Role of oxidative stress in reproductive toxicity induced by Co-administration of chloramphenicol and multivitamin-haematinics complex in rats

Basic and Clinical Pharmacology and Toxicology

Volumn 107, Issue 3, 2010, Pages 703-708

  Oyagbemi, Ademola A ^a   Adedara, Isaac A ^a   Saba, Adebowale B ^a   Farombi, Ebenezer O ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; ALKALINE PHOSPHATASE; AMINOTRANSFERASE; CATALASE; CHEMIRON; CHLORAMPHENICOL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LIPID; MULTIVITAMIN HEMATINIC COMPLEX; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VITAMIN B COMPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; LIPID PEROXIDATION; MALE; MONOTHERAPY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPRODUCTION; REPRODUCTIVE TOXICITY; SEMEN ABNORMALITY; SPERMATOZOON MOTILITY; WEIGHT REDUCTION;

5'-NUCLEOTIDASE; ANIMALS; ANTI-BACTERIAL AGENTS; BODY WEIGHT; CATALASE; CHLORAMPHENICOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG INTERACTIONS; GLUTATHIONE TRANSFERASE; HEMATINICS; LIPID PEROXIDATION; MALE; ORGAN SIZE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REPRODUCTION; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; SUPEROXIDE DISMUTASE; TESTIS; VITAMINS;

ANIMALIA; RATTUS;

EID: 77955794035     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2010.00561.x     Document Type: Article

References (41)

