G. (1999) Conserved bipartite motifs in yeast eIF5 and eIF2Bε, GT-Pase- activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2. EMBO J. 18, 1673-1688 (Pubitemid 29127079)
8. Koonin, E. V. (1995) Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs. Protein Sci. 4, 1608-1617
9. Steinbacher, S., Seckler, R., Miller, S., Steipe, B., Huber, R., and Reinemer, P. (1994) Crystal structure of P22 tailspike protein. Interdigitated subunits in a thermostable trimer. Science 265, 383-386 (Pubitemid 24259969)
10. Yang, Z., Zhou, Y., Liu, K., Cheng, Y., Liu, R., Chen, G., and Jia, Z. (2003) Computational study on the function of water within a β-helix antifreeze protein dimer and in the process of ice-protein binding. Biophys. J. 85, 2599-2605 (Pubitemid 37210805)
11. Bushman, J. L., Asuru, A. I., Matts, R. L., and Hinnebusch, A. G. (1993) Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol. Cell. Biol. 13, 1920-1932 (Pubitemid 23068132)
12. Paddon, C. J., Hannig, E. M., and Hinnebusch, A. G. (1989) Amino acid sequence similarity between GCN3 and GCD2, positive and negative translational regulators of GCN4. Evidence for antagonism by competition. Genetics 122, 551-559
13. Pavitt, G. D., Ramaiah, K. V., Kimball, S. R., and Hinnebusch, A. G. (1998) eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange. Genes Dev. 12, 514-526 (Pubitemid 28101014)
14. Pavitt, G. D., Yang, W., and Hinnebusch, A. G. (1997) Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2. Mol. Cell. Biol. 17, 1298-1313 (Pubitemid 27097359)
15. Craddock, B. L., and Proud, C. G. (1996) The α subunit of the mammalian guanine nucleotide exchange factor eIF-2B is essential for catalytic activity in vitro. Biochem. Biophys. Res. Commun. 220, 843-847 (Pubitemid 26198599)
16. Liu, A. R., van der Lei, H. D., Wang, X., Wortham, N. C., Tang, H., Van Berkel, C. G., Mufunde, T. A., Huang, W., Van der Knaap, M. S., Scheper, G. C., and Proud, C. G. (2011) Hum. Mutat. 32, 1036-1045
17. Fabian, J. R., Kimball, S. R., Heinzinger, N. K., and Jefferson, L. S. (1997) Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells. J. Biol. Chem. 272, 12359-12365 (Pubitemid 27203321)
18. Van der Knaap, M. S., Bugiani, M., Boor, I., Proud, C. G., and Scheper, G. C. (2010) The Online Metabolic and Molecular Bases of Inherited Diseases, Chap. 235.1, (Valle, D., Beaudet, A. L., Vogelstein, B., Kinzler, K. W., Antonarakis, S. E., Ballabio, A., Scriver, C. R., Sly, W. S., and Childs, B., eds) McGraw-Hill, New York
19. Pavitt, G. D., and Proud, C. G. (2009) Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease. Biochem. Soc. Trans. 37, 1298-1310
20. Fogli, A., Schiffmann, R., Hugendubler, L., Combes, P., Bertini, E., Rodriguez, D., Kimball, S. R., and Boespflug-Tanguy, O. (2004) Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients. Eur. J. Hum. Genet. 12, 561-566 (Pubitemid 39077164)
21. Horzinski, L., Huyghe, A., Cardoso, M. C., Gonthier, C., Ouchchane, L., Schiffmann, R., Blanc, P., Boespflug-Tanguy, O., and Fogli, A. (2009) Eukaryotic initiation factor 2B (eIF2B) GEF activity as a diagnostic tool for EIF2B-related disorders. PLoS. ONE 4, e8318
22. Rowlands, A. G., Panniers, R., and Henshaw, E. C. (1988) The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2. J. Biol. Chem. 263, 5526-5533
23. Wek, R. C., Jiang, H. Y., and Anthony, T. G. (2006) Coping with stress. eIF2 kinases and translational control. Biochem. Soc. Trans. 34, 7-11 (Pubitemid 43235522)
