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Volumn 20, Issue 14, 2012, Pages 4489-4494

Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino- 4′-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase i inhibitors and cytotoxic agents

(11) Ye, Deyong a Shi, Qian a Leung, Chung Hang b Kim, Seung Whan b Park, Shin Young b Gullen, Elizabeth A b Jiang, Zao Li b Zhu, Hao c Morris Natschke, Susan L a Cheng, Yung Chi b Lee, Kuo Hsiung a,d

a UNC Hamner Institute for Drug Safety Sciences (United States)

b YALE UNIVERSITY SCHOOL OF MEDICINE (United States)

c USA (United States)

d CHINA MEDICAL UNIVERSITY (Taiwan)

Author keywords

Camptothecin (CPT); Conjugates; Cytotoxicity; Epipodophyllotoxin; Etoposide (VP 16); Topoisomerase

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN 4BETA ANILINO 4' O DEMETHYL EPIPODOPHYLLOTOXIN; CAMPTOTHECIN DERIVATIVE; CYTOTOXIC AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; GYRASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DNA CLEAVAGE; DNA STRAND BREAKAGE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DRUG RESISTANCE, NEOPLASM; HUMANS; PODOPHYLLOTOXIN; STEREOISOMERISM; TOPOISOMERASE I INHIBITORS;

EID: 84863212686 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.05.030 Document Type: Article

Times cited : (13)

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