1. Van den Broek N. Anaemia and micronutrient deficiencies. Br Med Bull 2003 67 : 149 60.
2. Cook JD. Iron deficiency anaemia. Baillieres Clin Haematol 1994 7 : 787 804.
3. Popadic S, Popadic D, Ramic Z, Stojkovic MM, Trajkovic V, Milinkovic M et al. Chloramphenicol induces in vitro growth arrest and apoptosis of human keratinocytes. Cell Bio Toxicol 2006 22 : 371 9.
4. Farombi EO, Adaramoye OA, Emerole GO. Influence of chloramphenicol on rat hepatic microsomal components and biomarkers of oxidative stress: protective role of antioxidants. Pharmacol Toxicol 2002 91 : 129 34.
5. Holt DE, Harvey D, Hurley R. Chloramphenicol toxicity. Adv Drug React Toxicol Rev 1993 12 : 83 95.
6. Lautenbach E, Schuster MG, Bilker WB, Brennan PJ. The role of chloramphenicol in the treatment of bloodstream infection due to vancomycin-resistant Enterococcus. Clin Infect Dis 1998 27 : 1259 65.
7. Ricaurte JC, Boucher HW, Turett GS, Moellering RC, Labombardi VJ, Kislak JW. Chloramphenicol treatment for vancomycin-resistant Enterococcus faecium bacteremia. Clin Microbiol Infect 2001 7 : 17 21.
8. Pari L, Velmurugan K. Protective and antioxidant role of caffeic acid against chloramphenicol-induced hepatotoxicity in rats. In : Eddouks M (ed Advances in Phytotherapy Research.
9. Turton JA, Andrews CM, Havard AC, Williams TC. Studies on the haemotoxicity of chloramphenicol succinate in the Dunkin Hartley guinea pig. Int J Exp Pathol 2002 83 : 225 38.
10. Saba AB, Oyagbemi AA. The effect of multivitamin-haematinic complex on chloramphenicol-induced anaemia in rabbits. Int J Pharm 2007 3 : 411 5.
11. Holt DE, Ryder TA, Fairbairn A, Hurley R, Harvey D. The myelotoxicity of chloramphenicol: in vitro and in vivo studies: I. In vitro effects on cells in culture. Hum Exp Toxicol 1997 16 : 570 6.
12. Holt DE, Hurley R, Harvey D. Metabolism of chloramphenicol by glutathione S-transferase in human fetal and neonatal liver. Biol Neonate 1995 67 : 230 9.
13. Paez PL, Becerra MC, Albesa I. Chloramphenicol-induced oxidative stress in human neutrophils. Basic Clin Pharmacol Toxicol 2008 103 : 349 53.
14. Farombi EO, Nwankwo JO, Wara SH, Odutola B, Emerole GO. Chloramphenicol and ampicillin-induced changes in rat hepatic esterase and amidase activities. Biosci Rep 2000 20 : 13 9.
15. Cherry SM, Hunt PA, Hassold TJ. Cisplatin disrupts mammalian spermatogenesis, but does not recombination or chromosome segregation. Muta Res 2004 564 : 115 28.
16. Fukushima T, Kato M, Adachi T, Hamada Y, Horimoto M, Komiyama M et al. Effects of sulfasalazine on sperm acrosome reaction and gene expression in the male reproductive organs of rats. Toxicol Sci 2005 85 : 675 82.
17. Murat Y, Orhan B, Hakan M, Onder S, Ahmet N, Ozcan K et al. Protective effects of erdosteine on doxorubicin-induced hepatotoxicity in rats. Arch Med Res 2007 38 : 380 5.
18. Farombi EO, Ugwuezunmba MC, Ezenwadu TT, Oyeyemi MO, Ekor M. Tetracycline-induced reproductive toxicity in male rats: effects of vitamin C and N-acetylcysteine. Exp Toxicol Pathol 2008 60 : 77 85.
19. Oyeyemi MO, Adeniji DA. Morphological characteristics and haematological studies in wistar rats subjected to prolonged treatment of chloramphenicol. Int J Morphol 2009 27 : 7 11.
20. Clairborne A. Catalase activity. In : Greewald AR (ed Handbook of Methods for Oxygen Radical Research. CRC Press
21. Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972 247 : 3170 5.
22. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974 249 : 7130 9.
23. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951 193 : 265.
24. Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4 bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974 11 : 151 69.
25. Wolff SP. Ferrous ion oxidation in the presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol 1994 233 : 182 9.
26. Farombi EO, Tahnteng JG, Agboola AO, Nwankwo JO, Emerole GO. Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron - a Garcinia kola seed extract. Food Chem Toxicol 2000 38 : 535 41.
27. Goodland GAJ, Catherine MC. Alteration in hepatic 5′ nucleotidase in the tumor bearing rat. Enzyme 1982 27 : 11 123.
28. Reitmann S, Frankel S. Colorirnetric method for the determination of serum transaminase activity. Am J Clin Path 1957 28 : 56 68.
29. Rec. Gscc (DGKC). Optimised standard colorimetric methods. J Clin Chem Clin Biochem 1972 10 : 182.
30. Zemjanis R. Collection and evaluation of semen. In : Zemjanis R (ed Diagnostic and Therapeutic Technique in Animal Reproduction, 2nd edn. The William and Wilkins Company, Waverly Press Inc.
31. Pant N, Srivastava SP. Testicular and spermatotoxic effects of quinalphos in rats. J Appl Toxicol 2003 23 : 271 4.
32. Wells ME, Awa OA. New technique for assessing acrosomal characteristics of spermatozoa. J Dairy Sci 1970 53 : 227.
33. Tremellen K. Oxidative stress and male infertility - a clinical perspective. Hum Reprod Update 2008 14 : 243 58.
34. Dimitrova MST, Tsinova V, Velcheva V. Combined effect of zinc and lead on the hepatic superoxide dismutase-catalase system in carp (Cyprinus carpio). Comp Biochem Physiol 1994 108 : 43 6.
35. Albesa I, Becerra MC, Battan PC, Paez PL. Oxidative stress involved in the antibacterial action of different antibiotics. Biochem Biophys Res Commun 2004 317 : 605 9.
36. Farombi EO. Antioxidant status and hepatic lipid peroxidation in chloramphenicol-treated rats. Tohoku J Exp Med 2001 194 : 91 8.
37. Saradha B, Mathur PP. Induction of oxidative stress by lindane in epididymis of adult male rats. Environ Toxicol Pharmacol 2006 22 : 90 6.
38. Newby AC, Luzio JP, Hales CN. The properties and extracellular location of 5′-nucleotidase of the rat fat-cell plasma membrane. Biochem J 1975 146 : 625 33.
39. Ikegwuonu FI, Egbunike GN, Emerole GO, Aire TA. The effects of Aflatoxin B1 on some testicular and kidney enzyme activity in rat. Toxicology 1980 17 : 9 16.
40. Sikka SC, Rajasekaran M, Hellstrom WJ. Role of oxidative stress and oxidants in male infertility. J Androl 1995 16 : 464 8.
41. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003 102 : 783 8.