24. Hiyama, T. B., Ito, T., Imataka, H., and Yokoyama, S. (2009) Crystal structure of the α subunit of human translation initiation factor 2B. J. Mol. Biol. 392, 937-951
25. Li, W., Wang, X., Van Der Knaap, M. S., and Proud, C. G. (2004) Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. Mol. Cell. Biol. 24, 3295-3306 (Pubitemid 38452074)
26. Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., and Selbach, M. (2011) Global quantification of mammalian gene expression control. Nature 473, 337-342
27. Oldfield, S., and Proud, C. G. (1992) Purification, phosphorylation and control of the guanine-nucleotide-exchange factor from rabbit reticulocyte lysates. Eur. J. Biochem. 208, 73-81
28. Ohlenbusch, A., Henneke, M., Brockmann, K., Goerg, M., Hanefeld, F., Kohlschutter, A., and Gartner, J. (2005) Hum. Mutat. 25, 411
29. Yoder, M. D., Keen, N. T., and Jurnak, F. (1993) New domain motif. The structure of pectate lyase C, a secreted plant virulence factor. Science 260, 1503-1507 (Pubitemid 23273264)
30. Yoder, M. D., and Jurnak, F. (1995) Protein motifs. 3. The parallel β helix and other coiled folds. FASEB J. 9, 335-342
31. Pickersgill, R., Jenkins, J., Harris, G., Nasser, W., and Robert-Baudouy, J. (1994) The structure of Bacillus subtilis pectate lyase in complex with calcium. Nat. Struct. Biol. 1, 717-723
32. Raetz, C. R., and Roderick, S. L. (1995) A left-handed parallel β helix in the structure of UDP-N-acetylglucosamine acyltransferase. Science 270, 997-1000
33. Kisker, C., Schindelin, H., Alber, B. E., Ferry, J. G., and Rees, D. C. (1996) A left-hand β helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila. EMBO J. 15, 2323-2330 (Pubitemid 26151173)
34. Schulz, E. C., and Ficner, R. (2011) Knitting and snipping. Chaperones in β-helix folding. Curr. Opin. Struct. Biol. 21, 232-239
35. Fogli, A., Dionisi-Vici, C., Deodato, F., Bartuli, A., Boespflug-Tanguy, O., and Bertini, E. (2002) A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation. Neurology 59, 1966-1968 (Pubitemid 36076573)
36. Fogli, A., Schiffmann, R., Bertini, E., Ughetto, S., Combes, P., Eymard- Pierre, E., Kaneski, C. R., Pineda, M., Troncoso, M., Uziel, G., Surtees, R., Pugin, D., Chaunu, M. P., Rodriguez, D., and Boespflug-Tanguy, O. (2004) The effect of genotype on the natural history of eIF2B-related leukodystrophies. Neurology 62, 1509-1517 (Pubitemid 38608187)
37. Anthony, T. G., Fabian, J. R., Kimball, S. R., and Jefferson, L. S. (2000) Identification of domains within the ε subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. Biochim. Biophys. Acta 1492, 56-62 (Pubitemid 30349180)
38. Dholakia, J. N., Mueser, T. C., Woodley, C. L., Parkhurst, L. J., and Wahba, A. J. (1986) The association of NADPH with the guanine nucleotide exchange factor from rabbit reticulocytes.Arole of pyridine dinucleotides in eukaryotic polypeptide chain initiation. Proc. Natl. Acad. Sci. U.S.A. 83, 6746-6750 (Pubitemid 16002310)
39. Dholakia, J. N., Francis, B. R., Haley, B. E., and Wahba, A. J. (1989) Photoaffinity labeling of the rabbit reticulocyte guanine nucleotide exchange factor and eukaryotic initiation factor 2 with 8-azidopurine nucleotides. Identification of GTP- and ATP-binding domains. J. Biol. Chem. 264, 20638-20642 (Pubitemid 20009260)
40. Reid, P. J., Mohammad-Qureshi, S. S., and Pavitt, G. D. (2012) Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, nucleotide exchange factor for translation initiation. J. Biol. Chem. 287, 8275-8285